Renal 1 Flashcards
glomeruli histology
Network of capillaries between afferent arteriole (bringing blood to the capillary bed) and efferent arteriole (drains blood away from capillary bed). The capillary wall consists of endothelium, basement membrane and epithelium (lining the urinary space). The epithelial cells have many finger-like processes that come from the cell body and contact the basement membrane. A membrane connects adjacent processes (called the slit diaphragm) and is important in preventing proteinuria. The capillary wall is permeable to water and small molecules and impermeable to albumin and larger proteins. The capillaries are supported by connective tissue called the mesangium.
tubule histology
The filtrate from the glomeruli travels through the system of tubules. The tubular epithelium reabsorbs some substances and secretes other substances, eventually forming urine
interstitium histology
Formed by collagen and blood vessels between the tubules and glomeruli.
vasculature histology
The efferent arterioles supply the capillary bed around some of the tubules (vasa recta). Absence of blood flow through the glomeruli reduces oxygen delivery to the tubules.
azotemia
Elevation of the blood urea nitrogen (BUN) and creatinine levels, due to decreased filtration of blood through the glomeruli (decreased glomerular filtration rate).
uremia
Association of azotemia with clinical signs and symptoms, including gastroenteritis, peripheral neuropathy, pericarditis, dermatitis, hyperkalemia, and metabolic acidosis.
acute nephritic syndrome
Results from glomerular injury and is characterized by acute onset of hematuria, mild to moderate proteinuria, azotemia, and hypertension.
nephrotic syndrome
Glomerular syndrome characterized by heavy
proteinuria (> 3.5 grams per day), hypoalbuminemia, severe edema, hyperlipidemia, and lipiduria.
acute renal failure
Acute onset of azotemia with oliguria (or anuria).
Autosomal dominant (adult) polycystic kidney disease Clinical presentation
seen in 1 out of every 500-1000 people,
characterized by multiple expanding cysts in both kidneys. Gradual onset of renal failure in adult, urinary tract hemorrhage (hematuria), pain, hypertension, urinary tract infection.
Autosomal dominant (adult) polycystic kidney disease etiology
defective gene is PKD1 (in 90% of families) located on chromosome 16. The gene encodes for polycystin-1
Autosomal dominant (adult) polycystic kidney disease Extrarenal pathology
1/3 of patients have cysts in liver; aneurysms
may develop in the circle of Willis (intracranial)
saccular (“berry”) aneurysms affecting circle of Willis (30%)
Autosomal dominant (adult) polycystic kidney disease Pathology
very large (up to 4 kg) kidneys with numerous cysts that
arise in every part of the tubular system
•Histopathology
–Cysts arise from all levels of the nephron
•Clinical: flank pain around 4th decade, hematuria, hypertension and UTI, renal failure
Autosomal recessive (childhood) polycystic kidney disease clinical
renal failure develops from infancy to several years of age – rare; seen in 1 in 20,000 live births. Due to mutations in the PKHD1 gene
•Defective protein: fibrocystin
Autosomal recessive (childhood) polycystic kidney disease Extrarenal pathology
almost all have liver cysts and progressive liver fibrosis