Receptors and Basic Pharmacology - Part 2

Question 1

What is EC50?

Answer 1

The dose needed to produce 1/2 the drug’s maximum effect

Question 2

T/F - A drug’s maximum effect is observed when the drug concentration greatly exceeds the EC50

Answer 2

True - There is a maximum pharmacological effect and once the drug concentration reaches a certain level, adding more wont add effect

Question 3

If the drug concentration is equal to the EC50 value, what happens?

Answer 3

1/2 the physiological effect of the drug occurs

Question 4

Is EC50 the same as Kd?

Answer 4

No
1/2 the maximum effect is often less than 1/2 the maximum binding
(Ec50

Question 5

What is the dose response curve?

Answer 5

S-shaped graph showing the effect on an organism caused by differing doses/concentrations of a drug

Question 6

Partial agonist

Answer 6

An agonist that is poor at activation, and it’s best can’t achieve the same as the best of other agonists
(Higher Kd)

Question 7

Drug efficacy

Answer 7

The maximum effect a drug can produce regardless of dose

Question 8

Drug potency

Answer 8

The amount of drug required to produce a given effect

Question 9

What factor determines the concentration dependence of drug action

Answer 9

Binding affinity

Question 10

What are the different receptor gene families?

Answer 10

a and B

Question 11

Why are the receptor gene families important in understanding pharmacology?

Answer 11

They explain the need for receptor specific agonists and antagonists
And it explains the complexity of drug activation