Receptor and G-protein Flashcards by Jaclyn Possin

Q

Gq (g-protein) associates with which effector? And does it increase or decrease the effector?

A

Phospholipase C

Increase

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Q

Gi (g-protein) associates with which effector? And does it increase or decrease the effector?

A

Adenylate cyclase

Decrease

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Q

Gs (g-protein) associates with which effector? And does it increase or decrease the effector?

A

Adenylate cyclase

Increase

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Q

Alpha-1 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase C
Increase IP3, DAG, Ca2+

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Q

Alpha-2 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gi

Decrease adenylate cyclase
Decrease cAMP

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Q

Beta 1 & 2 receptors associate with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increase adenylate cyclase
Increase cAMP

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Q

Muscarinic 1/3/5 receptors associate with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase c
Increase IP3, DAG, Ca2+

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Q

Muscarinic 2/4 receptors associate with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gi

Decrease adenylate cyclase
Decrease cAMP

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Q

Dopamine 1 (postsynaptic) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increase adenylate cyclase
Increase cAMP

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Q

Dopamine 2 (presynaptic) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gi

Decrease adenylate cyclase
Decrease cAMP

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Q

Vasopressin 1 (vasculature) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase C
Increase IP3, DAG, Ca2+

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Q

Vasopressin 2 (renal tubules) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increase adenylate cyclase
Increase cAMP

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Q

Histamine 1 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase C
Increase IP3, DAG, Ca2+

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Q

Histamine 2 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increases adenylate cyclase
Increase cAMP

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Q

Which receptors are associated with Gq?

A

Alpha-1; Muscarinic 1/3/5; Vasopressin-1; Histamine-1

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Q

Which receptors are associated with Gs?

A

Beta 1 &2; Dopamine-1; Vasopressin-2; Histamine-2

Q

Which receptors are associated with Gi?

A

Alpha-2; Muscarinic 2/4; Dopamine-2

Q

What type of SNS and PNS receptor is associated with the Myocardium and heart conduction system?

What is the action?

A

SNS: Beta-1 (increased contractility, increased heart rate, increased conduction speed)

PNS: Muscarinic 2 (Decrease contractility, decreased heart rate, decreased conduction speed)

Q

What type of SNS and PNS receptor is associated with the arteries?

What is the action?

A

SNS: Alpha-1 > Alpha-2 (vasoconstriction)

PNS: none

Q

What type of SNS and PNS receptor is associated with the veins?

What is the action?

A

SNS: Alpha-2 > Alpha-1 (vasoconstriction)

Q

What type of SNS and PNS receptor is associated with skeletal/myocardial muscle vasculature bed?

What is the action?

A

SNS: Beta-2 (vasodilation)

PNS: none

Q

What type of SNS and PNS receptor is associated with the renal vasculature bed?

What is the action?

A

SNS: DA (vasodilation)

PNS: none

Q

What type of SNS and PNS receptor is associated with the mesenteric vasculature bed?

What is the action?

A

SNS: DA (vasodilation)

PNS: none

Q

What type of SNS and PNS receptor is associated with the bronchial tree?

What is the action?

A

SNS: Beta-2 (bronchodilation)

PNS: Muscarinic-3 (bronchoconstriction)

What type of SNS and PNS receptor is associated with the kidney's renal tubules? What is the action?

SNS: Alpha-2 (diuresis - ADH inhibition) PNS: none

What type of SNS and PNS receptor is associated with the kidney's renin release? What is the action?

SNS: Beta-1 (increased renin release PNS: none

What type of SNS and PNS receptor is associated with the eye's sphincter muscle (iris)? What is the action?

SNS: none PNS: Muscarinic (contraction - miosis) - constriction of the pupil

What type of SNS and PNS receptor is associated with the eye's radial muscle (iris)? What is the action?

SNS: Alpha-1 (contraction - mydriasis) - dilation of the pupil PNS: none

What type of SNS and PNS receptor is associated with the eye's ciliary muscle? What is the action?

SNS: Beta-2 (relaxation - far vision) PNS: Muscarinic (contraction - near vision)

What type of SNS and PNS receptor is associated with the gastrointestinal sphincters? What is the action?

SNS: Alpha-1 (contraction) PNS: Muscarinic (relaxation)

What type of SNS and PNS receptor is associated with the gastrointestinal tone? What is the action?

SNS: Alpha-1; Alpha-2; Beta-1; Beta-2 PNS: Muscarinic (increase)

What type of SNS and PNS receptor is associated with the gastrointestinal salivary glands? What is the action?

SNS: Alpha-2 PNS: Muscarinic (increase)

What type of SNS and PNS receptor is associated with the gallbladder and ducts? What is the action?

SNS: Beta-2 (relaxation) PNS: Muscarinic (contraction)

What type of SNS and PNS receptor is associated with the pancreas beta cells? What is the action?

SNS: Alpha-2 (decrease insulin release) Beta-2 (increase insulin release) PNS: none

What type of SNS and PNS receptor is associated with the Liver? What is the action?

SNS: Alpha-1/Beta-2 (increase serum glucose) PNS: none

What type of SNS and PNS receptor is associated with the Uterus? What is the action?

SNS: alpha-1 (contraction) | Beta-2 (relaxation)

What type of SNS and PNS receptor is associated with the bladder's trigone and sphincter? What is the action?

SNS: Alpha-1 (contraction) PNS: Muscarinic (relaxation)

What type of SNS and PNS receptor is associated with the bladder's detrusor? What is the action?

SNS: Beta-2 (relaxation) PNS: Muscarinic (contraction)

What type of SNS and PNS receptor is associated with the sweat glands? What is the action?

SNS: Alpha-1 (increased secretion) PNS: Muscarinic (increased secretion)