Red Blood Cell Disorders Flashcards
Absorption of iron occurs in the
Duodenum
takes both heme and non-heme iron into erythrocyte from intestinal lumen
DMT1
transports iron across cell membrane of erythrocytes into blood
Ferroportin
transports iron in blood and delivers to bone marrow and liver MQs for storage
transferrin
stored intracellular iron is bound to
Ferritin (prevents Fenton reaction)
Fenton reaction
how iron forms free radicals
measure of transferrin molecules in the bood
TIBC
%transferrin molecules bound by iron
% saturation (normal is 33%)
Solely breast fed infant
Iron deficiency b/c human milk is low in iron
Pregnancy
iron deficiency because need alot of iron to grow fetus
PUD males
iron deficiency
Ancylostoma duodenale and Necator americanus
hookworms; cause of iron deficiency in developing worlds
gastrectomy
iron deficiency because acid aids iron absorption by maintaining Fe2+ state, which is more readily absorbed than Fe3+.
decreased ferritin, increased TIBC
storage iron depleted
stages or iron deficiency
depletion of stored iron->depletion of serum iron->normocytic anemia->microcytic, hypochromic anemia
anemia, koilonychia, pica
iron deficiency clinical features
measures the spectrum of size of RBCs
red cell distribution width (if all cells similar size, then would be low; normal). increased in microcytic hypochromic anemia.
Fe+protoporphyrin
=Heme
FEP (free erythrocyte protoporphyrin)
increased in iron deficiency anemia
anemia, dysphagia, beefy red tounge
Plummer-vinson syndrome; iron deficiency anemia with esophageal web and glossitis
Hepcidin
acute phase reactant produced by liver in chronic disease
increased ferritin, decreased TIBC, decreased serum iron, decreased %saturation, increased FEP
Anemia of Chronic Disease
anemia due to defective protoporphyrin synthesis
sideroblastic anemia
converts succinyl CoA to aminolevulinic acid (ALA)
Aminolevulinic acid synthetase (ALAS)+B6 (cofactor)
