Regulation of Purine Synthesis

Question 1

Where does most of the regulation occur?

Answer 1

• PRPP production.
• Commitment Step.
• IMP differentiation.

Question 2

What are the key Enzymes in Purine feedback inhibition in order?

Answer 2

1. PRPP Synthetase.
2. Glutamine PRPP Amidotransferase.
3. Adenylosuccinate Synthetase and IMP Dehydrogenase

Question 3

What is the mechanism by which the cell brings AMP and GMP levels to equivalency?

Answer 3

High levels of ATP facilitate GMP production.

High levels of GTP facilitate AMP production