References Flashcards
(175 cards)
1
Q
The significant contribution of NMDA to E rev at physiological concentrations
A
Jahr and Stevens 1993
2
Q
AMPA/Kainate receptor tetramers
A
Rosemund 1998
3
Q
NMDA receptor tetramers
A
Laube 1998
4
Q
Kainate-Rs dual mode of action
A
Melyan 2002
5
Q
MGluR structure
A
Conn and Pin 1997
6
Q
First report of toxic effect of LGlu
A
Lucas and Newhouse 1957
7
Q
Term excitotoxicity
A
Olney 1971
8
Q
Acute LGlu Excitotoxicity
A
Rothman 1985
9
Q
Delayed L-Glu excitotoxicity
A
Choi 1987
10
Q
Slow excitotoxicity
A
Larm et al 1997
11
Q
Apoptotic, intermediate hybrid and nectrotic cells
A
Martin 1998
12
Q
Mg used for epilspsy but not good for stroke
A
Saver 2015, Shkirkova 2017
13
Q
Blocking NMDARs in 8 day old rat
A
Ikonomidou 1999
14
Q
Post-natal brain more susceptible to NMDA induced excitotoxicity
A
Zhou and Baudry 2006
15
Q
Apomorphine reversed reduction in cerebral blood flow associated with hypofrontality
A
Daniel et al 1989
16
Q
Vervet monkeys given PCP
A
Jentsch et al 1997
17
Q
GluN1 kockdown mice
A
Mohn et al 1999
18
Q
Dual agonism of NMDAR by glycine
A
Johnson and Ascher 1987
19
Q
Injected receptor mRNAs into xenopus oocytes
A
Kutsuwada 1992 and Ishii 1993
20
Q
HIgh doses of glycine and lower with antipsychotics improve negative symptoms
A
Heresco-Levy 1999 and 2004
21
Q
D-serine as effective as glycine
A
Tsai et al 1998 and Heresco-Levy 2005
22
Q
Glycine and clozapine have no improvement perhaps due to occlusion
A
Evins 2000
23
Q
Sacrosine
A
Tsai 2004
24
Q
Bitopertin
A
Kingwell 2014
25
Iclepertin
Fleischhacker 2021
26
Endogenous KYNA mimics actute effects of PCP on the VTA
Erhardt and Enberg 2002
27
40-50% increase of KYNA in CSF of SZC subjects
Linderholm 2012
28
Decreased KYNA levels in rats improved cognitive function
Kozak 2014
29
Humans have lower brain volume etc in depression
Kang 2012
30
Mice have reduced dendritic spines etc in depression
Liu and Aghajanian 2008
31
Humans have decreased AMPA-R GLuA2 and 3 in depression
Beneyto 2006
32
Humans have increased extracellular glutamate in depression
Hashimto 2007
33
Animals have less AMPA and NMDA mediated responses and receptor subunit expression in depression
Yuen 2012
34
Increased inhibition and decrease synaptic LGlu release in mice with depression
McKlveen 2016
35
Decrease LGlu uptake in mice with depression
De Vasconcellos-Bittencourt 2011
36
Increased spine numbers to control after single dose of K
Li 2011
37
More glutamate receptor trafficking and protein synthesis after K
Cao 2024
38
Antidepressent behaviour sustained in FST and LH 2 weeks after K
Maeng 2008 and Autry 2011
39
Mimicked by MK-801 and deletion of GluN2 occludes K effect in FST
Maeng 2008, Li 2010, li 2011, Autry 2011 ans Miller 2014
40
Ketamine action blocked by NBQX in FST
Maeng 2008
41
Increased AMPA trafficking and insertion after K
Li 2010, 2011 and Zhang 2016
42
Increased Phosphorylation of Rapamycin and mTOR activation
Li 2010 and 2011
43
Reduced K effect in trafficking impaired knock in mice for BDNF
Liu 2012
44
Reduced K effect in kock out BDNF mice
Autry 2011
45
Disinhibition ketamine theory
Duman group
46
Direct postsynaptic action ketamine theory
Kavalalli group
47
Associated hypofrontality with negative symptoms of SCZ using PET
Weinberger 1986
48
Who pioneered research into mini ischaemic strokes?
Fisher 1962
49
Discovery of the TCA cycle
Krebs 1953
50
Development of the NMJ
Borges and Richman 2020
51
Demonstrated enzyme activity degrading ACh (AChE)
Feldberg and Quastel 1930s
52
Found that there was another cholinersterase that was not AChE
Spiro and Knoop 1925-30s
53
Discovery of ACh
Loewi 1921
54
Demonstration that ACh is released when the motor nerve is stimulated
Dale 1936
55
Receptors mediating the responses of cells to transmitters
Langley
56
Muscular nicotinic receptor structure
Cetin 2020
57
Various ACh receptor configuration broadly distributed in the brain
Taly 2009
58
Generated anibodies to purified ACh
Lindstrom et al 1970s
59
Identified the COLQ gene
Ohno 1998
60
Discovery of Alzheimers
Alzheimer 1902
61
Formally introduced the cholinergic hypothesis of Alzheimer's
Davies and Summers 1976
62
Fist to isolate and characterise amyloid-beta peptide from cerebral plaques of Alzheimer's patients
Glenner and Wong 1984
63
Aducanumab
Nature 2021
64
nAChR selective ligands (multifunctional drug)
Dallanoce and Clelia et al 2012
65
Homozygous mice for tau has 20 hour clock
Spolestra 2016
66
Chronopharmacodynamics of antidepressants
Silva et al 2021
67
Transdermal drug delivery
Bisht 2021
68
First programmable in-time infusion pumps were for diabetes
80s and 90s for cancer in Europe
69
Retinal ganglion cells are sensitive to blue light
Berson 2002
70
Chronotype depending factors
Walch et al 2016
71
2 year survival and quality of life of cancer patients with robust circadian rhythms
Ballesta 2017
72
Danish Nurse Cohort study
Hankinson 2001
73
Opponent Process Model
Rechtschaffen and Kales 1960s
74
Lower amplitudes in elderly
Hood and Amir 2017
75
Ways to establish normalised day-night patterns in Alzheimer's disease
Landry and Liu-Ambrose 2014
76
Circadian disruption is a prinicipal component of Alzheimers disease
Musiek and Holtzman 2016
77
Interpersonal and social rhythm therapy
Dunster et al 2021
78
Effectiveness of Agomelatine in the treatment of depression
Moreno et al 2007
79
Optimal time of antidepressant administration
Silva 2021
80
Body processes have optimums at different times and these correlate with disease
Allada 2021
81
Oubain study
Halberg and Stephens 1959
82
Circadian regulation of BBB
Zhang 2021
83
Three approaches to chronotherapy and its effects in chemo, immuno and radiotherapy
Amiama-Roig 2022
84
Oxaliplatin constant vs circadian administrations
Reinhold 2002
85
Meta-analysis of human GWAS studies on BMI
Willer et al 2009
86
Dog brain stimulation and increase in circulating glucose
Bernard
87
Dual centre theory
Cannon and Washburn 1940s
88
Dual intervention point model
Speakman 2011
89
Parabiosis experiments
Coleman 1970s
90
Hypothalamic short term response to signals
Mayer
91
Glucose static theory
Kennedy
92
Leptin produced in white adipose and is a permissive hormone
Zhang 1994
93
Leptin deficient children
Montague 1997
94
Leptin-induced phospho STAT3
Hosoi 2002
95
Cre-Lox POMC
Balthasar 2004
96
Sf1 positive neurons in VMN
Dhillon 2006
97
DEXA, NEAT is reason for obesity
Levene 1999
98
PET scanning glucose uptake after cold and warm
Virtanen 2009
99
Origins of different fat depots
Kajimura 2010
100
Adipose browning images
Chao et al 2011
101
Central pathways involved in adaptive thermogenesis
Nakamura and Madden 2008
102
DMN PrRP neurons are responsive to leptin STAT3
Dodd 2014
103
KO of leptin receptor in PrRP neurons
Dodd 2014
104
PrRP LepR is required for leptin thermogenesis
Dodd 2014
105
Gpr10 KO mice
Luckman
106
Mutations in the human GPR10 gene
Talbot 2021
107
Ghrelin discovery
Hayashi 1999
108
Time of day ghrelin release
Cummings 2001
109
Fos C used to find AgRP neurons and ghrelin
Dickson and Luckman 1998 and Lawrence 2002
110
AgRP Cre mouse in antiparallel fashion to express channel rhodopsin
Stoneston 2017
111
Optogenetic channel rhodopsin mapping of AgRP
Aponte 2011
112
Optic fibre in AgRP projection after membrane encorporation
Atasoy 2012
113
Downstream targets of AgRP/NPY neurons
Atasoy 2012 and Betley 2013
114
Two ways AgRP neurons project to cause hunger
Stachniac 2014 and Garfield 2015
115
Fibre photometry and finding that ghrelin is to seek food rather than hunger
Chen 2015
116
Ghrelin produces negative valence (CPP)
Schele 2017
117
Closed loop CPP with AgRP
Betley 2015
118
Fatty acid-induced CCK secretion
Mclaughlin et al 1999
119
CCK receptors stained in vagus nerve to the gut
Dockray 2009
120
PrRP expressed in the NTS are activated by CCK
Lawrence 2002
121
LSL-PrRP x Cre mice and CCK response
Dodd 2014
122
DREADDS for PrRP in NTS
Smith 2016
123
PYY acts via Y2 on
NPY to decrease feeding
Scott 2005
124
Behavioural satiety sequency for PYY
Scott 2005
125
2-DG and THC in hedonistic vs homeostatic feeding
Dodd 2010
126
Hemopressin and AM251
Picetti 2017
127
Down regulated dopamine receptor in obese nucleus accumbens
Volkow 2001
128
Leptin deficiency and subjective reward vs supplemented
Farooqi 2007
129
Comparrison of the different bariatric surgeries
Schauer 2004
130
Compared glycaemic control in the gastric bypass
Mingrone 2012
131
Effect of PYY on VAS hunger scores
Batterham 2003
132
PYY attenuates the activation of AgRP/NPY neurons
Jones 2019
133
Effects of NN1273
Jones et al 2019
134
Effects of CCK on feelings of satiety in humans
Gutzwiller 2000
135
CCK analogue NN9056 on minipigs
Christofferson 2020
136
The incretin effect of GLP1
Holst 2007
137
Semaglutide (ozempic) effects
Wilding 2021
138
Effectiveness of Tirzepatide
Frias 2021
139
Caspace virus in GLP1 different areas
Huang 2024
140
Exendin 4 activates Glp1/Gfral/CCK
Costa 2022
141
Disabling CCK neurons through tetanus toxin stops neurotranmitter release and increase in food intake and with
Worth et al 2020
142
GPL1/Gfral/CCK neurons activated by GDF15 projecting to the PBN
Worth 2020
143
CCK PBN activation produced negatve valence in CPP
D'Agostino 2016
144
GIP reduces exendin induced brainstem activation- milkshake study
Costa et al 2022
145
Tirzepatide vs LY343943
Costa 2022
146
Timeline of psychedelic research
Kyzar et al 2017
147
LSD binidng affinities
Nicols 1987
148
5HT2A receptor circuits
Hanks and Gonzalez-Maeso 2013
149
PFC rat brain slice
Cameron 2023
150
HTR to 5HT
Erkiziz-Santamaria 2022
151
Drug discrimination model
Grinspoon and Halpern 1998
152
Dendritic sprouting due to LSD DMT, DOI. Also Inhib of 5HT2A, mTOR and TrKB
Ly et al 2018
153
Molecular mechanisms of neuroplasticity (due to 5HT2A)
Kadriu et al 2021
154
3 levels of functional connectivity due to psychedelics
Nutt 2020
155
Discovery of the default mode network
Raichle 2001
156
Psychedelics disrupt the DMN and increase entropy
Carhart-Harris 2014
157
The thalamic gating model
McCormick 1992
158
ASC
Dittrich 1998
159
M scale
Hood Jr 1975
160
ASC and Clinical outcome at 5 weeks post psychedelic
Roseman, Nutt, Cahart-Harris 2018
161
Psylocibin and drinking/ drinking days
Bogenschutz 2015
162
Decreased alcohol consumption with TBG
Cameron et al 2021
163
Legal drugs causing more harm
Peacock 2018
164
All the addiction cycle bits
Koob 2011
165
Cocaine actions at the synapse
Bravo 2022
166
Cannabis effects at the synapse
Garaj and Xiong 2019
167
Spatial bias for MOP ligands
Bryan and Roth 2010s
168
Self-Admin model of cocaine
Panlilo and Goldberg 2007
169
Combining microdialysis and self administration
Meissner and O'Keefe 1983
170
Translatable models to humans
Nieto 2021
171
Acamprosate and ethanol mouse CPP
McGeehan and Olive 2003
172
acamprosate on the alcohol deprivation effect
Spanagel 2014
173
Naltrexone on the alcohol deprivation effect
Simms et al 2008
174
Drug primed reinstatement and acamprosate
Bachteler 2005
175
Drug primed reinstatement and naltrexone vs extinction
Burratini et al 2006
