Regulation of Metabolism Flashcards
The products produced in the glutamate synthase pathway can feedback to inhibit the pathway. What are the 6 products produced?
AMP, CTP, Tryptophan, Histidine, Carbamoyl phosphate, and Glucosamine 6-phosphate.
What two amino acids are inhibitors of the glutamate synthase pathway?
Glycine and Alanine.
What is ‘concerted inhibition’?
It is where the product of a reaction can inhibit both the first committed step of the pathway and the enzymes involved.
What are the 3 precursors Histidine is derived from?
PRPP, ATP and Glutamine
Name 2 purines that are basic (as opposed acidic).
Adenine and Guanine.
Name 3 pyrimidines that are basic (as opposed to acidic).
Cytosine, Uracil, and Thymine
What is a nucleoside?
A nucleoside is a base bound to either a ribose or deoxyribose sugar via a β-glycosidic linkage.
What is a nucleotide?
A nucleotide is a nucleoside (base and sugar) bound to a phosphate group.
What is different between a ribose-nucleotide and deoxyribo-nucleotide?
A ribose-nucleotide would have a -OH on their C2 rather than H.
(deoxyribose-nucleotide has H on their C2).
What does the synthesis of AMP and GMP require?
AMP requires GTP.
GMP requires ATP.
What 3 molecules can inhibit the synthesis of PRPP?
IMP, AMP and GMP.
What is IMP (inosine monophosphate) derived from?
PRPP.
What does IMP (inosine monophosphate) produce
AMP and GMP.
In bacteria, the pyrimidine CTP can be produced from Aspartate. How can its synthesis be inhibited?
CTP can feedback to inhibited aspartate transcarbamoylase.
What is carbamoyl phosphate?
It is an anion present in the cytosol used to make pyrimidines.
