Red Blood Cell Components Flashcards
Which two filtration systems exist to process RBC products?
Whole blood filtration and buffy coat production
What anticoagulant is used for RBC products?
Citrate phosphate dextrose
What additive is used for RBC products?
SAGM (saline, adenine, glucose, mannitol)
What is the key feature of a closed system in terms of transfusion?
That contents of whole blood are moved between bags without exposure to air
What is the shelf life of the original closed system SAGM blood bag?
42 days stored at 1-6 degrees
What is the average volume of a blood bag?
287 +/- 20 mL
What happens to the shelf life of a blood bag if you enter or breach it?
There’s an increased risk of bacterial contamination, so the expiry date gets adjusted. You have to use it within 24 hours if stored at 1-6 degrees or within 4 hours if stored above 6 degrees. The transfusion into a patient through an infuser must be done within 4 hours.
How do you spike a blood bag?
You peel back the covers to open the port, push the secondary bag spike into the port, twist and push until the spike is firmly in place and has punctured the inner seal. Make sure you do this aseptically and in the fume hood
What is donor blood tested for?
Antibodies to HIV-1, HIV-2, HCV, HTLV, and HBcore
HBsAg
Viral RNA HIV-1 and HCV
DNA HBV
Syphilis
WNV and chagas if at risk donors
CMV (sometimes)
If a packed cell unit is issued but not used can it be returned?
Yes, if within 60 minutes or within 3 hours if issued in a cooler
How is hypovolemia without significant red cell mass deficit best managed?
Colloid solutions such as albumin, 10% pentastarch, and crystalloid solutions
How should anemias be primarily treated?
Appropriate specific non-blood derived therapy (e.g., iron, vitamin B12, folic acid, and recombinant erythropoietin)
