Red Eye Flashcards

1
Q

What is the most common cause of red eye?

A

Red eye is a common presentation in primary care and is a sign of inflammation.

Most cases will be due to relatively benign problems. The most common cause of red eye presenting in a primary care setting is conjunctivitis.
A small proportion of cases are serious and need urgent treatment.

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2
Q

What are the common causes of red eye?

A
Conjunctivitis 
Blepharitis 
Glaucoma 
Uveitis 
Iritis 
Scleritis 
Episcleritis 
Corneal abrasion
Foreign body 
Keratitis 
Chemical burn
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3
Q

What do you ask in the hx of a px presenting with red eye?

A

History:

  • Time and speed of onset
  • Ocular symptoms (e.g. pain, photophobia, blurred vision, discharge)
  • Systemic symptoms (headaches, nausea and rash on the forehead)
  • Symptoms affecting the other eye
  • Specifically enquire about trauma, however minor it appears to have been
  • Recent contact with infectious illness (herpes simplex, conjunctivitis)

Past ocular hx:

  • Any other episodes
  • Ophthalmic surgery
  • Lazy eye
  • Contact lenses
  • Using any eye drops

General health issues

  • Systemic medication
  • Any recent changes to medications
  • Allergies

Social hx:

  • Determine whether the eye condition is affecting activities of daily living.
  • Establish whether there is an immediate management problem
  • Ask whether the patient drove to the surgery. Establish whether they are fit to drive away again.
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4
Q

What do you examine in a px presenting with a red eye?

A

Essential to record the VA in both eyes
If no ocular causes emerge, consider potential systemic causes.
Scleritis and episcleritis are associated with connective tissue diseases such as RA, gout, syphilis, sarcoidosis and HTN.

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5
Q

What are the causes of acute painful red eye?

A
Acute angle-closure glaucoma 
Keratitis 
Acute anterior uveitis 
Trauma- foreign body or corneal abrasion
Endophthalmitis 
Scleritis
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6
Q

What are the causes of acute non-painful red eye?

A

Conjunctivitis
Episcleritis
Subconjunctival haemorrhage

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7
Q

What are the causes of non-acute red eye?

A
Acne rosacea 
Canaliculitis 
Blepharitis 
Lagophthalmos
Floppy eyelid syndrome 
Trichiasis 
Inflamed Pinguecula
Stevens-Johnson syndrome
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8
Q

What is inflamed pinguecula?

A

A pingueculum is a common, innocuous lesion seen as a cluster of yellow-white deposits (usually in a triangular formation with the base adjacent to the cornea), arranged temporally or nasally to the cornea.

It results from degenerative change in the sclera from environmental irritants, including sunlight.

If it becomes inflamed (pingueculitis), it becomes red and may be elevated, sore or ulcerated.

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9
Q

What is the management of a red eye?

A

Urgent referral for potentially serious problems.

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10
Q

Which features are suggestive of a serious condition which may warrant urgent referral in a px of red eye?

A

Moderate-to-severe eye pain or photophobia.
Marked unilateral redness. The greater the redness, the more likely it is that the cause is serious.
Ciliary injection, which is not always obvious, is suggestive of inflammation of deeper structures. It is indicated by redness and dilated blood vessels that can be seen between the sclera and the iris.
Reduced VA.
Photophobia or seeing coloured haloes around point sources of light.
Copious purulent discharge (particularly in neonates).
Corneal involvement.
Known or suspected eye trauma.
Recent ocular surgery.
Pupillary distortion or abnormal reaction.
Herpes simplex or herpes zoster.
Recurrent episodes.
Proptosis.
Contact lens wear.

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11
Q

What is conjunctivitis?

A

This is the inflammation of the conjunctiva.

Associated corneal involvement give rise to keratoconjunctivitis.

Eyelid involvement suggests blepharoconjunctivitis.

It can be classified as infectious or non-infectious, and as acute, chronic, or recurrent.

It can affect any age group. There is no gender, ethnic or social preponderance.

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12
Q

What is the presentation of conjunctivitis?

A

Red eye, which is usually generalised, often bilateral.

Irritation, grittiness and discomfort are typical; significant pain suggests alternative diagnoses.

Discharge, which may be watery, mucoid, stickly or purulent.

Photophobia is not typical.

VA should be unaltered.

Signs include:
Conjunctival chemosis
Conjunctival injection with dilated conjunctival vessels
Follicles or papillae
Corneal involvement (this occurs rarely): oedema, neovascularisation and punctate epithelial erosions.

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13
Q

What are follicles?

A

Follicles are round collections of lymphocytes, most prominent in the inferior fornix, which appear as small, dome-shaped nodules, pale at the top and without prominent central vessels, although blood vessels may overlie them.

They are typically seen in conjunctivitis caused by viruses, atypical bacteria and toxins, including some topical medications (especially brimonidine).

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14
Q

What is a papillae?

A

Papillae have a cobblestone appearance of flattened nodules with central vascular cores, appearing red on the surface and pale at the base.

They are most commonly associated with an allergic immune response, as in vernal and atopic keratoconjunctivitis, or as a response to a foreign body such as a contact lens. Papillae coat the tarsal surface of the upper eyelid and may reach large size (giant papillary conjunctivitis).

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15
Q

How do you assess conjunctivitis?

A

Ask about:

  • Recent upper respiratory tract illness.
  • Recent infectious contacts, particularly to other cases of conjunctivitis.
  • Morning discharge and stickiness, as the patient is likely to have cleaned this away.
  • Spectacle or contact lens wear (and lens hygiene).
  • Chemical exposure (including occupational exposure).
  • Medication.
  • Ultraviolet light exposure (including sunlamps and welding lamps).
  • Any history of foreign body or eye trauma.
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16
Q

What do you do in the exam for conjunctivitis?

A

Exam:

  • Wear gloves if suspecting adenoviral infection - this is extremely contagious (clean all equipment after use).
  • Look for evidence of generalised malaise and preauricular lymph nodes.
  • Check visual acuity.
  • External eye: assess for evidence of orbital cellulitis, blepharitis, herpetic rash or nasolacrimal blockage.
  • Conjunctiva: look at the pattern of congestion, discharge and for the presence of follicles or papillae.
  • Papillae
  • Follicles
  • Cornea: note whether there is evidence of corneal involvement. Staining is an essential part of the examination.
  • Fundoscopy: this is necessary if you are unsure about the diagnosis. Look for clouding of the anterior chamber.
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17
Q

What are the investigations of conjunctivitis?

A

Generally, the diagnosis is rapidly made following history and examination but further investigations are warranted (referral to a specialist) in the following circumstances:

  • Severe purulent discharge.
  • Follicular conjunctivitis.
  • Neonatal conjunctivitis.
  • Unclear aetiology.
  • Non-response to conventional treatment.
18
Q

What are the differentials of conjunctivitis?

A
Uveitis 
Glaucoma 
Herpes zoster ophthalmicus 
Keratitis 
Scleritis and episcleritis 
Foreign body 
Trauma
19
Q

What are the classification of conjunctivitis?

A
Viral 
Bacterial 
Allergic 
Chronic 
Cicatricial 
Giant papillary 
Parinaud’s oculoglandular syndrome 
Pediculosis
20
Q

What are the causes of viral conjunctivitis?

A

Adenovirus
HSV
Herpes zoster ophthalmicus (HZV)
Molluscum contagiosum

21
Q

What are the causes of bacterial conjunctivitis?

A

Bacterial conjunctivitis- most commonly caused by staphylococcus spp. Streptococcus pneumoniae, H. influenzae and Moraxella catarrhalis.
Hyperacute conjunctivitis
Chlamydial conjunctivitis
Conjunctivitis is sometimes seen in Lyme disease, although it more often leads to additional, deeper eye inflammation.

22
Q

What is chronic conjunctivitis?

A

Most bacterial and viral infections resolve spontaneously within two weeks.

Chlamydial infections and some bacterial infections can cause chronic conjunctivitis lasting for weeks or months if untreated.

Causes of chronic conjunctivitis include:

  • Persistent/recurrent infective conjunctivitis.
  • Chlamydia/trachoma.
  • Molluscum contagiosum.
  • Toxic reaction.
  • Superior limbic keratoconjunctivitis.
  • Blepharitis.

Follicles present:
-With preauricular lymph nodes
Suggests toxic conjunctivitis, molluscum, pediculosis.
-Without preauricular lymph nodes
-With herpetic signs: suggests HSV conjunctivitis.
-Without herpetic signs: suggests adenoviral conjunctivitis or chlamydia.

Papillae present:

  • Severe purulent discharge, eyelid swelling: gonococcal infection.
  • Scant purulent discharge: bacterial other than gonococcus.
  • Watery discharge: allergic, atopic.
  • Mucoid discharge: consider vernal conjunctivitis.
23
Q

What is cicatricial conjunctivitis?

A

This refers to a group of inflammatory conditions affecting the conjunctiva.

They lead to scarring (the term cicatricial means scarring), loss of function and, potentially, loss of sight.

All should be referred urgently for ophthalmological review.
Causes:
-Ocular mucous membrane pemphigoid
-Erythema multiforme, Stevens-Johnson syndrome, TENS

Secondary causes:

  • Trauma
  • Chronic and severe anterior blepharitis: the reduction in the tear film associated with blepharitis can cause chronic irritation and scarring.
  • Drugs may cause mild-to-severe irritation.
  • Inherited conditions
  • Systemic problems: many inflammatory and autoimmune conditions can cause cicatricial conjunctivitis.
  • Neoplasia: unilateral conjunctival disease can rarely, represent sebaceous cell carcinoma.
24
Q

What is infective conjunctivitis?

A

Bacterial conjunctivitis is usually a benign self-limiting illness.

However, it can sometimes be serious or signify a severe underlying systemic disease. Occasionally, significant ocular and systemic morbidity may result.

Viral conjunctivitis can be prolonged and can, in some cases, have lasting consequences.

Adenoviral infection is usually (but not always) mild and self-limiting, whereas herpes viruses can cause significant associated keratitis and uveitis.

25
Q

How can you determine the cause of conjunctivitis?

A

A history of infectious conjunctivitis and of itch both make current bacterial involvement less likely, as itch suggests allergic cause and recurrence suggests viral conjunctivitis.

The absence of itch and the absence of a positive history of infective conjunctivitis make a diagnosis of bacterial conjunctivitis more probable.

A purulent, sticky discharge suggests bacterial infection.
Watery discharge is more suggestive of viral or allergic conjunctivitis.
Preauricular lymph nodes are suggestive of viral conjunctivitis.

Eyelids that are stuck together in the morning do not necessarily indicate the presence of a purulent discharge.
Viral conjunctivitis and allergic conjunctivitis often cause lids to be matted shut on waking, due to drying of tears and serous secretions.

26
Q

What are the symptoms of bacterial conjunctivitis?

A

Discomfort - burning or gritty but not sharp.
Significant pain suggests a more serious diagnosis.
Vision is usually normal, although ‘smearing’, particularly on waking, is common.
Discharge tends to be thick rather than watery.
There may be mild photophobia. Significant photophobia suggests severe adenoviral conjunctivitis or corneal inflammation.

27
Q

What are the findings of bacterial conjunctivitis?

A

Red eye, with uniform engorgement of all conjunctival blood vessels.

Typically causes a yellow-white mucopurulent discharge.

Eyes may be difficult to open in the morning, with lids glued together by discharge.

Bacterial conjunctivitis is usually bilateral (though often sequential).

Visual acuity should be normal, other than the mild and temporary blur secondary to the discharge.

There may be a conjunctival follicles, which are round collections of lymphocytes, most prominent in the inferior fornix, appearing as small, dome-shaped nodules, pale at the top and red at the base.

28
Q

What are the types of bacterial conjunctivitis?

A

Simple bacterial conjunctivitis

Gonococcal conjunctivitis

Chylamydial infection

Ophthalmia neonatorum

29
Q

What is simple bacterial conjunctivitis?

A

Causes include S.aureus, s. epidermidis and s.pneumoniae.

Risk factors in children include nasolacrimal duct obstruction, concomitant otitis media or pharyngitis, and exposure to an affected individual.

In adults, additional risk factors include lid malposition, severe tear deficiency, immunosuppression and trauma.

30
Q

What is gonococcal conjunctivitis?

A

Causative organism is Neisseria gonorrhoeae.

Risk factors include contact with infected individuals, and the presence of other STIs.

Patients should be offered screening for other STIs, including chlamydia. Sexual partners should also be traced and treated as appropriate, which will usually necessitate a referral to local sexual health services

31
Q

What is ophthalmia neonatorum?

A

Ophthalmia neonatorum is any conjunctivitis within the first 28 days of life. May be chemically induced or arise as a result of infection through contamination from the maternal genital tract.

32
Q

What is the management of bacterial conjunctivitis?

A

Most cases are self-limiting and management is supportive.

Conjunctivitis caused by gonococcal or chlamydial infection should be treated with antibiotics.

Advice to patients

Many cases of conjunctivitis seen in primary care are viral. These cases will not benefit from the use of antibiotics.

NICE suggests offering a topical ocular antibiotic to a person with infective conjunctivitis when the condition is severe, or likely to become severe, providing serious causes of a red eye can be confidently excluded.

Chloramphenicol is the drug of choice for superficial eye infections. It is bacteriostatic, with a relatively broad spectrum of action against most Gram-positive and Gram-negative bacteria.

Fusidic acid is useful for staphylococcal infections and is an alternative antibacterial agent to chloramphenicol.

33
Q

What is the advice to patients with conjunctivitis?

A

Infective conjunctivitis is a self-limiting illness that usually settles without treatment within 1-2 weeks. If symptoms persist for longer than two weeks they should return for review.

Seek medical attention urgently if marked eye pain or photophobia, loss of visual acuity, or marked redness of the eye develop.

Remove contact lenses, if worn, until all symptoms and signs of infection have completely resolved and any treatment has been completed for 24 hours.

Lubricant eye drops may reduce eye discomfort; these are available over the counter, as well as on prescription.

Clean away infected secretions from eyelids and lashes with cotton wool soaked in water.

Wash hands regularly, particularly after touching the eyes.

Avoid sharing pillows and towels.

It is not necessary to exclude a child from school or childcare if they have infective conjunctivitis, as mild
infectious illnesses should not interrupt school attendance. An exception would be if there is an outbreak of infective conjunctivitis, when advice should be sought from the Health Protection Agency by the school.

Adults who work in close contact with others, or with vulnerable patients, should avoid such contact until the discharge has settled.

34
Q

When is chloramphenicol contraindicated?

A

It should be avoided in people who have experienced myelosuppression during previous exposure to chloramphenicol, in those who have a blood dyscrasia or who have a family history of blood dyscrasias and in patients who are concurrently with other myelotoxic drugs.

It should be avoided in pregnant or breast-feeding women, as its safety has not been established.

Prolonged use should be avoided, since this may increase the likelihood of sensitisation and resistance.

35
Q

What are the complications of bacterial conjunctivitis?

A

Corneal ulceration
Blepharitis
Otitis media

36
Q

What is adenoviral conjunctivitis?

A

Adenoviral conjunctivitis accounts for 65-90% of viral conjunctivitis.

This is a highly infectious condition (incubation: 3-29 days, infectious for a further two weeks) which can range from mild to severe.

Causes follicular conjunctivitis but there are two presentation: Pharyngoconjunctival fever and epidemic keratoconjunctivitis (more severe)

37
Q

What are the symptoms of viral conjunctivitis?

A

Symptoms usually begin in one eye, becoming bilateral after a few days.

There is commonly a history of upper respiratory tract infection or of close contact with someone with a red eye.

There is a burning or gritty foreign body sensation.

Patients notice morning crusting.

Discharge is watery and mucoid rather than purulent and sticky.

38
Q

What are the signs of viral conjunctivitis?

A

The conjunctiva is typically very red and irritated.

There may be pinpoint conjunctival haemorrhages.

Eyelid redness and oedema are common.

Preauricular lymphadenopathy is a classic sign.

Follicles are typically seen, particularly on the inferior palpebral conjunctiva.

Corneal involvement is seen in epidemic keratoconjunctivitis but usually not in pharyngoconjunctival fever.

39
Q

What is the management of viral conjunctivitis?

A

Management is essentially supportive.

Cool compresses and artificial tears used several times daily may improve comfort.

Viral conjunctivitis can last 4-6 weeks and can get worse before it gets better.

Contact lenses should not be worn until all symptoms and signs of infection have completely resolved and any treatment has been discontinued for 24 hours.

Lubricant eye drops may reduce eye discomfort; these are available over the counter, as well as on prescription.

40
Q

What is HSV conjunctivitis?

A

Ocular herpes simplex requires urgent referral to ophthalmology for exclusion of uveitis..
Topical antiviral treatment, such as aciclovir, is the usual treatment.
Contact lens wear should be discontinued until symptoms have settled and treatment is complete.
If the keratitis extends deep into the stroma, topical steroids may be used under specialised supervision to prevent scarring.
Some patients with recurrent HSV keratitis are kept on long-term prophylactic oral antivirals