reflexes, pain, motor control Flashcards

1
Q

patellar reflex -
describe the pathway
the point of this reflex and it’s broader name

A

afferent sensory fibre to dorsal root ganglion
direct synapse with motor neuron in ventral horn
synapses at muscle
point = stretching the extensor muscle and associated tendon causes stretching that must be corrected

broader name is the stretch reflex - pouring a drink, arm doesn’t as drink gets heavier as an example

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2
Q

stretch reflex - what is the other part of the circuit?

A

sensory neuron also talks to an interneuron, which talks to a motor neuron to inhibit the other muscle from counteracting the reflex

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3
Q

muscle spindle - where?
what does it do?
include details on the neurons used?

A

found in striated muscle
the extrafusal muscle like the bicep or whatever, the home of the muscle spindle, is innervated by alpha motor neuron

spindles slacken when muscle contracts, Ia sensory fibres aren’t firing
when stretched the spindle is tight and lets you know the end point

muscle fibre - innervated by gamma motor neurons - adjust the tension

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4
Q

golgi tendon organ - what do they do and what neurons do they activate?

A

they detect muscle tension, not stretch

sensory Ib fibres actiavted by too much tension, GTO causes inhibitory neurons to inhibit the alpha neurons of that msucle to prevent you from over doing it

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5
Q

flexor/withdrawal reflex?
what is it?
poly or monosynaptic?
parallele after-discharge circuit?

A

jerks a limb away from something painful
polysynaptic
parallel after discharge = looks like a parallel circuit from physics, with different number of sunapses so info arrives in succession not at once, sustains response

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6
Q

contralateral element of withdrawal reflex?

A

prepares other leg to take weight

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7
Q

what are repetitive behaviours? Like in walking, alternating the pattern of flexion and extension

A

Like in walking, alternating the pattern of flexion and extension when walking, plus alternating sides - can happen with severed spinal cord
stretch receptors involved

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8
Q

sensory receptors - encapsualted?

A

meissner/tactile corpuscles - light touch and texture, found in palms and eyelids, lips and tongue etc… 30-50Hz, these are rapidly adapting

Pacinian corpuscles - detect deep pressure, vibrations, tickles 250-350Hz, these are rapidly adapting

Ruffini corpuscles - actually a kind of proprioceptor - located in the dermis, subcutaneous tissue - detect deep pressure, skin stretch, joint movements, these are slow adapting

Capsules are involved in ‘filtering’ so that different cells respond to different frequencies and we can differentiate between types of touch

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9
Q

unencapsulated sensory receptors?

A

merkel/tactile cells/discs - light touch, edges and texture
Free nerve endings - pain, heat and cold, widespread in the epithelia

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10
Q

rapid and slow adapting meaning?

A

rapid = when stimulus starts, desensitises?
slow = tonic, persistent

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11
Q

how are axons classified?

A

A B C where A is fastest/largest, alpha to delta subdivisions alpha fastest

muscles use roman numerals I - IV

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12
Q

what axons do 1) pain 2) proprioception

use?

A

1) = C
2) = Aa

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13
Q

medial lemniscal tracts carry…

A

mechano and proprioceptive signals to the thalamus

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14
Q

spinothalamic tract…

A

pain and temperature to spinal cord

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15
Q

medial leminiscal - is lower or upper body more medial in the spinal cord and how is topology preserved?

A

lpwer is medial/gracile nucleus, upper is lateral/cuneate nucleus

2nd order neurons cross midline, making upper the more medial, so the htird order neurons must cross again to preserve topology in the brain

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16
Q

what is the specificity theory of pain?

A

pain is a distinct sensation, detected and transmitted by specific receptors and pathways to distinct areas of the brain

17
Q

what is the convergence theory of pain?

A

that pain is an integrated, plastic state represented by a pattern of convergent somatosensory activity within a distributed network (a so-called ‘neuromatrix’)

18
Q

two types of afferent fibres for nociceptors?

A

Ad fast myelinated
C unmyelinated slow

19
Q

example of a molecular pain receptor?

A

TRPV1 for capsaicin
also responds directly to heat

20
Q

what are the two central pathways for pain?

A

Sensory-discriminative - signals location, intensity and type of stimulus
Affective-motivational - signals unpleasantness and enables autonomic activation - fight or flight response

21
Q

what is hyperalgesia

A

Result of lowered nociceptor thresholds
Tissue damage releases a ‘soup’ of inflammatory responses that affect your nerve function and increase local blood flow
super sensitive

22
Q

central hyperalgesia?

A

Centrally - hyperplasia can also arise due to release of substances l;ike prostaglandin form the dorsal horn nociceptive neurons

23
Q

allodynia?

A

allodynia:
Painful response to something not normally painful - e.g. you’re sunburnt, a gentle brush of the skin is now painful when it wasn’t before
Mechanoreceptors - not for pain - hypersensitized by these molecules release by damaged tissues like prostaglandins

24
Q

central allodynia?

A

nociceptive neurons influenced by mechanoreceptive neurons so mechanic sstimuli = painful

25
Q

hyperpathia?

A

nerve damage raises threshold, if met pain is explosive