Receptors and Pharmacological Management Flashcards
Adrenergic receptors
Released by postganglionic sympathetic neurons.
Beta 1, Beta 2, Alpha 1, Alpha 2, Neurotransmitters
Beta 1 receptors
On heart and fat cells
^ HR, ^ force of contraction, ^ lipolysis
Beta 2 receptors
On smooth muscle and ducts
Relax smooth muscle, potassium uptake in S.M., glycogenolysis activation in liver
Alpha 1 receptors
On target organs (blood vessels)
Contract smooth muscle
^ Force of contraction of heart
Alpha 2 receptors
On target organs
presynaptic inhibition of norepinephrine release (postsynaptic membrane)
Inhibit lipolysis, contract some vascular smooth muscle
Norepinephrine
(Neurotransmitter)
Released from postsynaptic neuron and adrenal medulla
Acts on alpha receptors
Epinephrine
(Neurotransmitter)
Released from adrenal medulla
Acts on alpha and beta receptors
Cholinergic receptors
Nicotinic receptors, Muscarinic receptors
Nicotinic receptors
Postganglionic neuron transmission (SNS and PNS), S.M. contraction
Muscarinic receptors
Decrease HR (SA, AV, atria)
Anti-anginal drugs
Decrease O2 demand: Beta blockers Nitrates ^ O2 supply: Calcium channel blockers Thrombolytics Antiplatelets Anticoagulants
Heart failure drugs
Diuretics Positive inotropes... Angiotensin converting inhibitors Vasodilators Beta blockers (Carvedilol, Metropolol) Morphine...
Antiarrhythmics
Class I (Sodium channel blockers) Class II (Beta blockers) Class III (Prolong repolarization) Class IV (Calcium channel blockers) Digitalis
Antihypertensives
Diuretics (decrease volume)
Nonadrenergics (directly dilates arteries)
Alpha adrenregic blockers (prevent NE from binding)
Centrally acting agents (inhibit CNS sympathetic output)
ACE inhibitors
Beta blockers
Calcium channel blockers
Angiotensin II receptor blockers
Vasopressors
(Used to ^ HR and BP post op in ICU) Isopeterenol (Isuprel) Dopamine Dobutamine Epinephrine Norepinephrine (Levofed)
