Renal Physiology Flashcards
What is absorbed in the PCT?
Most ions and glucose
What is absorbed in the ascending loop of Henle and what is the key transporter of these?
Ion transport via NKCC
What is absorbed in the descending loop of Henle?
Water
What is absorbed in the DCT and what are the two types of cells?
Ions final Na+, H+ and K+ concentration determination
Intercalated cell and principal cell
What is absorbed in exchange for what in the principle cell?
Na+ in
K+ out
What is absorbed in exchange for what in the intercalated cell?
H+ out
K+ in
What is the main channel that aldosterone acts on and where is this found?
ENAC
Principle cell
What maintains GFR rate in times of low renal blood flow?
Afferent dilation by Prostaglandins
Efferent constriction by Angiotensin
What is produced in a hydrated state to maintain the same GFR?
Adenosine
What is released in response to low Na+ or low renal blood flow to increase overall blood pressure?
Renin from the glomerular apparatus
How does renin work to increase blood pressure?
Catalyses the conversion of angiotensinogen to angiotensin I
ACE converts angiotensin I to II
What is the role of angiotensin II in increasing blood pressure?
Potent vasoconstrictor
Increases ADH release
Increase aldosterone release
Efferent arteriole constriction.
What is the role of the collecting duct and what hormone is key in controlling the function?
ADH or Vassoprisin released from the posterior pituitary.
Key for water reabsorption
