Receptors

Question 1

What are the 3 main types of receptors?

Answer 1

Nuclear receptors - interact with DNA, steroid, oestrogen, retonoic acid receptors. Affect gene expression. Zinc fingers, dimerisation domain.

Intracellular receptor; on SR, ER…ryanodine receptor activated by Ca++ and other modulators
IP3 receptor
Some ligand gated ion channels

Plasma membrane receptors

• Ligand gated ion channels
• GPCRs
• Intrinsic enzyme receptors

Question 2

Ligand gated ion channel families - 3 subgroups and examples and structure and consequence of activation.

Answer 2

1)Nicotinic ACh Receptor Like
nAChR, 5HT3, GABAa, glycine
Pentameric, 4TMD, extracellular N and C termius
2)ATP Receptor Like
P2x1-7
3 subunits, 2TMDs, intracellular N and C terminus
3)Ionotropic Glutamate like -
NMDA, AMPA, Kainate
4 subunits, 3 TMD with an inverted P loop, extracellular N and intracellular C.

Question 3

GPCRs - 3 subgroups and examples and structure and consequence of activation.

Answer 3

1)Rhodposin like
mACH, opiod, NAdr, cannabinoid, DA, NPY, 5HT1245
2)Metabotropic Glu Receptor
mGlu1-8, GABAb
3)Secretin receptor like
V1, parathyroid hormone

7TMD

Question 4

the brain is a complex organ…. Let me explain #science

the brain works in only two ways, good ways and bad ways. Let me explain #revision

Answer 4

by George White

Question 5

Intrinsic enzyme receptors - 2 subgroups and examples and structure and consequence of activation.

Answer 5

1) Receptor tyrosine kinase - NGF (TrkA), insulin
2) Receptor gunaylyl cyclase (ANP receptor)

Ligand binding
2 agonists for dimerisation
Autophosphorylation
Substrate phosphorylation (ion channel, receptor, 2nd messenger)