References Flashcards
The significant contribution of NMDA to E rev at physiological concentrations
Jahr and Stevens 1993
AMPA/Kainate receptor tetramers
Rosemund 1998
NMDA receptor tetramers
Laube 1998
Kainate-Rs dual mode of action
Melyan 2002
MGluR structure
Conn and Pin 1997
First report of toxic effect of LGlu
Lucas and Newhouse 1957
Term excitotoxicity
Olney 1971
Acute LGlu Excitotoxicity
Rothman 1985
Delayed L-Glu excitotoxicity
Choi 1987
Slow excitotoxicity
Larm et al 1997
Apoptotic, intermediate hybrid and nectrotic cells
Martin 1998
Mg used for epilspsy but not good for stroke
Saver 2015, Shkirkova 2017
Blocking NMDARs in 8 day old rat
Ikonomidou 1999
Post-natal brain more susceptible to NMDA induced excitotoxicity
Zhou and Baudry 2006
Apomorphine reversed reduction in cerebral blood flow associated with hypofrontality
Daniel et al 1989
Vervet monkeys given PCP
Jentsch et al 1997
GluN1 kockdown mice
Mohn et al 1999
Dual agonism of NMDAR by glycine
Johnson and Ascher 1987
Injected receptor mRNAs into xenopus oocytes
Kutsuwada 1992 and Ishii 1993
HIgh doses of glycine and lower with antipsychotics improve negative symptoms
Heresco-Levy 1999 and 2004
D-serine as effective as glycine
Tsai et al 1998 and Heresco-Levy 2005
Glycine and clozapine have no improvement perhaps due to occlusion
Evins 2000
Sacrosine
Tsai 2004
Bitopertin
Kingwell 2014
Iclepertin
Fleischhacker 2021
Endogenous KYNA mimics actute effects of PCP on the VTA
Erhardt and Enberg 2002
40-50% increase of KYNA in CSF of SZC subjects
Linderholm 2012
Decreased KYNA levels in rats improved cognitive function
Kozak 2014
Humans have lower brain volume etc in depression
Kang 2012
Mice have reduced dendritic spines etc in depression
Liu and Aghajanian 2008
Humans have decreased AMPA-R GLuA2 and 3 in depression
Beneyto 2006
Humans have increased extracellular glutamate in depression
Hashimto 2007
Animals have less AMPA and NMDA mediated responses and receptor subunit expression in depression
Yuen 2012
Increased inhibition and decrease synaptic LGlu release in mice with depression
McKlveen 2016
Decrease LGlu uptake in mice with depression
De Vasconcellos-Bittencourt 2011
Increased spine numbers to control after single dose of K
Li 2011
More glutamate receptor trafficking and protein synthesis after K
Cao 2024
Antidepressent behaviour sustained in FST and LH 2 weeks after K
Maeng 2008 and Autry 2011
Mimicked by MK-801 and deletion of GluN2 occludes K effect in FST
Maeng 2008, Li 2010, li 2011, Autry 2011 ans Miller 2014
Ketamine action blocked by NBQX in FST
Maeng 2008
Increased AMPA trafficking and insertion after K
Li 2010, 2011 and Zhang 2016
Increased Phosphorylation of Rapamycin and mTOR activation
Li 2010 and 2011
Reduced K effect in trafficking impaired knock in mice for BDNF
Liu 2012
Reduced K effect in kock out BDNF mice
Autry 2011
Disinhibition ketamine theory
Duman group
Direct postsynaptic action ketamine theory
Kavalalli group
Associated hypofrontality with negative symptoms of SCZ using PET
Weinberger 1986
Who pioneered research into mini ischaemic strokes?
Fisher 1962
Discovery of the TCA cycle
Krebs 1953
Development of the NMJ
Borges and Richman 2020
Demonstrated enzyme activity degrading ACh (AChE)
Feldberg and Quastel 1930s
Found that there was another cholinersterase that was not AChE
Spiro and Knoop 1925-30s
Discovery of ACh
Loewi 1921
Demonstration that ACh is released when the motor nerve is stimulated
Dale 1936
Receptors mediating the responses of cells to transmitters
Langley
Muscular nicotinic receptor structure
Cetin 2020
Various ACh receptor configuration broadly distributed in the brain
Taly 2009
Generated anibodies to purified ACh
Lindstrom et al 1970s
Identified the COLQ gene
Ohno 1998
Discovery of Alzheimers
Alzheimer 1902
Formally introduced the cholinergic hypothesis of Alzheimer’s
Davies and Summers 1976
Fist to isolate and characterise amyloid-beta peptide from cerebral plaques of Alzheimer’s patients
Glenner and Wong 1984
Aducanumab
Nature 2021
nAChR selective ligands (multifunctional drug)
Dallanoce and Clelia et al 2012
Homozygous mice for tau has 20 hour clock
Spolestra 2016
Chronopharmacodynamics of antidepressants
Silva et al 2021
Transdermal drug delivery
Bisht 2021
First programmable in-time infusion pumps were for diabetes
80s and 90s for cancer in Europe
Retinal ganglion cells are sensitive to blue light
Berson 2002
Chronotype depending factors
Walch et al 2016
2 year survival and quality of life of cancer patients with robust circadian rhythms
Ballesta 2017
Danish Nurse Cohort study
Hankinson 2001
Opponent Process Model
Rechtschaffen and Kales 1960s
Lower amplitudes in elderly
Hood and Amir 2017
Ways to establish normalised day-night patterns in Alzheimer’s disease
Landry and Liu-Ambrose 2014
Circadian disruption is a prinicipal component of Alzheimers disease
Musiek and Holtzman 2016
Interpersonal and social rhythm therapy
Dunster et al 2021
Effectiveness of Agomelatine in the treatment of depression
Moreno et al 2007
Optimal time of antidepressant administration
Silva 2021
Body processes have optimums at different times and these correlate with disease
Allada 2021
Oubain study
Halberg and Stephens 1959
Circadian regulation of BBB
Zhang 2021
Three approaches to chronotherapy and its effects in chemo, immuno and radiotherapy
Amiama-Roig 2022
Oxaliplatin constant vs circadian administrations
Reinhold 2002
Meta-analysis of human GWAS studies on BMI
Willer et al 2009
Dog brain stimulation and increase in circulating glucose
Bernard
Dual centre theory
Cannon and Washburn 1940s
Dual intervention point model
Speakman 2011
Parabiosis experiments
Coleman 1970s
Hypothalamic short term response to signals
Mayer
Glucose static theory
Kennedy
Leptin produced in white adipose and is a permissive hormone
Zhang 1994
Leptin deficient children
Montague 1997
Leptin-induced phospho STAT3
Hosoi 2002
Cre-Lox POMC
Balthasar 2004
Sf1 positive neurons in VMN
Dhillon 2006
DEXA, NEAT is reason for obesity
Levene 1999
PET scanning glucose uptake after cold and warm
Virtanen 2009
Origins of different fat depots
Kajimura 2010
Adipose browning images
Chao et al 2011
Central pathways involved in adaptive thermogenesis
Nakamura and Madden 2008
DMN PrRP neurons are responsive to leptin STAT3
Dodd 2014
KO of leptin receptor in PrRP neurons
Dodd 2014
PrRP LepR is required for leptin thermogenesis
Dodd 2014
Gpr10 KO mice
Luckman
Mutations in the human GPR10 gene
Talbot 2021
Ghrelin discovery
Hayashi 1999
Time of day ghrelin release
Cummings 2001
Fos C used to find AgRP neurons and ghrelin
Dickson and Luckman 1998 and Lawrence 2002
AgRP Cre mouse in antiparallel fashion to express channel rhodopsin
Stoneston 2017
Optogenetic channel rhodopsin mapping of AgRP
Aponte 2011
Optic fibre in AgRP projection after membrane encorporation
Atasoy 2012
Downstream targets of AgRP/NPY neurons
Atasoy 2012 and Betley 2013
Two ways AgRP neurons project to cause hunger
Stachniac 2014 and Garfield 2015
Fibre photometry and finding that ghrelin is to seek food rather than hunger
Chen 2015
Ghrelin produces negative valence (CPP)
Schele 2017
Closed loop CPP with AgRP
Betley 2015
Fatty acid-induced CCK secretion
Mclaughlin et al 1999
CCK receptors stained in vagus nerve to the gut
Dockray 2009
PrRP expressed in the NTS are activated by CCK
Lawrence 2002
LSL-PrRP x Cre mice and CCK response
Dodd 2014
DREADDS for PrRP in NTS
Smith 2016
PYY acts via Y2 on
NPY to decrease feeding
Scott 2005
Behavioural satiety sequency for PYY
Scott 2005
2-DG and THC in hedonistic vs homeostatic feeding
Dodd 2010
Hemopressin and AM251
Picetti 2017
Down regulated dopamine receptor in obese nucleus accumbens
Volkow 2001
Leptin deficiency and subjective reward vs supplemented
Farooqi 2007
Comparrison of the different bariatric surgeries
Schauer 2004
Compared glycaemic control in the gastric bypass
Mingrone 2012
Effect of PYY on VAS hunger scores
Batterham 2003
PYY attenuates the activation of AgRP/NPY neurons
Jones 2019
Effects of NN1273
Jones et al 2019
Effects of CCK on feelings of satiety in humans
Gutzwiller 2000
CCK analogue NN9056 on minipigs
Christofferson 2020
The incretin effect of GLP1
Holst 2007
Semaglutide (ozempic) effects
Wilding 2021
Effectiveness of Tirzepatide
Frias 2021
Caspace virus in GLP1 different areas
Huang 2024
Exendin 4 activates Glp1/Gfral/CCK
Costa 2022
Disabling CCK neurons through tetanus toxin stops neurotranmitter release and increase in food intake and with
Worth et al 2020
GPL1/Gfral/CCK neurons activated by GDF15 projecting to the PBN
Worth 2020
CCK PBN activation produced negatve valence in CPP
D’Agostino 2016
GIP reduces exendin induced brainstem activation- milkshake study
Costa et al 2022
Tirzepatide vs LY343943
Costa 2022
Timeline of psychedelic research
Kyzar et al 2017
LSD binidng affinities
Nicols 1987
5HT2A receptor circuits
Hanks and Gonzalez-Maeso 2013
PFC rat brain slice
Cameron 2023
HTR to 5HT
Erkiziz-Santamaria 2022
Drug discrimination model
Grinspoon and Halpern 1998
Dendritic sprouting due to LSD DMT, DOI. Also Inhib of 5HT2A, mTOR and TrKB
Ly et al 2018
Molecular mechanisms of neuroplasticity (due to 5HT2A)
Kadriu et al 2021
3 levels of functional connectivity due to psychedelics
Nutt 2020
Discovery of the default mode network
Raichle 2001
Psychedelics disrupt the DMN and increase entropy
Carhart-Harris 2014
The thalamic gating model
McCormick 1992
ASC
Dittrich 1998
M scale
Hood Jr 1975
ASC and Clinical outcome at 5 weeks post psychedelic
Roseman, Nutt, Cahart-Harris 2018
Psylocibin and drinking/ drinking days
Bogenschutz 2015
Decreased alcohol consumption with TBG
Cameron et al 2021
Legal drugs causing more harm
Peacock 2018
All the addiction cycle bits
Koob 2011
Cocaine actions at the synapse
Bravo 2022
Cannabis effects at the synapse
Garaj and Xiong 2019
Spatial bias for MOP ligands
Bryan and Roth 2010s
Self-Admin model of cocaine
Panlilo and Goldberg 2007
Combining microdialysis and self administration
Meissner and O’Keefe 1983
Translatable models to humans
Nieto 2021
Acamprosate and ethanol mouse CPP
McGeehan and Olive 2003
acamprosate on the alcohol deprivation effect
Spanagel 2014
Naltrexone on the alcohol deprivation effect
Simms et al 2008
Drug primed reinstatement and acamprosate
Bachteler 2005
Drug primed reinstatement and naltrexone vs extinction
Burratini et al 2006
