Recurrent pregnancy loss Flashcards
What % of couples are affected by RPL?
1%
What is the % risk of 1st trimester miscarriage in a woman with AMA?
15-93%
What is the % risk of 1st trimester miscarriage in a woman with three previous consecutive pregnancy losses?
40%
What % of woman with RPL is attributable to antiphospholipid syndrome?
15%
For women with antiphospholipid syndrome, by what % does aspirin and clexane reduce their risk of miscarriage?
54%
For women with recurrent 2nd trimester pregnancy loss due to cervical incompetence, cervical cerclage reduces their risk of pregnancy loss by what %?
60%
In a woman with unexplained RPL, what % chance does she have of a live term pregnancy?
75%
RPL and SPIN study:
What was the hypothesis of this study?
Treatment with enoxaparin and LDA along with intensive pregnancy surveillance reduces rate of pregnancy loss compared with intensive pregnancy surveillance alone in women with history of 2 or more consecutive previous pregnancy losses.
RPL and SPIN study:
What were the conclusions of this trial?
What was a major weakness of this trial?
No reduction in pregnancy loss rate with antithrombotic intervention in pregnant women with 2 or more consecutive previous pregnancy losses.
Weakness: different definition of RPL (2 x rather than >=3 x recurrent losses) so findings may not be applicable to RPL population.
RPL and Kaandrop trial:
What was the hypothesis of this study?
Aspirin or aspirin + heparin in early pregnancy improves the rate of live births in women by with unexplained recurrent miscarriage
RPL and Kaandrop study:
What were the conclusions of this trial?
What was a major weakness of this trial?
Conclusions:
Neither aspirin or combination therapy improved the live birth rate compared with placebo.
Weakness: Definition of recurrent miscarriage was only two miscarriages (and doesn’t clarify if consecutive miscarriages either)
