Regulation of Pathways

Question 1

What up and down regulates Pyruvate Dehydrogenase Complex

Answer 1

Up: NAD+ ADP AMP Ca2+ CoA
Down: Succinyl CoA, NADH, ATP, Citrate, Fatty Acids

Question 2

What Up and Downregulates citrate synthase

Answer 2

Up: ADP
Down: Citrate,NADH, ATP, Succinyl CoA

Question 3

What up and down regulates isocitrate dehydrogenase?

Answer 3

Up: Ca2+, ADP
Down: ATP

Question 4

What up and down regulates alpha ketoglutarate dehydrogenase?

Answer 4

Up: Ca2+
Down: Succinyl CoA, NADH

Question 5

What is the role of FOXO1 and how is it regulated?

Answer 5

FOXO1 activates PEP carboxykinase and glucose-6-phosphatase, it is broken down when insulin binds

Question 6

What molecules Up and Down Regulation PP1?

Answer 6

Up:Insulin, G-6-P, Glucose
Down:Glucagon, epinephrine