Receptors Flashcards
1
Q
What are the 3 essential functions of ion channels?
A
- Transport ions across membranes
- Regulate membrane potentials
- Ca2+ influx into the cytoplasm
2
Q
What is an alpha helix?
A
Right hand-helix conformation
3
Q
What is a beta sheet?
A
Beta strands connected laterally by at least 2 or 3 backbone hydrogen bonds, forming a sheet
4
Q
What disease is caused by a mutation in nAChR?
A
Autosomal dominant nocturnal frontal lobe epilepsy
5
Q
What is the structure of glutamate receptors?
A
Tetrameric
6
Q
What is the structure of P2X receptors?
A
Trimeric
7
Q
How many transmembrane domains do GPCRs have?
A
7
8
Q
Where is the N terminus of GPCRs?
A
Extracellular
9
Q
Where is the C terminus of GPCRs?
A
Intracellular
10
Q
What are RGS proteins? (2)
A
- Regulators of G-protein signalling
- Stimulate GTPase activity in the alpha subunit
11
Q
What disease is caused by mutations in Gq alpha subunit? (2)
A
- Uveal melanoma
- GTP can’t be hydrolysed so always active
