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immunology hard things to remember > Remember > Flashcards

Remember Flashcards

1
Q

A3

A

Hemochromatosis

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2
Q

B8

A

Addison disease

Myasthenia gravis

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3
Q

B27

A

Psoriatic arthritis
Ankylosing spondylitis
IBD associated arthritis
Reactive arthritis (Reiter sx)

PAIR seronegative arthropathies

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4
Q

DQ2 DQ8

A

Celiac disease

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5
Q

DR2

A

Multiple sclerosis
SLE
Hay fever
Goodpasture sx

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6
Q

DR3

A 
Diabetes mellitus type 1
SLE
Graves' disease 
Hashimoto thyroiditis
Addison disease
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7
Q

DR4

A

Rheumatoid arthritis
DM1
Addison disease

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8
Q

DR5

A

Pernicious anemia

Hashimoto thyroiditis

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9
Q

Opsonization

A

C3b IgG

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10
Q

Anaphylaxis

A

C3a c4a c5a

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11
Q

Neutrophil chemotaxis

A

C5a

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12
Q

MAC membrane attack complex

A

C5b-9

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13
Q

Complement Inhibitors

A

CD55(decay accelerating factor) and C1

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14
Q

IL1

A

Fever

Activates endothelial to express adhesion molecules

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15
Q

IL2

A

Stimulate differentiation of Th activates NK cell monocytes
Stimulates B cell division

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16
Q

IL3

A

Stimulates bone marrow

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17
Q

IL4

A 
Stimulates differentiation to Th 2
Enhance class switching to IgE and IgG
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18
Q

IL 5

A 
Enhance class switching to IgA
Th2 growth and differentiation of eosinophils
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19
Q

IL6

A

Stimulates acute phase reactants

Fever

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20
Q

IL 8

A

Neutrophil chemotactan

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21
Q

IL 12

A

Differentiate Th1

Activaste natural killers

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22
Q

TNF alpha

A

Cachexia in malignancy
Mediates septic shock
WBC recruitment

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23
Q

INF gamma

A

Stimulates macrophages
Activaste NK
Use: Chronic granulomatous disease

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24
Q

IL10

A

Attenuates inflammatory response

Also with TGF Beta

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25
Q

Anti basement membrane

A

Goodpasture sx

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26
Q

Anticardiolipin - lupus anticoagulant

A

SLE and antiphospholipid sx

27
Q

Anticentromere

28
Q

Anti-desmoglein (anti desmosome)

A

Pemphigus Vulgaris

29
Q

Anti dsDNA - anti smith

30
Q

Antihemidesmosomes

A

Bullous pemphigoid

31
Q

Anti-histones

A

Drug induce SLE

32
Q

Anti-Jo-1 anti SRP Anti Mi2

A

Polymyositis

Dermatomyositis

33
Q

Antimicrosomal antithyroglobulin

A

Hashimoto thyroiditis

34
Q

Antimitochondrial

A

1 biliary cirrhosis

35
Q

ANA (antinuclear)

A

Non specific

SLE

36
Q

Anti-parietal cell

A

Pernicious anemia

37
Q

Antiphospholipase A2 receptor

A

1 membranous nephropathy

38
Q

Anti-Scl-70 (antiDNA topoisomerasa I)

A

Scleroderma

39
Q

Anti-smooth muscle

A

Autoimmune hepatitis type I

40
Q

Anti Ro Anti La (anti SSA anti SSB)

A

Sjogren sx

41
Q

Anti TSH receptor

A

Graves’ disease

42
Q

Anti-Ribonucleoprotein (RNP)

A

Mix connective tissue disease

43
Q

Voltage gated calcium channel AB

A

Lamber Eaton sx

44
Q

IgA antiendomisial IgA anti tissue transglutaminase

A

Celiac disease

45
Q

p-ANCA (MPO ANCA)

A

Microscopic polyangiitis

Churg- strauss sx

46
Q

c-ANCA (PR3 ANCA)

A

Wegener granulomatosis

47
Q

Rheumatoid factor

A

RA
IgM ab targets IgG Fc region
Anti CCP (anticitrulinated peptide) more specific

48
Q

Aldesleukin (IL2)

A

Uses: Renal cell carcinoma metastatic melanoma

49
Q

Epoietin alpha (erythropoietin )

A

Uses: Anemia (specially in renal failure)

50
Q

Recovery of bone marrow

A

Filgrastim (G-CSF)

Sargamostin (GM-CSF)

51
Q

INF - alpha

A

Uses: chronic HBV HCV kapossi sarcoma malignant melanoma

52
Q

INF beta

A

Multiple sclerosis

53
Q

Thrombocytopenia

A

Romiplostin eltrombopag (thrombopoietin receptor agonist )

Oprelvekin (IL 11)

54
Q

Alemtuzumab

A

Target CD52

Use CLL MS

55
Q

Bevacizubam

A

Target VEGF

Use colorectal cancer Renal cell carcinoma

56
Q

Cetuximab

A

Target EGFR

Use stage IV colorectal cancer head neck cancer

57
Q

Rituximab

A

Target CD20

Use B-Cell non-Hodgkin lymphoma CLL RA ITP

58
Q

Trastuzumab

A

Target HER2/neu

Uses: Breast cancer

59
Q

Eculizumab

A

Target complement protein C5

Uses: paroxysmal nocturnal hemoglobinuria

60
Q

Natalizumab

A

Target alpha-4 integrin

Uses: MS chron disease

61
Q

Andalizumab
Certolizumab
Infliximab

A

Target: TNF alpha

Uses : IBD RA ankylosing spondylitis psoriasis

62
Q

Etanercept

A

TNF alpha receptor

Uses RA Psoriasis ankylosis spondylitis

63
Q

TGF Beta function

A

Tissue regeneration and repair

immunology hard things to remember (1 decks)

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