Regulatory Tox

Question 1

what is the equation for the determination of safety

Answer 1

risk=hazard(toxicity)*(exposure)

Question 2

define hazard assessment

Answer 2

involves the identification and description of the toxicological features of a substance

Question 3

describe dose/exposure response evaluation

Answer 3

very high exposure levels likely do not reflect the risks that would be expected out typically and actual field exposure levels

Question 4

how are carcinogens characterized

Answer 4

characterized by a ‘no threshold” dose response relationship

Question 5

what is the no threshold dose relationship

Answer 5

there will always be some level of risk, even if it can’t be directly measured (at every level of exposure)

Question 6

describe group 2 carcinogens

Answer 6

2a) probably

2b) possibly

Question 7

describe group 3 carcinogens

Answer 7

the agent is not classifiable as to its carcinogenicity to humans

Question 8

describe group 4 carcinogens

Answer 8

not likely to be carcinogenic

Question 9

what is teratogenicity

Answer 9

property of a chemical which causes permanent structural or functional abnormality during embryonic development

Question 10

what is NOAEL

Answer 10

highest dose that doesn’t give any adverse effects

Question 11

what is ADI

Answer 11

acceptable daily limit (more conservative than NOAEL)

Question 12

what are the assumptions in determination. of food safety

Answer 12

• all commodities always contain the pesticide residue
• the residue is always present at the max permitted level
• consumers only eat commodities containing residues
• dietary exposure to it will occur everyday of life