Red blood cells Flashcards
1
Q
When does Hb F peak? How much HbF at birth?
A
3rd trimester (90% at 24 wks) 70% at birth.
2
Q
When do children have normal amounts of HbA?
A
6-12 months
3
Q
How much HbA2 at birth and 6-12 months?
A
Birth - <1%
12 months 2-3.4%
4
Q
What are causes of elevated HbF?
A
Age Beta thalassaemia trait Homozygous thalassaemia Congenital HbF HbSS or Hb SC Preterm (treated with EPO Haematological stress ie. haemolytic anemia, leukemia, aplastic anaemia
5
Q
When do you get elevated HbA2
A
> 3.4% in betathalassaemia and VitB12/folate deficiency.
6
Q
How long do neonatal RBC live for?
A
60-90 days
7
Q
When do you get low HbA2
A
Fe deficiency and alpha thalassaemia.
8
Q
What is the inheritance of heridatory spherocytosis?
A
AD. 25% AR.
