Renal Flashcards

1
Q

Which is the most common subtype of bladder cancer?

A

Transitional cell carcinoma

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2
Q

If someone is a long term smoker, which type of renal cancer is strongly linked?

A

TCC

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3
Q

Who is most commonly affected by bladder cancer?

A

Males aged 50-80

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4
Q

How does smoking affect bladder cancer?

A

If someone is a current smoker or has smoked in the past 20 years, they will have a 2-5 fold increase in risk of bladder cancer

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5
Q

Does schistosomiasis affect bladder cancer?

A

If someone has chronic inflammation due to schistomsomiasis, then this is a common cause of bladder cancer in countries where it is endemic

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6
Q

What are the types of bladder malignancies?

A
  • Transitional cell carcinoma (>90% of cases)
  • Squamous cell carcinoma ( 1-7% -except in regions affected by schistosomiasis)
  • Adenocarcinoma (2%)
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7
Q

If you have T3 BCC what is your risk of lymph node metastasis?

A

Over 30%

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8
Q

What is the presentation of bladder cancer?

A

85% present with painless, macroscopic haematuria.

With microscopic haematuria, up to 10% of females over 50 will be found to have a malignancy post exclusion of infection

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9
Q

How is bladder cancer treated?

A

If superficial lesions, then TURBT.
If it is recurrant or a higher grade/risk, then intravesical chemotherapy may be offered.
T2 and over are usually offered surgery or radical radiotherapy

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10
Q

What is the prognosis of bladder cancer?

A
T1	90%
T2	60%
T3	35%
T4a	10-25%
Any T, N1-N2	30%
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11
Q

What are the different make ups of ureter stones?

A
Calcium oxalate (85%)
Cystine (1%)
Uric acid (5-10)%
Calcium phosphate (10%)
Struvite (Mg, NH4 and phosphate) (2-20%)
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12
Q

Which shapes are which stone make-ups?

A
Calcium oxalate - envelope shaped
Cystine - hexagonal
Uric acid - diamond/rhomboid
Calcium Phosphate - wedge
Struvite - coffin lid
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13
Q

Which type of stone does dehydration predispose your risk to?

A

Calcium oxalate

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14
Q

Which type of stone does repeat UTIs give you the risk of?

A

Struvite

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15
Q

Where do the renal arteries come off the aorta?

A

L2

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16
Q

Which aromatic amines are used in the manufacture of dyes?

A

2-naphthylamine and benzidine

17
Q

What are the risk factors for TCC?

A
  • smoking
  • exposure to dyes
  • rubber manufacture
  • cyclophosphamide
18
Q

What are the risk factors for squamous cell carcinoma of the bladder?

A
  • schistosomiasis
  • smoking
  • BCG treatment
19
Q

What is Alport syndrome?

A

Alport Syndrome (AS) is a disorder of the glomerular basement membrane. It is the second most common cause of CKD. It is a mutation of type 4 collagen and can affect the ear and the eyes as well.

20
Q

What is Goodpasture syndrome?

A

It is an autoimmune disorder of the kidney and lungs in which antibodies affect the basement membrance of both the kidney and lungs.

21
Q

What important side effect does indapamide have?

A

(loop diuretic)

sexual dysfunction