Renal Flashcards
Features of Potter’s Syndrome
Pulmonary Hypoplasia Low set ears Beaked Nose Prominent epicanthic folds Downwards slanting eyes Limb Deformity
Mechanism of Multicystic Dysplastic Kidney
Failure of union of the uterine bud with nephrogenic mesenchyme
Management of Multicystic Dysplastic Kidney
50% involuted by aged 2
Nephrectomy indications: very large/ hypertension develops
Causes of large Cystic Kidneys
Autosomal recessive/dominant polycystic Kidney disease
Multicystic Dysplastic Kidney
Tuberous Sclerosis
Presentation of Autosomal dominant polycystic kidney disease
Childhood hypertension
Renal failure in adulthood
Extra Renal feature of Autosomal Dominant Polycystic Kidneys
Cysts in liver and pancreas
Cerebral Aneurysm
Mitral Valve prolapse
Abnormal Caudal migration of the kidneys results in…
Horseshoe kidney or pelvic kidney
Duplex System is due to?
Premature division of the uterine bud
Complications of duplex system
Lower pole moiety- Reflux
Upper pole moiety- Ectopic drainage to urethra or vagina, prolapse into bladder, obstruction urging flow
Features of Absent Musculature Syndrome (Prune Belly)
Wrinkled appearance of abdomen
Large Bladder
Dilated Ureters
Crytorchidism
Site of urinary tract obstruction
Pelviuretric Junction
Vesicoureteric Junction
Bladder Neck
Urethra
Features of bilateral hydronehritis
Hydronephrosis
Hydroureters
Thickened bladder wall
Diverticula
Management of urinary tract anomalies
Start prophylactic antibiotics
US within 24hours, in males with bilateral hydronephrosis
-Normal: US repeat at 2-3 months, stop Abx
-Abnormal: MCUG and surgery
US within 4-6 weeks, in females or unilateral hydronephrosis
- Normal: US repeat at 2-3 months, stop Abx
-Abnormal: Further Ix
Renal Function Assessment in children
Plasma creatinine concentration: eGFR Insulin/EDTA GFR Creatinine Clearance Plasma Urea Concnetration
Radiological Investigation of Kidneys and Urinary Tract
Ultrasound: anatomy
DMSA scan: renal scarring (2 months after UTI- sensitive)
MCUG: detects reflux and urethral obstruction
MAG3 renogram (Children over 4 years): detects reflux, given with furosemide
Plain abdominal X-ray: spinal abnormalities
Features of UTI in infants
Offensive Urine Septicaemia Jaundice Poor Feeding Lethargy Irritability Vomitting Fever Febrile siezure
Features of UTI in children
Secondary Enuresis Dysuria Frequency Urgency Abdominal Pain Loin Tenderness Fever Anorexia Lethargy Vommitting and Diarrhoea Haematuria Cloudy Urine Febrile Seizure
dDx Dysuria
Girls- Cystitis or Vulvitis
Boys- Balanitis (Uncircumcised)
Collection of Urine Samples
Clean catch sample (recommended method) Adhesive plastic bag Urethral catheter Suprapubic aspiration (fine needle inserted above pubic symphysis under US guidance) Midstream sample- Older children
Dipstick Interpretation
Nitrate- positive indicates UTI
Leukocyte- present in fever without UTI, balanitis, and cystitis
Blood/Protein/Glucose- not UTI specific
Predisposing factors UTI
Renal or urinary tract abnormality
Incomplete Bladder emptying
Vesicoureteric reflux
Incomplete bladder emptying factors
Infrequent voiding Vulvitis Incomplete micturition Obstruction from constipation Neuropathic bladder Vesicoureteric reflux
Anatomy of vesicoureteric reflux
Anomaly of vesicoureteric junctions
Ureters displaced laterally
Ureters enter bladder directly
Shorted or absent intramural course
Complications of vesicoureteric reflux
Incomplete Bladder emptying
Increased risk of infection
Risk of pyelonephritis
Renal damage due to pressure transmission
Features Atypical UTIs
Seriously ill or septicaemia Poor urine flow Abdominal or Bladder Mass Raised Creatinine Failure to respond to Abx within 48hrs Non-E.coli organism
Mx UTI Infants <3 months
Immediate referral to hospital
IV Abx .e.g. Co-amoxiclav for 5-7 days
Oral prophylaxis
Mx Pyelonephritis Children >3m
Oral Abx .e.g. Trimethoprim 7days
OR IV Abx .e.g. Co-amoxiclav 2-4 days + oral (total course 7days)
Mx Simple UTI Child >3m
Oral Abx .e.g. Trimethoprim or Nitrofurantoin 3 days
Prevention of UTIs
High fluid intake Regular voiding Complete bladder emptying- sitting on toilet/double voiding Treatment of constipation Good Perineal hygiene Lactobacillus Acidophilus (pro-biotic) Antibiotic prophylaxis
UTI Abx prophylaxis
Children <2-3years with congenital abnormality/upper UTI/reflux
Continue until out of nappies
Trimethoprim 2mg/Kg NOCHE
Follow-up recurrent UTIs, reflux and scarring
Urine dipstick in any non-specific infection
Long term low dose Abx prophylaxis
Circumcision in boys
Anti-VUR surgery in progressive scarring
Annual blood pressure in renal defects
Urinalysis to check proteinuria (CKD)
Regular assessment renal growth and function
Causes of daytime enuresis
Lack of attention to bladder sensation Detrusor instability Bladder neck weakness Neuropathic bladder UTI/Diabetes Constipation Ectopic ureter
Signs of neuropathic bladder
Distended bladder Abnormal perineal sensation Abnormal anal tone Abnormal leg reflexes and gait Sensory loss in S2-S4
Typical Hx of ectopic ureter
Girls who are dry by day but with wetting on morning waking
Pooling of urine from vaginal ureter opening
Ix for daytime enuresis
Urine dipstick, and MCS US- ?incomplete bladder emptying and thickening of bladder wall Urodynamics X-ray- ?vertebral abnormality MRI- ?cord tethering
Mx daytime enuresis
Star charts Bladder training Pelvic floor exercises Constipation treatment Urine alarm Anticholinergics .e.g. Oxybutynin
Causes secondary enuresis
Emotional upset (most common)
UTI
Diabetes (osmotic diuresis)
Renal concentrating disorder .e.g. Sickle cell, CKD, DI
Ix secondary enuresis
UDS- infection, glycosaria, proteinuria
Early morning osmalality
Formal water deprivation test
US renal tract
Physiological proteinuria
Febrile illnesses
After exercise
Normal protein:creatinine
<20mg/mmol early morning sample
Causes of proteinuria
Orthostatic proteinuria Glomerular abnormality: -Minimal change disease -Glomerulonephritis -Abnormal glomerular basement membrane Increased glomerular filtration pressure Reduced renal mass in CKD Hypertension Tubular proteinuria
Features of nephrotic syndrome
Periorbital odema esp. on waking
Scrotal, vulva, leg, ankle odema
Ascites
Breathlessness: abdominal distension and pleural effusion
Infection .e.g. Peritonitis, septic arthritis, sepsis (loss of Ig)
Systemic disease associated with nephrotic syndrome
HSP
Vasculitides .e.g SLE
Infection .e.g. malaria
Allergens .e.g. bee sting
Epidemiology steroid sensitive nephrotic syndrome
Age 1-10 years
More common in boys
Asian children
Associated with atopy
Biochemistry steroid sensitive nephrotic syndrome
No macroscopic haematuria
Normal BP
Normal complement levels
Normal renal function
Management steroid sensitive nephrotic syndrome
Oral corticosteroids .e.g. prednisolone 60mg/m^2 daily
Reduce dose to 40mg/m^2 after 4 weeks alternate days
Wean after 8 weeks
Histology steroid sensitive nephrotic syndrome
Normal on light microscopy
Electron microscopy- fusion of specialised epithelial cells investing glomerular capillaries
Minimal change disease
Complication of nephrotic syndrome
Hypovolaemia
Thrombosis
Infection
Hypercholestrolaemia