REN drugs Flashcards
What drug blocks hydrogencarbonate absoption
Acetazolamide
Where in the kidneys does Acetazolamide target
Acts mainly in the proximal tubule
How does acetazolamide work
Blocks carbonic anhydrase
Can acetazolamide be used a direuetic
Yes, it is a weak one
acts in later parts of tubule, and can retain the bicarbonate
What are the uses of acetazolamide
glaucoma, mountain sickness prophylaxis
Why do we use acetazolamide for altitude sickness
-the drug can cause metabolic acidosis
-because when we are at altitude
-we get respiratory alkalosis because the partial pressure of o2, is lower
-so we ventilate more
-in doing so we lose co2.
-Anyways we give this before you climb a mountain because this causes acidosis
-which will counteract with alkalosis caused by high altitude
What is a problem with acetazolamide
The pH of urine will become alkaline → leading to metabolic acidosis
Does caffine have a diuretic effect
Yes
How does caffine have a diuretic effect
it works on the adenosine recpetor
so if increase GFR, we inhibit sodium ion reabsoption, so we get a diuresis
Name a widely used potent diuretic
Furosemide
How does furosemide work
Acts in the ascending limb of Loop of Henle (so its a “loop” diuretic)
- Blocks Na+/K+/2Cl- co-transporter
- stops salt moving, so stops water being rebasoped,
- which causes diuresis
- Allows up to 20% of filter Na+ to be excreted, causing enormous natriuresis (losing sodium) and diuresis.
Why do we use furosemide
Uses: cardiac failure, renal failure
What are the side effetcs of furosemide
- K+ loss (and subsequent hypokalemia), leading to cardiac dysrhythmias (particularly when administered with digoxin)
- CVS: link prolong time for AP, so that (check that out)
Other side effects:
- Hypovolaemia (assessed by acute weight changes)
- Mild metabolic alkalosis (distal Na+/H+ exchange)
- Loss of Mg2+ and Ca2+ (loss of filtrate +ve charge).
What do Thiazides do
- Block Na+/Cl- co-transporters
- stops ions from being reabsorbed, which means less water is reabsorbed
Where do thiazides work
Act in the distal tubule
its a moderately effective diuretics
