Renal Control Flashcards

1
Q

what is pH a measure of?

A

it is a measure of the acidity or alkalinity of a solution

pH= -log10[H+]

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2
Q

what is a buffer?

A

a compound that resists changes in pH

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3
Q

what range of pH does the blood stay in ?

A

7.35-7.45

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4
Q

what organ maintains the blood pH?

A

lungs and kidneys

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5
Q

why is it necessary to maintain plasma pH constant?

A

to maintain the pH of cell fluid at approximately ph 7.0 which is necessary for cellular reactions to occur

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6
Q

metabolism of carbohydrates and fats produces what?

A

produces CO2 and H2O (CO2 is acidic and is eliminated by the lungs)

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7
Q

amino acid metabolism produces what?

A

Cystein and Methionine (sulfur containint) produce sulfuric acid

Lys, Arg, and His AA prduce HCl

partially offset by Asp, Glut, which produces alkiline produce

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8
Q

metabolism of organic anions produces what?

A

eX) citrate - produces Alkali (HCO3-)

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9
Q

What factors effect blood pH?

A

metabolism of carbohydrates, fats, amino acids, organic anions, and dietary components

*in general net acid production exceeds alkali*

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10
Q

which buffer system (unlike Phosphate buffer) is regulated by both the lungs and the kindey?

A

HCO3- (bicarbonate) buffer system

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11
Q

what equation quantifies how changes in CO2 and HCO3- affect pH?

A

Henderson - Hasselbach Equation

the pH of the system depends on the ratio of molar conc. bicarbonate to pressure carbon dioxide

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12
Q

[HCO3] is maintained at what constant molar volume by the kidneys?

A

24mmol/:L

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13
Q

paCO2 is maintained at what constant pressure by the lungs?

A

40mmHg

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14
Q

is there a tendency for plasma [HCO3] or paCO2 to change and consequently alter the pH?

A

Yes.

there is a tendency for pCO2 to rise and for [HCO3] to fall - either would result in a decreased pH

normally the pH does not decrease because the lungs and kidneys counteract these changes and prevent the change in pH

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15
Q

where is CO2 produced?

A

it is continuously produced by cellular metabolism in all tissues - the pressure of CO2 does not rise in the blood and lower the pH because the lungs eliminate CO2 as rapidly as it is produced

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16
Q

how does the bicarbonate concentration of the blood fall? [HCO3]

A

it is a buffer for dietary components of acid or end products of metabolism - these acids are buffered by bicarbonate thus lowering the concentration of bicarb

17
Q

how does the kidney prevent a decrease in plasma [HCO3] and a fall in pH?

A
  1. tubular cells reabsorb all the [HCO3] from the tubular filtrate - maintains the plasma [HCO3-] at its existing level
  2. the tubular cells synthesise an amount of bicarb equivalent to that consumed in buffering and add it to the blood - this will restore plama [HCO3] to normal
18
Q

describe how HCO3 is reabsorbed by intercalated cells of collecting duct

A
19
Q

describe how HCO3 is secreted by beta intercalated cells of collecting duct

A
20
Q

how is generation of new HCO3- achieved?

A
  1. by the excretion of H+ with non HCO3- urinary buffers
  2. by the synthesis and excretion of NH4+ (non-ionic diffusion and diffusion trapping) - most of the NH4+ formed in the PT is reabsorbed in the TAL with NH4+ substituting for K+ on the Na/K/2Cl symporter