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Neuropharmacology > References > Flashcards

References Flashcards

1
Q

The significant contribution of NMDA to E rev at physiological concentrations

A

Jahr and Stevens 1993

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2
Q

AMPA/Kainate receptor tetramers

A

Rosemund 1998

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3
Q

NMDA receptor tetramers

A

Laube 1998

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4
Q

Kainate-Rs dual mode of action

A

Melyan 2002

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5
Q

MGluR structure

A

Conn and Pin 1997

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6
Q

First report of toxic effect of LGlu

A

Lucas and Newhouse 1957

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7
Q

Term excitotoxicity

A

Olney 1971

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8
Q

Acute LGlu Excitotoxicity

A

Rothman 1985

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9
Q

Delayed L-Glu excitotoxicity

A

Choi 1987

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10
Q

Slow excitotoxicity

A

Larm et al 1997

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11
Q

Apoptotic, intermediate hybrid and nectrotic cells

A

Martin 1998

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12
Q

Mg used for epilspsy but not good for stroke

A

Saver 2015, Shkirkova 2017

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13
Q

Blocking NMDARs in 8 day old rat

A

Ikonomidou 1999

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14
Q

Post-natal brain more susceptible to NMDA induced excitotoxicity

A

Zhou and Baudry 2006

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15
Q

Apomorphine reversed reduction in cerebral blood flow associated with hypofrontality

A

Daniel et al 1989

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16
Q

Vervet monkeys given PCP

A

Jentsch et al 1997

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17
Q

GluN1 kockdown mice

A

Mohn et al 1999

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18
Q

Dual agonism of NMDAR by glycine

A

Johnson and Ascher 1987

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19
Q

Injected receptor mRNAs into xenopus oocytes

A

Kutsuwada 1992 and Ishii 1993

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20
Q

HIgh doses of glycine and lower with antipsychotics improve negative symptoms

A

Heresco-Levy 1999 and 2004

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21
Q

D-serine as effective as glycine

A

Tsai et al 1998 and Heresco-Levy 2005

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22
Q

Glycine and clozapine have no improvement perhaps due to occlusion

A

Evins 2000

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23
Q

Sacrosine

A

Tsai 2004

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24
Q

Bitopertin

A

Kingwell 2014

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25
Q

Iclepertin

A

Fleischhacker 2021

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26
Q

Endogenous KYNA mimics actute effects of PCP on the VTA

A

Erhardt and Enberg 2002

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27
Q

40-50% increase of KYNA in CSF of SZC subjects

A

Linderholm 2012

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28
Q

Decreased KYNA levels in rats improved cognitive function

A

Kozak 2014

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29
Q

Humans have lower brain volume etc in depression

A

Kang 2012

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30
Q

Mice have reduced dendritic spines etc in depression

A

Liu and Aghajanian 2008

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31
Q

Humans have decreased AMPA-R GLuA2 and 3 in depression

A

Beneyto 2006

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32
Q

Humans have increased extracellular glutamate in depression

A

Hashimto 2007

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33
Q

Animals have less AMPA and NMDA mediated responses and receptor subunit expression in depression

A

Yuen 2012

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34
Q

Increased inhibition and decrease synaptic LGlu release in mice with depression

A

McKlveen 2016

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35
Q

Decrease LGlu uptake in mice with depression

A

De Vasconcellos-Bittencourt 2011

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36
Q

Increased spine numbers to control after single dose of K

A

Li 2011

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37
Q

More glutamate receptor trafficking and protein synthesis after K

A

Cao 2024

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38
Q

Antidepressent behaviour sustained in FST and LH 2 weeks after K

A

Maeng 2008 and Autry 2011

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39
Q

Mimicked by MK-801 and deletion of GluN2 occludes K effect in FST

A

Maeng 2008, Li 2010, li 2011, Autry 2011 ans Miller 2014

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40
Q

Ketamine action blocked by NBQX in FST

A

Maeng 2008

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41
Q

Increased AMPA trafficking and insertion after K

A

Li 2010, 2011 and Zhang 2016

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42
Q

Increased Phosphorylation of Rapamycin and mTOR activation

A

Li 2010 and 2011

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43
Q

Reduced K effect in trafficking impaired knock in mice for BDNF

A

Liu 2012

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44
Q

Reduced K effect in kock out BDNF mice

A

Autry 2011

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45
Q

Disinhibition ketamine theory

A

Duman group

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46
Q

Direct postsynaptic action ketamine theory

A

Kavalalli group

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47
Q

Associated hypofrontality with negative symptoms of SCZ using PET

A

Weinberger 1986

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48
Q

Who pioneered research into mini ischaemic strokes?

A

Fisher 1962

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49
Q

Discovery of the TCA cycle

A

Krebs 1953

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50
Q

Development of the NMJ

A

Borges and Richman 2020

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51
Q

Demonstrated enzyme activity degrading ACh (AChE)

A

Feldberg and Quastel 1930s

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52
Q

Found that there was another cholinersterase that was not AChE

A

Spiro and Knoop 1925-30s

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53
Q

Discovery of ACh

A

Loewi 1921

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54
Q

Demonstration that ACh is released when the motor nerve is stimulated

A

Dale 1936

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55
Q

Receptors mediating the responses of cells to transmitters

A

Langley

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56
Q

Muscular nicotinic receptor structure

A

Cetin 2020

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57
Q

Various ACh receptor configuration broadly distributed in the brain

A

Taly 2009

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58
Q

Generated anibodies to purified ACh

A

Lindstrom et al 1970s

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59
Q

Identified the COLQ gene

A

Ohno 1998

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60
Q

Discovery of Alzheimers

A

Alzheimer 1902

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61
Q

Formally introduced the cholinergic hypothesis of Alzheimer’s

A

Davies and Summers 1976

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62
Q

Fist to isolate and characterise amyloid-beta peptide from cerebral plaques of Alzheimer’s patients

A

Glenner and Wong 1984

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63
Q

Aducanumab

A

Nature 2021

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64
Q

nAChR selective ligands (multifunctional drug)

A

Dallanoce and Clelia et al 2012

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65
Q

Homozygous mice for tau has 20 hour clock

A

Spolestra 2016

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66
Q

Chronopharmacodynamics of antidepressants

A

Silva et al 2021

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67
Q

Transdermal drug delivery

A

Bisht 2021

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68
Q

First programmable in-time infusion pumps were for diabetes

A

80s and 90s for cancer in Europe

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69
Q

Retinal ganglion cells are sensitive to blue light

A

Berson 2002

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70
Q

Chronotype depending factors

A

Walch et al 2016

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71
Q

2 year survival and quality of life of cancer patients with robust circadian rhythms

A

Ballesta 2017

72
Q

Danish Nurse Cohort study

A

Hankinson 2001

73
Q

Opponent Process Model

A

Rechtschaffen and Kales 1960s

74
Q

Lower amplitudes in elderly

A

Hood and Amir 2017

75
Q

Ways to establish normalised day-night patterns in Alzheimer’s disease

A

Landry and Liu-Ambrose 2014

76
Q

Circadian disruption is a prinicipal component of Alzheimers disease

A

Musiek and Holtzman 2016

77
Q

Interpersonal and social rhythm therapy

A

Dunster et al 2021

78
Q

Effectiveness of Agomelatine in the treatment of depression

A

Moreno et al 2007

79
Q

Optimal time of antidepressant administration

A

Silva 2021

80
Q

Body processes have optimums at different times and these correlate with disease

A

Allada 2021

81
Q

Oubain study

A

Halberg and Stephens 1959

82
Q

Circadian regulation of BBB

A

Zhang 2021

83
Q

Three approaches to chronotherapy and its effects in chemo, immuno and radiotherapy

A

Amiama-Roig 2022

84
Q

Oxaliplatin constant vs circadian administrations

A

Reinhold 2002

85
Q

Meta-analysis of human GWAS studies on BMI

A

Willer et al 2009

86
Q

Dog brain stimulation and increase in circulating glucose

A

Bernard

87
Q

Dual centre theory

A

Cannon and Washburn 1940s

88
Q

Dual intervention point model

A

Speakman 2011

89
Q

Parabiosis experiments

A

Coleman 1970s

90
Q

Hypothalamic short term response to signals

A

Mayer

91
Q

Glucose static theory

A

Kennedy

92
Q

Leptin produced in white adipose and is a permissive hormone

A

Zhang 1994

93
Q

Leptin deficient children

A

Montague 1997

94
Q

Leptin-induced phospho STAT3

A

Hosoi 2002

95
Q

Cre-Lox POMC

A

Balthasar 2004

96
Q

Sf1 positive neurons in VMN

A

Dhillon 2006

97
Q

DEXA, NEAT is reason for obesity

A

Levene 1999

98
Q

PET scanning glucose uptake after cold and warm

A

Virtanen 2009

99
Q

Origins of different fat depots

A

Kajimura 2010

100
Q

Adipose browning images

A

Chao et al 2011

101
Q

Central pathways involved in adaptive thermogenesis

A

Nakamura and Madden 2008

102
Q

DMN PrRP neurons are responsive to leptin STAT3

A

Dodd 2014

103
Q

KO of leptin receptor in PrRP neurons

A

Dodd 2014

104
Q

PrRP LepR is required for leptin thermogenesis

A

Dodd 2014

105
Q

Gpr10 KO mice

A

Luckman

106
Q

Mutations in the human GPR10 gene

A

Talbot 2021

107
Q

Ghrelin discovery

A

Hayashi 1999

108
Q

Time of day ghrelin release

A

Cummings 2001

109
Q

Fos C used to find AgRP neurons and ghrelin

A

Dickson and Luckman 1998 and Lawrence 2002

110
Q

AgRP Cre mouse in antiparallel fashion to express channel rhodopsin

A

Stoneston 2017

111
Q

Optogenetic channel rhodopsin mapping of AgRP

A

Aponte 2011

112
Q

Optic fibre in AgRP projection after membrane encorporation

A

Atasoy 2012

113
Q

Downstream targets of AgRP/NPY neurons

A

Atasoy 2012 and Betley 2013

114
Q

Two ways AgRP neurons project to cause hunger

A

Stachniac 2014 and Garfield 2015

115
Q

Fibre photometry and finding that ghrelin is to seek food rather than hunger

A

Chen 2015

116
Q

Ghrelin produces negative valence (CPP)

A

Schele 2017

117
Q

Closed loop CPP with AgRP

A

Betley 2015

118
Q

Fatty acid-induced CCK secretion

A

Mclaughlin et al 1999

119
Q

CCK receptors stained in vagus nerve to the gut

A

Dockray 2009

120
Q

PrRP expressed in the NTS are activated by CCK

A

Lawrence 2002

121
Q

LSL-PrRP x Cre mice and CCK response

A

Dodd 2014

122
Q

DREADDS for PrRP in NTS

A

Smith 2016

123
Q

PYY acts via Y2 on
NPY to decrease feeding

A

Scott 2005

124
Q

Behavioural satiety sequency for PYY

A

Scott 2005

125
Q

2-DG and THC in hedonistic vs homeostatic feeding

A

Dodd 2010

126
Q

Hemopressin and AM251

A

Picetti 2017

127
Q

Down regulated dopamine receptor in obese nucleus accumbens

A

Volkow 2001

128
Q

Leptin deficiency and subjective reward vs supplemented

A

Farooqi 2007

129
Q

Comparrison of the different bariatric surgeries

A

Schauer 2004

130
Q

Compared glycaemic control in the gastric bypass

A

Mingrone 2012

131
Q

Effect of PYY on VAS hunger scores

A

Batterham 2003

132
Q

PYY attenuates the activation of AgRP/NPY neurons

A

Jones 2019

133
Q

Effects of NN1273

A

Jones et al 2019

134
Q

Effects of CCK on feelings of satiety in humans

A

Gutzwiller 2000

135
Q

CCK analogue NN9056 on minipigs

A

Christofferson 2020

136
Q

The incretin effect of GLP1

A

Holst 2007

137
Q

Semaglutide (ozempic) effects

A

Wilding 2021

138
Q

Effectiveness of Tirzepatide

A

Frias 2021

139
Q

Caspace virus in GLP1 different areas

A

Huang 2024

140
Q

Exendin 4 activates Glp1/Gfral/CCK

A

Costa 2022

141
Q

Disabling CCK neurons through tetanus toxin stops neurotranmitter release and increase in food intake and with

A

Worth et al 2020

142
Q

GPL1/Gfral/CCK neurons activated by GDF15 projecting to the PBN

A

Worth 2020

143
Q

CCK PBN activation produced negatve valence in CPP

A

D’Agostino 2016

144
Q

GIP reduces exendin induced brainstem activation- milkshake study

A

Costa et al 2022

145
Q

Tirzepatide vs LY343943

A

Costa 2022

146
Q

Timeline of psychedelic research

A

Kyzar et al 2017

147
Q

LSD binidng affinities

A

Nicols 1987

148
Q

5HT2A receptor circuits

A

Hanks and Gonzalez-Maeso 2013

149
Q

PFC rat brain slice

A

Cameron 2023

150
Q

HTR to 5HT

A

Erkiziz-Santamaria 2022

151
Q

Drug discrimination model

A

Grinspoon and Halpern 1998

152
Q

Dendritic sprouting due to LSD DMT, DOI. Also Inhib of 5HT2A, mTOR and TrKB

A

Ly et al 2018

153
Q

Molecular mechanisms of neuroplasticity (due to 5HT2A)

A

Kadriu et al 2021

154
Q

3 levels of functional connectivity due to psychedelics

A

Nutt 2020

155
Q

Discovery of the default mode network

A

Raichle 2001

156
Q

Psychedelics disrupt the DMN and increase entropy

A

Carhart-Harris 2014

157
Q

The thalamic gating model

A

McCormick 1992

158
Q

ASC

A

Dittrich 1998

159
Q

M scale

A

Hood Jr 1975

160
Q

ASC and Clinical outcome at 5 weeks post psychedelic

A

Roseman, Nutt, Cahart-Harris 2018

161
Q

Psylocibin and drinking/ drinking days

A

Bogenschutz 2015

162
Q

Decreased alcohol consumption with TBG

A

Cameron et al 2021

163
Q

Legal drugs causing more harm

A

Peacock 2018

164
Q

All the addiction cycle bits

A

Koob 2011

165
Q

Cocaine actions at the synapse

A

Bravo 2022

166
Q

Cannabis effects at the synapse

A

Garaj and Xiong 2019

167
Q

Spatial bias for MOP ligands

A

Bryan and Roth 2010s

168
Q

Self-Admin model of cocaine

A

Panlilo and Goldberg 2007

169
Q

Combining microdialysis and self administration

A

Meissner and O’Keefe 1983

170
Q

Translatable models to humans

A

Nieto 2021

171
Q

Acamprosate and ethanol mouse CPP

A

McGeehan and Olive 2003

172
Q

acamprosate on the alcohol deprivation effect

A

Spanagel 2014

173
Q

Naltrexone on the alcohol deprivation effect

A

Simms et al 2008

174
Q

Drug primed reinstatement and acamprosate

A

Bachteler 2005

175
Q

Drug primed reinstatement and naltrexone vs extinction

A

Burratini et al 2006

Neuropharmacology (7 decks)

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