Receptors 4

Question 1

What is the Lock and Key model

Answer 1

the interaction of the a drug (ligand) with a receptor (protein) is sometimes described as analogous to a lock and key fit in which the drug is complementary to the receptor.

Question 2

In a lock and key model the drug and receptor are described as what?

Answer 2

rigid

Question 3

does the lock and key model have high specificity?

Answer 3

yes it does have high specificity.

Question 4

What is the induced fit model?

Answer 4

this hypothesis has been described as “a hand in a glove”, where the hand and the glove both adjust their shapes to provide an optimal fit. The protein receptor changes conformation on binding to its ligand (drug)

Question 5

What is the conformational -selection model?

Answer 5

this model suggest the protein receptor fluctuates among several conformational states. Only some of these conformational states allow binding to its ligand

Question 6

What are some drug targets?

Answer 6

proteins -receptors -enzymes -binding sites nonprotein -DNA

Question 7

What is pharmacophore?

Answer 7

minimum chemical features necessary to elicit the biological response at a given biological target

Question 8

Pharmacodynamics

Answer 8

the study of the effects of drugs on the body. This includes the interactions of drugs with their biological targets