Renal biopsy findings

Question 1

Minimal change disease findings?

Answer 1

Effacement of the podocytes (foot processes) on electron microscopy

Question 2

IgA nephropathy

Answer 2

Immunofluorescence shows dominant or co-dominant deposition of IgA

Question 3

Post-infectious Glomerulonephritis?

Answer 3

“Lumpy bumpy” deposits of IgG and C3b on the renal basement membrane.

Question 4

Anti-glomerular basement membrane Antibody disease?

Answer 4

Bright linear deposits of immunoglobulin G (IgG) and complement (C3) on the glomerular basement membrane.

Question 5

hereditary nephritis?

Answer 5

Longitudinal splitting of the lamina densa of the glomerular basement membrane (GBM) on electron microscopy

Question 6

Membranous nephropathy?

Answer 6

“Spike and dome” subepithelial deposits on electron microscopy

Question 7

Membranoproliferative glomerulonephritis

Answer 7

Subepithelial deposits as well as subendothelial deposits in the mesangium and subendothelial space

Question 8

Focal Segmental Glomerulosclerosis

Answer 8

Segmental scarring on light microscopy

Question 9

Vasculitis nephritis?

Answer 9

Mild focal and segmental glomerulonephritis to a diffuse necrotizing and crescentic glomerulonephritis usually without immune deposits (pauci-immune)

Question 10

Amyloidosis in kidney?

Answer 10

Polarized light shows apple-green birefringence, amyloid deposits in the mesangium