Renal 1 Flashcards
What are the functions of the kidneys? Examples?
Excretory
Filtration, secretion, (reabsorption), excretion
Endocrine
Renin, prostaglandins, kinins, erythropoeitin
Metabolic
Vitamin D activation, gluconeogenesis, insulin metabolism
What is renal functionsummarized as? (Roles of the kidney)
excretion + endocrine + metabolic functions
What are the excretory functions of the kidney?
Regulate fluid, electrolyte, and acid-base balance
Remove metabolic waste products & foreign chemicals from blood for urinary excretion
How are the excretory functions of the kidney accomplished?
Filtration
Reabsorption
Secretion
Describe glomerular filtration
Blood enters the glomerulus through the afferent arteriole
Glomerular filtration: Blood is filtered by hydrostatic pressure through the capillaries that form the glomerulus into the Bowman capsule (Non-selective process)
Blood leaves the kidney through the efferent arteriole
How much of filtrate is composed of the plasma? Composition of Filtrate (Basic)
The filtrate is composed of ~20% of the plasma entering the glomerulus
Composed mainly of fluids, electrolytes, small molecules
Excludes proteins and large molecules (e.g., blood cells, albumin)
Composition of Filtrate (Specific). Exceptions?
Glucose
Amino acids
(Undergo re-absorption; should see minimal amounts in urine under normal circumstances)
Electrolytes
Water
Urea
Uric acid
Creatinine
Protein (no large proteins; under normal circumstances there will be some proteins)
Describe the process of reabsorption
The movement of substances OUT of the renal tubules back INTO the blood capillaries
FILTRATE → BLOOD
Purpose of Reabsorption
Prevents substances needed by the body from being lost in the urine
What molecules are reabsorbed by the kidney?
Reabsorption of water and solutes including:
NaCl, K+, HCO3-, urea, amino acids, glucose
100% of glucose and amino caids should be reabsorbed
Describe glucose reabsorption in diabetics
Under normal physiological conditions 100% of glucose should be reabsorped
In diabetics, the amount of glucose in the blood and ultimately filtrate exceeds the capacity to be reabsorped
Describe the process of Na+ and H20 reabsorption
Water reabsorption occurs through an osmotic gradient
Where Na+ goes, H2O will go with it
How much of the filtrate is excreted in the urine?
Less than 1% of the filtrate is excreted
Describe the process of secretion
Substances move OUT of the blood and INTO the tubules where they mix with the water and other wastes and are converted into urine
BLOOD → FILTRATE
What substances undergo secretion?
Substances secreted include: H+, K+, uric acid, certain drugs
How are substances secreted?
Active transport mechanism (e.g., P-glycoprotein)
Diffusion across the membranes
Where in the kidney does reabsorption occur?
Bulk reabsorption, which is not under hormonal control, occurs largely in the proximal tubule.
Regulated reabsorption occurs in the collecting duct
Where does secretion occur in the kidney?
Proximal Tubule
Regulated Secretion Collecting Duct
Describe acid base balance in the body?How is this accomplished by the kidneys?
Body maintains pH within a narrow range (7.35-7.45) by regulating H+ concentration
Accomplished through filtration, reabsorption, secretion in kidney
What are some mechanisms of H+ concentration regulation in the body?
Mechanisms of H+ concentration regulation:
Lungs: alveolar ventilation of carbon dioxide
Kidney: hydrogen ion excretion, bicarbonate reabsorption, phosphate and ammonia buffer systems
Kidneys Regulation of acid base balance
Kidney is responsible for secreting acids (H+)
Kidney is responsible for reabsorbing bicarbonate (HCO3-)
How does the kidney respond to acidosis?
In response to excess acid, kidneys reabsorb all filtered bicarbonate and produces new bicarbonate
How does the kidney respond to alkalosis?
In response to too little acid, kidneys excrete bicarbonate to restore H+ concentration to normal
Examples of of specific substance excretion by the kidney
Responsible for the excretion of waste products produced from protein metabolism (uric acid) and from muscle contraction (creatinine)
Renal elimination of certain drugs
Removed by filtration and/or secretion
Briefly describe the endocrine functions of the kidney
Produces hormones involved in:
Blood pressure control
RBC production
What are some key mechanisms of renal blood pressure mechanisms?
Renin-Angiotensin-Aldosterone System (RAAS)
Antidiuretic hormone (ADH)
Atrial natriuretic peptide (ANP)
What is the main mechanims by which kidneys control blood pressure?
RAAS System
Describe the RAAS system?
Main mechanism by which the kidneys control blood pressure
For filtration to occur, hydrostatic blood pressure must be at a certain value
Renin is released from renal juxtaglomerular cells in response to decreased blood pressure
Indirectly, renin leads to:
Vasoconstriction
Sodium and water retention
Draw out the RAAS system?
What is the role angiotensin II?
Angiotensin II evokes vasoconstriction of the efferent arteriole, to increase glomerular hydrostatic pressure
What other important endogenous compounds maintain blood pressure? How?What do they also promote?
Prostaglandin E2 and I2
Produced by the kidney in response to decreased blood flow
Cause vasodilation, specifically of the afferent arteriole, to increase renal perfusion
Also promote the secretion of renin
Describe the relationship between renal function and NSAIDs?
Prostaglandin E2 and I2
Cause vasodilation, specifically of the afferent arteriole, to increase renal perfusion
–> Why NSAIDs decrease kidney function
–> NSAIDS limit the vasodilation leading to less blood flow
What is aldosterone? What is its mechanism?What are some other functions?
Secreted by the adrenal cortex in response to Angiotensin II
Primary role is to stimulate tubule reabsorption of sodium
This means sodium (salt) moves OUT of the kidney/renal tubule and INTO the blood/body
Wherever salt goes, water follows –> BP goes up
Indirectly:
Increases potassium excretion
Increases H+ excretion
What is antidiuretic hormone (ADH)? Mechanism?
Secreted by the posterior pituitary in response to increased blood sodium levels / low blood volume
Increases water permeability of the collecting ducts, promoting water reabsorption
Means water is going BACK into the BLOOD instead of being peed out
Thus, the kidney excretes a more concentrated urine (antidiuresis)
What is atrial naturietic peptide (ANP)?
Stored in the right atrium of the heart
Released in response to increased stretch of the heart muscle
Indicative of fluid overload
Elevated in heart failure
Opposes the actions of RAAS by causing vasodilation and increased renal excretion of sodium (opposite effect of aldosterone)
How do the kidneys regulate RBC production?
ERYTHROPOIETIN
Stimulates production of red blood cells (increase oxygen-carrying capacity of the blood)
90% produced in the kidneys by peritubular interstitial cells
Produced by the kidneys in response to decreased blood oxygen levels (anemia, hypoxia, etc.)
Deficient/lack of erythropoeitin production in chronic kidney disease (CKD) leads to anemia
What are the metabolic functions of the kidney?
Metabolism of endogenous compounds (e.g., insulin)
Vitamin D activation
Gluconeogenesis
Describe the process of vitamin D synthesis in the kidneys?
Describe vitamin D activation by the kidneys?
Vitamin D has to be activated by the liver and then the kidney before it can exert its effect
Cholecalciferol → calcidiol → calcitriol
In CKD, vitamin D activation is impaired
Leads to disruption of the calcium-phosphorus-parathyroid hormone balance and renal bone disease
Describe the process of gluconeogenesis in the kidney?
To make glucose from amino acids
Most of gluconeogenesis occurs in the liver, but some also occurs in the cortex of the kidney
Why do pharmacists check renal function?
Monitoring and early recognition of CKD
–> Monitoring the effect of drugs on slowing progression
–> Predict the time to onset of ESRD
–> Evaluating risk of complications
To adjust doses of medications excreted by the kidneys (renal dose adjustments)
Monitoring nephrotoxic medications
What is creatinine?
a by-product of muscle metabolism that is primarily eliminated by glomerular filtration
What is serum creatinine?
Concentration of creatinine in the blood
Endogenous substance
A way to measure the filtration rate
When GFR is low, SCr is increased
What does MDRD measure?
measures the GFR
What does CKD-EPI measure?What is it used for?
Glomerular filtration rate, new improved version of MDRD, more accurate estimates especially when GFR is >60 ml/min
Used for classifying the severity of kidney dx
What does the cockcroft-gault equation measure?
Creatinine Clearance; not GFR
What does the salazar corcoran measure?
Creatinine Clerance for Obese patients
What equation is used for making renal dose adjustments for medications?
Cockcroft-Gault most common measure for renal dose adjustments; increasing popularity to use eGFR for renal dose adjustments (more accurate estimate of someone’s true ability to eliminate drugs through the kidneys)
Need to be manually calculating when using Cockcroft-gault
T/F: The CKD-EPI equation is used to estimate kidney function in a patient receiving dialysis
False