Renal Path Flashcards by Brendan LeBaron

Q

Deposits of neutrophils, IgG and complement

A

Post Infectious Proliferative GN

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Q

IF - Lumpy irregular pattern

A

Post Infectious Proliferative GN

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Q

Anti-GBM Ab mediated

A

Goodpasture

Type 1 RPGN

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Q

Antigen is NC1 domain of alpha 3 chain, type 4 collagen

A

Goodpasture

Type 1 RPGN

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Q

IF - linear IgG pattern

A

Goodpasture

Type 1 RPGN

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Q

Granular Ig and C3

Differentiated by IF

A

Immune complex: SLE or IgA

Type 2 RPGN

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Q

Crescentic proliferation and vasculitis, ANCA positive

A

Pauci Immune

Type 3 RPGN

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Q

Pulmonary hemorrhages

A

Goodpasture

Type 1 RPGN

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Q

ANA and ANCA negative, Low C3

A

Post Infectious Proliferative GN

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Q

Deposits of cartilage, blue hyaline

A

Multicystic Renal Dysplasia

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Q

Unilateral deformed kidney in younger patient

A

Multicystic Renal Dysplasia

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Q

Mutation coding for PKD1 - polycystin

A

Autosomal Dominant Polycystic Kidney Disease

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Q

Palpable masses in kidneys, bilateral

A

Autosomal Dominant Polycystic Kidney Disease

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Q

Associated with berry aneurysms

A

Autosomal Dominant Polycystic Kidney Disease

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Q

Patients die in infancy

A

Autosomal Recessive Polycystic Kidney Disease

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Q

Mutations coding for PKHD1 - fibrocystin

A

Autosomal Recessive Polycystic Kidney Disease

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Q

Numerous small cysts, sponge appearance

A

Autosomal Recessive Polycystic Kidney Disease

Q

Associated with congenital hepatic fibrosis

A

Autosomal Recessive Polycystic Kidney Disease

Q

Mutations coding for NHP1-9 Nephrocystin

A

Nephronophthisis - Medullary disease

Q

Small contracted kidneys, cysts at the corticomedullary junction

A

Nephronophthisis - Medullary disease

Q

Tubulointerstitial damaged, glomerulus spared

A

Nephronophthisis - Medullary disease

Q

Associated with retinitis pigmentosa

A

Nephronophthisis - Medullary disease

Q

Effacement of podocytes

A

MCD or FSGS

Q

Children puffy face

A

MCD

Responds to steroids

MCD

Selective proteinuria

MCD

Foamy cells

MCD

Segmental scarring

FSGS

IF shows IgM and C3 in sclerotic areas

FSGS

Non selective proteinuria

FSGS

Not responsive to steroids

FSGS

HIV infection

Collapsing FSGS

KW nodule and arteriolar hyaline

Diabetic Glomerulosclerosis

Complement forms MAC

M GN

Immune against PLA2R - phospholipase A2 receptor

M GN

IgM, granular deposits in sub epithelial space

M GN

At risk for developing thrombosis

M GN

Subendothelial immune deposits

MP GN

Duplication of GBM

MP GN

Lobular pattern of proliferation

MP GN

Subendothelial C3 deposits

C3 GN / MPGN Type 2

Dense deposit disease

C3 GN / MPGN Type 2