Renal Considerations of Fluids and Electrolytes Flashcards
What is Hypokalemia
a serum potassium concentration of less than 3.5 mEq/L
At what point is hypokalemia considered severe
a mEq/L of less than 2.5
What typically causes deficits in potassium
poor dietary intake
excessive loss of body fluid (typically these losses are from the GI or renal systems)
Often renal loss or potassium occurs from
diuretic treatment
or renal tubular / interstitial disease hyperaldosteronism
Clinical features of Hypokalemia
mild- can be asymptomatic
Cardiovascular manifestations are the most important- hypotension, palpation and or ventricular arrhythmias, Cardiac arrest
Neuromuscular manifestations include: Generalized malaise, Skeletal muscle weakness / cramps, Smooth muscle problems with constipation and ileus
Muscle cell breakdown known as ___________ is possible with decreased intracellular potassium levels
Rhabdomyolysis
when critically low potassium (severe less than 2.5) you might see
Flaccid paralysis
Hypercapnia
severe rhabdomyolysis
Diagnostic Findings of Hypokalemia
Serum potassium levels less than 3.5
EKG findings- flattened or inverted T waves, Prominent U waves, ST depression, Premature Ventricular Contractions.
Urine potassium less than 20 mEq/L suggests GI losses, while greater than 40 suggests Diuretic use
How to treat emergency situation of hypokalemia
IV potassium chloride
How to manage non-emergent situations of hypokalemia
oral Potassium therapy usually Potassium Chloride
Important factor in treating hypokalemia
Ensuring to treat the underlying cause of the hypokalemia
What level of total body potassium constitutes Hyperkalemia
greater than 5.0 mEq/L
Hyperkalemia is most commonly associated with
- Renal Failure
- ACEi therapy (38% of hospital admissions)
- Potassium-sparing diuretic use (spironolactone)
- Hyporenimeic hypoaldosteronism
- Cellular death
- Metabolic Acidosis
Clinical Features of Hyperkalemia
mild can be asymptomatic
- Severe- arrhythmias and death
- S/S are that are relatively common:
Numbness / tingling in extremities, muscle weakness, flaccid paralysis, Depressed or absent Deep Tendon Reflexes, Palpations
Diagnostic findings of Hyperkalemia
serum pot. > 5.0 mEq/L
- if secondary to renal dysfunction; BUN and Creatinine will be elevated
- ABG’s may reveal metabolic acidosis
EKG findings of Hyperkalemia
include: Peaked T waves , Prolonged PR segment, Loss of P wave, Prolonged ORS complex, ST-segment elevation, Ectopic beats and escape rhythms, Progressive widening of QRS complex, Sine wave, Ventricular fibrillation, Asystole, Axis deviations, Bundle branch blocks, Fascicular blocks
Management of Hyperkalemia
aggressiveness depends on pot. level and evidence of cardiac toxicity
Life-threatening hyperkalemia should be treated immediately and look for cause.
Severe- Give IV Calcium Gluconate to stabilize cardiac membranes
Administer nebulized Albuterol (beta agonist)
Management of Hyperkalemia
if severe… also add IV sodium Bicarbonate to lower potassium level. This draws Hydroen out of the cells
IV Glucose (dextrose 50 ) with IV insulin are also utilized
Other treatment options for hyperkalemia
Diuretics that are not potassium sparing
Kayexalate - acts on GI to excrete Potassium
Dialysis - tx option if no other treatment works or if there are other contraindications to other treatments
True or False- Sodium concentration is not actually demonstrating sodium serum levels
True- it is important to understand that it is actually reflecting disturbance in water homeostasis
Think of it as ore a representation of the total body amount of sodium
Medical term for low sodium levels
Hyponatremia
What sodium serum conc. defines hyponatremia
less than 135 mEq/L
S/S might not occur in hyponatremia until what mEq/L level
125