Renal Disorders Flashcards
Streptococci form immune complexes with their corresponding circulating antibodies and become deposited on the glomerular membranes. The accompanying inflammatory reaction affects glomerular function.
Acute or Poststreptococcal Glomerulonephritis
A more serious form of acute glomerular disease is called rapidly progressive (crescentic) glomerulonephritis and has a much poorer prognosis, often terminating in renal failure.
Rapidly Progressive Glomerulonephri
A cytotoxic autoantibody can appear against the glomerular and alveolar basement membranes after viral respiratory infections.
Goodpasture’s Syndrome
Attachment of this autoantibody to the basement membrane, followed by
complement activation, produces the capillary destruction.
Goodpasture’s Syndrome
Causes a granuloma-producing inflammation of the small blood vessels
primarily of the kidney and respiratory system
Wegener’s Granulomatosis
Initial symptoms include the appearance of raised, red patches on the skin
Henoch-Schönlein Purpura
Deposition of IgA on the glomerular membrane resulting from increased levels of serum IgA
IgA Nephropathy / Berger disease
IgA Nephropathy is also known as _________
Berger disease
Thickening of the glomerular basement membrane resulting from the deposition of immunoglobulin G immune complexes associated with systemic disorders
Membranous Glomerulonephritis
Marked decrease in renal function resulting from glomerular damage precipitated by other renal disorders
Chronic Glomerulonephritis
Disruption of the electrical charges that produce the tightly fitting podocyte barrier resulting in massive loss of protein and lipids
Nephrotic Syndrome
Minimal Change Disease is also known as _________
lipid nephrosis
Disruption of the podocytes following allergic reactions, recent immunizations and possession of the human leukocyte antigen-B12 antigen have been associated with this disease
Minimal Change Disease / Lipid Nephrosis
Disruption of podocytes associated with heroin/analgesic abuse and AIDS
Focal Segmental Glomerulosclerosis
Damage to RTE cells caused may be produced by decreased blood flow
that causes a lack of oxygen presentation to the tubules (ischemia) or the presence of toxic substances in the urinary filtrate.
Acute Tubular Necrosis
The syndrome consists of a generalized failure of tubular reabsorption in the proximal convoluted tubule
Fanconi’s Syndrome
Cystitis
Ascending bacterial infection of the bladder
Inherited in association with cystinosis and Hartnup disease or acquired (exposure to toxic agents)
Fanconi’s Syndrome
Frequently occurs as a result of ascending movement of bacteria from a lower UTI into the renal tubules and interstitium.
Acute Pyelonephritis
Infection of the renal tubules and interstitium related to interference of urine flow or reflux of urine from the bladder, and untreated cystitis
Acute Pyelonephritis
Recurrent infection of the renal tubules and interstitium caused by structural abnormalities affecting the flow of urine
Chronic Pyelonephritis
Allergic inflammation of the renal interstitium of the renal interstitium
followed by inflammation of the renal tubules
Acute Interstitial Nephritis
Is primarily associated with an allergic reaction to medications that occurs
within the renal interstitium, possibly caused by the medication binding to
the interstitial protein
Acute Interstitial Nephritis
May be gradual progression from the original disorder to chronic renal failure or end-stage renal disease
Renal Failure
