RENAL & GENITOURINARY Flashcards
I cause the following in children:
Infants: Poor feeding, vomiting, irritability
Younger children: Abdominal pain, fever, dysuria
Older children: Dysuria, frequency, haematuria
Temp over 38 and loin/abdominal pain
WHAT AM I?
URINARY TRACT INFECTION
How do you identify me? (UTI)
- Mid stream urine sample to avoid contamination
- Urinanalysis
How do you manage me? (UTI)
- Infants 3 monts: Immediate referral to paediatrician
- 3 - 11 months: Hospital admission or antibiotic treatment Cefalexin (125mg x2 daily 7-10 days). (If culture results are available)
- 1–4 years: 125mg x3 daily 7-10 days
- 5 –11 years: 250mg x3 daily 7-10 days
- 12–15 years: 500 mg 2-3x daily 7-10 days
Co-Amoxiclav
- 3 –11 months: 0.25 mL/kg of 125/31 suspension 3x daily 7-10 days
- 1–5 years: 125/ 31 suspension three times a day for 7–10 days
- 6 –11 years: 5 ml of 250/ 62 suspension three times a day for 7–10 days
- 12–15 years: 500/125 mg three times a day for 7–10 days.
How do you manage recurrent UTIs in children?
1. Antibiotic prophylaxis: Trimethoprim: - 3–5 months: 12.5 mg at night - 6 months to 5 years: 25 mg at night. - 6–11 years: 50 mg at night. - 12–15 years — 100 mg at night.
Second line:
Cefalexin:
- 3 months to 15 years: 12.5 mg/kg at night
Amoxicillin for ages:
- 3 months to 11 years — 62.5 mg at night.
- 1–4 years — 125 mg at night.
- 5–15 years — 250 mg at night.
I cause the following:
- Newborns: no fever but poor feeding and vomiting
- Children <2: may have a fever (but not always), a poor appetite, vomiting and diarrhoea.
- Children >2: fever, appetite changes, stomach or lower back pain, symptoms of urgency, frequency and pain with urination.
WHAT AM I?
PYELONEPHRITIS
How am I managed? (Pyelonephritis)
- Management same as UTI oral Antibiotics
How am I managed? (Pyelonephritis)
- Management same as UTI oral Antibiotics
I cause the following:
- Sudden pain
- Unilateral flank pain
- Abdominal flank pain radiating to the labia in women and testicular pain
- Nausea, vomiting, haematuria
- Fever, Shivers, sweats
WHAT AM I?
ACUTE RENAL COLIC
How do you identify me? (Renal Colic)
- Children:
First line: Ultrasound
Second line: Low dose CT if uncertain about diagnosis - Blood testing:
- ## Serum Calcium: To identify treatable conditions like uric acid stones, and primary hyperparathyroidism.
How do you manage me? (Renal Colic)
- Stone less than 5mm - watch and wait for it to pass
- Stone greater than 5mm: medical expulsive therapy: Alpha Blockers
- Surgical treatment if stone is not likely to pass.
Shockwave lithotripsy (SWL) - shock waves to break up the stones
Percutaneous nephrolithotomy (PCNL) - nephroscope is passed percutaneously into the collecting system and the stone is fragmented and extracted
Ureteroscopy (URS) — involves the use of various energy sources (such as lasers) to break up the stone.
Open surgery if stone is too large or all other methods fail
I cause the following:
- I usually affect children ages 2-5 years of age
- Leak large amounts of protein in the urine > 1 g/m^2 per 24 hours
- Hypoalbuminaemia (< 25 g/l) - protein responsible for keeping fluids in the blood vessels
- I cause body tissue to swell
- Cause Hyperlipidaemia, a hypercoagulable state (due to loss of antithrombin III) and a predisposition to infection (due to loss of immunoglobulins)
WHAT AM I?
NEPHROTIC SYNDROME
How do you identify me? (Nephrotic syndrome)
- Urine dip stick shows albuminuria
- FBC, coagulation screen, Glucose, Autoimmune screen
How do you manage me? (Nephrotic syndrome)
- Depends on the cause. Refer to nephrologists early for further investigations.
- Fluid and salt restriction.
- Treatment of complications e.g lipid control by giving statins (Artorvastatin)
- Children diagnosed with nephrotic syndrome for the first time are normally prescribed at least a 4-week course of the steroid medicine prednisolone
- Diuretic e.g furosemide to help with fluid overload
- Sometimes angiotensin-converting enzyme (ACE) inhibitors for high blood pressure.
I cause the following:
- Peripheral oedema
- Macroscopic Haematuria coca cola colour
- Reduced urine output
- Hypertension
- Anorexia, pruritus, lethargy, nausea
WHAT AM I?
ACUTE NEPHRITIS
How do you manage me? (Acute Nephritis)
- Refer to secondary care
- Investigations are focused on assessing severity of renal injury and looking for the underlying cause
- Management depends on the underlying cause of acute nephritis.