Renal + GU Flashcards
Name 3 processes that contribute to urine storage
Receptive relaxation
- Detrusor stretching
- no tension
- no increase pressure
Symapthetic stimulation
T11 - L2
Detrusor relaxation
Pudendal nerve stimulation
S2 - S4
E.U.S contraction
factors affecting eGFR
Extreme muscle mass is misleading
- bodybuilder
- amputee
Kidney functions
- Elimination of wate material
- Regulation of volume + body fluid composition
- Endocrine
EPO, Renin, Active Vit D - Reabsorption
Glucose, a.a, bicarbonates
how is urine transported in the ureter
Peristalsis
How is reflux of urine prevented at the bladder
Valvular mechanism
- At the Vesicoureteric
junction
What is the only protein in the urine
Tom Horsfall - Secreted by thick loop
Nerve that controls urine storage
Hypogastric plexus
T11 - L2
Noradrenaline NT
Nerve that controls voiding urine
Pelvic nerve
S2 - S4
Ach NT
Voluntary control of urine
Pudendal nerve
S2 - S4
Ach NT –> E.U.S
What controls the guarding reflux
Onuf’s nucelus
What is located in the PAG
Pontine mictruition centre
Function of the pontine mictruition centre
- Inhibitory signals to the detrusor muscle
- Excitatory signals to Onuf’s nucleus
- Signals from T11-L2 (Hypogastric nerve) via sympathetic nerves
- Bladder relaxes
- Contraction of internal urethral sphincter
Voiding phase pathophsiology
- Pontine mictruition centre sends excitatory signals to detrusor
- Inhibits Onufs nucleus
- Signals from S2-S4 (Pudendal nerve) via PNS
How much urine can the bladder store and when is the firsr sensation of bladder storage felt
500ml
100-200ml - first sensation
Name the 3 common sites for kidney stones to lodge
- Pelviureteric junction
- Pelvic brim
- Vesicoureteric junction
What are most kidney stones made from
- Calcium oxalate
- Calcium phosphate
- Mg ammonium phospahte
(Struvite) - Uric acid
- Cystine
Name 2 factors contributing to urine supersaturation
- decreased urine volume
- Increase/decrease urine
pH
Name 2 factors decreasing the action of stone forming inhibitors
Mg
Citrate
Name 4 foods that increase oxalate diet intake
Spinach
Chocolate
Tea
Rhubarb
Name 1 complication of a stone causing obstruction within the urinary tract
Hydronephrosis
- Proximal dilatation of ureter and renal pelvis due to obstruction
- can cause lasting kidney damage
What causes hypercalciuria leading to calcium stones
Hyperparathyroidism
Excessive Ca2+ intake
Primary renal disease - PCKD
Stone composition: Struvite stones - metals - assosc - what favours this stone formation
Ammonium
Mg
Ca2+
Chrnoic UTIs
- Klebsiella
- Pseudomonas
Alkaline urine pH
Increase ammonium conc
Stone composition:
Uric acid
- Assosc
- which patients are high risk
Hyperuricaemia
Clinical gout
Dehydration
Pts with ileostomies
Renal colic presentation
- Sx
Pain - Acute flank (Stabbing) - Radiation: Loin/Groin/Genitals Nausea Vomitting Sweating
Triad:
Fever
Acute flank pain
Vomitting
Bladder stones signs
- Urinary frequency
- Haematuria
Urethral stones signs
Bladder outflow obstruction
- Anuria
- Painful bladder distension
Renal colic signs
- Can’t lie still
- Nausea
- Haematuria
- Dysuria
- Strangury
severe pain
strong desire to urinate
Renal colic differential diagnosis
Ectopic pregnancy
Appendicitis
Diverticulitis
Testicular torsion
Renal colic investigations
Urine dipstick
- Haematuria
Midstream urine
- Culture + sensitivity
1st line:
- KUB X-ray
GOLD/ Diagnostic:
- non contrast KUB CT
- No contrast so no renal
damage
Indications for renal colic intervention
- Persistent pain
- Infection
- Failure of stone to pass
Renal colic management
NSAIDs
- Diclofenac (75mg)
Fluids
Abx if infection
- Gentamicin
- Cefuroxine
What size must a stone be to require medical intervention
Stone < 5mm - spontaneous resolution
Stone > 5mm or pain not resolving
- medical expulsive therapy
What can be used to help aid spontaneous passage of stones
Tamsulosin
- Alpha blocker
- promotes expulsion
What is AKI
clinical syndrome of decreased renal function occuring over hours/days
- Usually reversible
Critera for AKI diagnosis
Rise in creatnine:
>26micrmol/L in 48hrs
Rise in creatnine >1.5x baseline within 7 days
Urine output < o.5ml/kg/h for 6hrs
name and describe the classification used in AKI
RIFLE
R - Risk I - Injury F - Failure L - Loss E - End stage kidney disease
Limitations of using creatnine as a biomarker
Muscle mass
Dilution
AKI risk factors
Pre-existing CKD Age Male Co-morbidities - DM - CVD - Cancer
How can AKI be classified
Pre renal
Intra renal
Post renal
Pre renal AKI causes
Hypovolemia
- Trauma
- Burns
Decrease CO - MI
Systemic vasodilation
- Sepsis
- Anaphalaxis
Afferent A vasoconstriction
- NSAIDs
Efferent A vasodilation
- ACEi/ARB
Inra renal causes of AKI
Glomerulonephritis
- SLE
- Infection
Acute interstitial nephritis
- Drugs
- Infection
Acute tubular necrosis
- Secondary to ischaemia due to hypovolemia
Vasculitis
- SLE
Post renal AKI causes
Obstructive uropathy
- Kidney stones
- Strictures (Ureter/Urethral)
- Renal tract malignancy
- BPH
- Prostatic cancer
How can you differentiate between pre or intra renal AKI causes from urine tests
Intra renal has HIGH Na+ urine compared to pre-renal
Causes of Acute tubular necrosis
- Gentamicin
- NSAIDs
- ACEi
- Acute pancreatitis
- MI / CCF
- Diuretics
- Haemorrhage
AKI presentation
- Anuria
Uraemia sx:
- Fatigue
- Seizures
- Weakness
- nausea
- confusion
- vomitting
Dehydration –> Poor tissue tirgor
AKI emergencies and consequent complications
Hyperkalaemia
- Arrhythmias
Fluid overload
- Heart failure
- Pulmonary oedema
Metabolic acidosis
Uraemia
- Encephalopathy
- Pericarditis
No urine produced
AKI differential diagnosis
- AAA
- DKA
- CKD
- Heart failure
- Metabolic acidosis
AKI investigations
Urinalysis: Dipstick --> Infection Haematuria Proteinuria Glomerulonephritis
Imaging:
- US –> obstruction
- CT-KUB –> Retroperitonea;
fibrosis
Pre renal AKI tx
- Fluids
- Abx if sepsis
Post renal AKI tx
Catheter
Nephrostomy
AKI general tx
Stop nephrotoxic drugs
- NSAIDs
- ACEi
Fluid balance
- monitor intake
- monitor urine output
Indications for dialysis after AKI
- Pulmonary oedema
- Severe metabolic acidosis
pH < 7.1 - Removal of causative nephrotoxic drugs
What is CKD
Long standing reduction in kidney function
- Permanent
- Progressive
What GFR is assosciated with CKD
GFR < 60ml/min/1.73m2
With or without Albuminuria
CKD causes
- Diabetes
- HTN
- Glomerulonephritis
- Age related decline
- Congenital –> PCKD
- Amyloidosis
- SLE
Tubulointerstitial disease
1 –> UTI / Stones
2 –> Drugs / toxins
what is the typical decline in GFR as we age
2ml/ min/ year
CKD presentation
Early: Malaise Loss of appetite Uraemic: Yellow Itchy Anaemia Fluid overload: Oedema - Pulmonary - Peripheral Kidneys apprear SMALL
Late:
Myoclonus
Oligouria
Where do renal cell carcinomas arise from
Proximal convuluted tubulal epithelium
RCC risk factors
- Smoking
- Obesity
- Von - hippel lindau syndrome
- Petroleum
- Asbestos
- Leather tanners
Renal cell carcinoma presentation
- Haematuria
- Loin/Flank pain
- Mass
- Fever
- Weight loss
- Malaise