Red Blood Cells Flashcards

1
Q

Which cells are erythrocytes, leukocytes and platelets derived from?

A

(pluripotent) haemopoietic stem cells (HSCs)

HSCs give rise to lymphoid stem cells and myeloid stem cells, from which erythrocytes, granulocytes, monocytes and platelets are derived

(and they are produced through life in the bone marrow)

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2
Q

What is haemopoiesis?

A

the formation and development of blood cells

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3
Q

What is the approximate intravascular life span of an erythrocyte?

A

120 days

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4
Q

What is the approximate intravascular life span of a neutrophil?

A

7-10hrs

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5
Q

What is the approximate intravascular life span of a monocyte?

A

several days

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6
Q

What is the approximate intravascular life span of an eosinophil?

A

a little shorter than neutrophil (7-10hrs)

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7
Q

What is the approximate intravascular life span of a lymphocyte?

A

varies

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8
Q

What is the approximate intravascular life span of a platelet?

A

10 days

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9
Q

What is the major function of erythrocytes?

A

oxygen transport

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10
Q

What is the major function of neutrophils?

A

defence against infection by phagocytosis and killing of microorganisms

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11
Q

What is the major function of monocytes?

A

defence against infection by phagocytosis and killing of microorganisms

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12
Q

What is the major function of eosinophils?

A

defence against parasitic infection

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13
Q

What is the major function of lymphocytes?

A

humoral and cellular immunity

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14
Q

What is the major function of platelets?

A

haemostasis

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15
Q

How many blood cells does the average person produce each day?

A

500 billion

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16
Q

What are the two essential characteristics of HSCs?

A

self renew

  • some daughter cells remain as HSCs
  • pool of HSCs not depleted

differentiate to mature progeny
- other daughter cells follow a differentiation pathway

(see diagram 5/11 of haemopoiesis pptx)