Renal Cancer 4/27/13

Question 1

What is the best means of producing a cure in renal cancer?

Answer 1

Surgical excision

Question 2

When is chemotherapy employed in renal therapy?

Answer 2

When the tumor has a more advanced stage or grade/ if metastasis has occurred.

Question 3

Sites for metastatic growth

Answer 3

Lymph
Lung, Liver, Bone
Brain
Other Kidney
Skin

Question 4

Standard chemotherapy routine for WIlms Tumur?

Answer 4

Vincristine, dactinomycin x 18 weeks
Vincristine, Dactinomycin, doxorubicin x 24 weeks
Vincristine, doxorubicin, cyclophosphamide, etoposide x 24 weeks

Question 5

Clear Cell Sarcoma Therapy?

Answer 5

VDD for 15 mths or VDCE

Question 6

Carboplatin toxicity>

Answer 6

Nephrotoxic, ototoxic, myelosuppression

Question 7

Cyclophosphamide toxicity

Answer 7

Hemorrhagic cystitis (use with mesna), myelosuppression

Question 8

Doxorubicin

Answer 8

Bone marrow suppression, cardiotoxicity

Question 9

Dactinomycin

Answer 9

Hepatic ysfunction, myelosuppresion

Question 10

Etoposide

Answer 10

hematologic toxicity, BP instability

Question 11

Ifosfamide

Answer 11

Bone marrow suppression, hemorrhagic cystitis- MESNA

Question 12

Vincristine, Peripheral neuropathy

Answer 12

true

Question 13

What are the two rapamycins used to treat adult tumors?

Answer 13

Temsirolimus, Everolimus

Question 14

What do Temsirolimus and everolimus do?

Answer 14

immunosuppresants, inhibit cell cycle progression, promote apoptosis

Question 15

What Cytochrome are Temsirolimus and Everolimus metabolized by?

Answer 15

CYP 3A4

Question 16

Sideeffectects of the Rapamycins

Answer 16

Maculopapular rash, mucositis, anemia, fatigue

Question 17

Name the tyrosine kinase inhibitors

Answer 17

sunitinib, sorafenib, pazopanib

Question 18

Fatigue, hypothyroidism, bone marrow suppresion, CHF, Hand foot

Answer 18

Sunitnib side effects

Question 19

Bevacizumab side effects

Answer 19

hypertension, arterial thromboemboic events

Question 20

Aldeslukin IL-2

Answer 20

Stimulates a cytokine cascade, antitumor activity comes from activation of cytotoxic lymphocytes.

Question 21

Side effects of Aldeslukin IL2

Answer 21

Capillary leak syndrome

Question 22

Interferon Alpha side effects

Answer 22

really terrible stuff

Question 23

Clear Cell Sarcoma Therapy for cases involving the brain

Answer 23

ICE….Ifosfamide, Carboplatin, etoposide