Renal Physiology Flashcards
State the components of a filtration
Capillary endothelium
Glomerular basement membrane
Podocyte foot process
What’s the other name of juxtaglomelular cells
Granular cells
What is the other name of the extra mesangeal cells
The lacis or Polkisens cells
Hey name the two types of cells found on the collecting ducts
The principal cells and the intercalated cells
State the two types of collection ducts
The cortical and medullary collecting duct
Which hormones act on the collecting ducts
Aldosterone and adh(vasopressin hormone)
Aldosterone
@It is a mineral corticoid produced from the zona gromerulosa of adrenal gland
@it is involved in sodium metabolism
@It’s acts on both principle and intercalated cells
What’s the major stimulus of aldosterone secretion
Hyperkalaemia
When Aldosterone acts on principle cells of the dct it increase sodium abosorption which eventually cause increased water reabsoption
But increases potassium excretion
When aldosterone acts on the inter
All stereoid hormone can easily cross the cell membrane and there receptor are inside cell (intracellar receptors
What substances cause the following
Mesarngeal cells contraction
Mesarngeal cells relaxation
Afferent arterial contraction
Afferent arterial relaxation
1:angiotensin 2 and endothelin
2;atrial natrialtic peptides and nitric oxide
3:norepinephrine and adenosine
4;prostaglandins
Nitric oxide uses ——-as a secondary messenger
Cgmp
The condition were the pct is not functional is——?
Fanconi syndrome
Which segment of the nephrons contributes most to potassium excretion when dietary potassium is altered
The distal segment and the collecting duct
