Renal Cancer Drugs

Question 1

Common sites for Metastatic growth of renal cancer?

Answer 1

LLBOS,….. Lymph Nodes, LungLiverBone, Brain, Other kidney, subcutaneous skin nodules

Question 2

What is the standard therapy for Wilms Tumor

Answer 2

Vincristine, dactinomycin (18 weeks)
Vincristine, Dactinomycin, Doxorubicin (24 weeks)
Vincristine Doxorubcin, Cyclophosphamide, Etoposide
SO,,,,VD, VDD, VDCE

Question 3

Clear Cell carcinomoa treatement?

Answer 3

VDD or VDCE treatement. All with radiation therapy

Question 4

Carboplatin used with what and for what>

Answer 4

Can be used with cyclophosphamide to treat recurrent disease.

Question 5

Carboplatin toxicity>

Answer 5

myelosuppression

Question 6

Cyclophosphamide toxicity

Answer 6

hemorrhagic cysts; use with MESNA

Question 7

Doxorubicin toxicity

Answer 7

Acute and chronic cardiotoxicity

Question 8

Dactinomycin

Answer 8

myelosuppression, hepatic dysfunction

Question 9

Etoposide toxicity

Answer 9

BP instability and hematologic toxicity

Question 10

Ifosamide

Answer 10

Hemmorhagic cystitis- mesna

Question 11

VIncristine

Answer 11

peripheral neuropathy

Question 12

Name the Rapamycins

Answer 12

Temsirolimus and Everolimus

Question 13

What do the Rapamycins do?

Answer 13

Bind FKBP12 and inhibit MTorc-1

Immunosuppresant effects, cell cycle progression inhibitors, promotion of apoptosis

Question 14

How is resistance to Rapamycin thought to be achieved?

Answer 14

By the action of a second, unaffected, mTORD

Question 15

WHat is temsirolimus used for>?

Answer 15

Prolongs survival and delays disease prgresssion in those with poor prognosis.

Question 16

E#verolimus prolongs survival in who>

Answer 16

Patients who failed initial therapy with anti-angiogenic drugs

Question 17

What are side effects of the RAPAMYCINS

Answer 17

rash, mucositis, fatigue, anemia

Watch for shortness of breath and discontinue if noticed.

Question 18

Name the Tyrosine Kinase inhibitors

Answer 18

Sunitinib, Sorafenib, Pazopanib

Question 19

Sunitinib toxicity

Answer 19

fatigue, hypothyroidism, bone marrow suppresion, CHF, Hand Foot

Question 20

Pazopanib TOXICity

Answer 20

HEPATIC DISEASE, CAN BE FATAL.

Question 21

Name the major VEGF inhibitor

Answer 21

Bevacizumab

Question 22

Side effects of bevacizumab

Answer 22

hypertension, increased thromboembolitic events

Question 23

How does IL2 (Aldesleukin) work to treat renal cell carcinoma?

Answer 23

Stimulates a cytokine cascade

Question 24

Toxicity of IL2 Aldeleukin?

Answer 24

Capillary leak syndrome, Decreased organ perfusion, really bad crap

Question 25

IFN Alpha

Answer 25

Has an antiproliferative ffect on the tumor cell

Very weird toxicities, neuropsychatric events and aggressive behavior.