Renal Flashcards
1
Q
Functions of renal system
A
- Excretion of metabolic products
- Fluid and electrolyte balance
- Acid-base balance
- Ca + PO4 homeostasis
- Vit D metabolism
- EPO and red blood cell production
2
Q
Nephrotoxic drugs
A
- Abx- gentamicin, vancomycin
- NSAIDs- inhibition of prostaglandins reduce renal blood flow they also cause tublar interstitial nephrititis
- Antifungals
- Anti-htn
- Immunomodulators- ciclosporin
- Lithium
3
Q
A
4
Q
Drug toxicity
A
- Think of therapeutic index (concentration range between efficacy and toxicity)
- As accumulation occurs this will push up plasma concentration and increase
5
Q
A
6
Q
some common intrarenal AKI causes (meds)
A
Glomerulonephritis - penicillin, phenytoin
Nephritis – penicillin, NSAIDs, diuretics
Acute tubular necrosis - Aminoglycosides, Amphotericin and Ciclosporin
