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Apex ANS > Receptor and G-protein > Flashcards

Receptor and G-protein Flashcards

1
Q

Gq (g-protein) associates with which effector? And does it increase or decrease the effector?

A

Phospholipase C

Increase

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2
Q

Gi (g-protein) associates with which effector? And does it increase or decrease the effector?

A

Adenylate cyclase

Decrease

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3
Q

Gs (g-protein) associates with which effector? And does it increase or decrease the effector?

A

Adenylate cyclase

Increase

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4
Q

Alpha-1 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase C
Increase IP3, DAG, Ca2+

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5
Q

Alpha-2 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gi

Decrease adenylate cyclase
Decrease cAMP

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6
Q

Beta 1 & 2 receptors associate with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increase adenylate cyclase
Increase cAMP

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7
Q

Muscarinic 1/3/5 receptors associate with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase c
Increase IP3, DAG, Ca2+

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8
Q

Muscarinic 2/4 receptors associate with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gi

Decrease adenylate cyclase
Decrease cAMP

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9
Q

Dopamine 1 (postsynaptic) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increase adenylate cyclase
Increase cAMP

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10
Q

Dopamine 2 (presynaptic) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gi

Decrease adenylate cyclase
Decrease cAMP

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11
Q

Vasopressin 1 (vasculature) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase C
Increase IP3, DAG, Ca2+

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12
Q

Vasopressin 2 (renal tubules) receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increase adenylate cyclase
Increase cAMP

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13
Q

Histamine 1 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gq

Increase phospholipase C
Increase IP3, DAG, Ca2+

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14
Q

Histamine 2 receptor associates with which G-protein?

List the effector (increase/decrease) and second messenger(s) (increase/decrease).

A

Gs

Increases adenylate cyclase
Increase cAMP

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15
Q

Which receptors are associated with Gq?

A

Alpha-1; Muscarinic 1/3/5; Vasopressin-1; Histamine-1

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16
Q

Which receptors are associated with Gs?

A

Beta 1 &2; Dopamine-1; Vasopressin-2; Histamine-2

17
Q

Which receptors are associated with Gi?

A

Alpha-2; Muscarinic 2/4; Dopamine-2

18
Q

What type of SNS and PNS receptor is associated with the Myocardium and heart conduction system?

What is the action?

A

SNS: Beta-1 (increased contractility, increased heart rate, increased conduction speed)

PNS: Muscarinic 2 (Decrease contractility, decreased heart rate, decreased conduction speed)

19
Q

What type of SNS and PNS receptor is associated with the arteries?

What is the action?

A

SNS: Alpha-1 > Alpha-2 (vasoconstriction)

PNS: none

20
Q

What type of SNS and PNS receptor is associated with the veins?

What is the action?

A

SNS: Alpha-2 > Alpha-1 (vasoconstriction)

21
Q

What type of SNS and PNS receptor is associated with skeletal/myocardial muscle vasculature bed?

What is the action?

A

SNS: Beta-2 (vasodilation)

PNS: none

22
Q

What type of SNS and PNS receptor is associated with the renal vasculature bed?

What is the action?

A

SNS: DA (vasodilation)

PNS: none

23
Q

What type of SNS and PNS receptor is associated with the mesenteric vasculature bed?

What is the action?

A

SNS: DA (vasodilation)

PNS: none

24
Q

What type of SNS and PNS receptor is associated with the bronchial tree?

What is the action?

A

SNS: Beta-2 (bronchodilation)

PNS: Muscarinic-3 (bronchoconstriction)

25
Q

What type of SNS and PNS receptor is associated with the kidney’s renal tubules?

What is the action?

A

SNS: Alpha-2 (diuresis - ADH inhibition)

PNS: none

26
Q

What type of SNS and PNS receptor is associated with the kidney’s renin release?

What is the action?

A

SNS: Beta-1 (increased renin release

PNS: none

27
Q

What type of SNS and PNS receptor is associated with the eye’s sphincter muscle (iris)?

What is the action?

A

SNS: none

PNS: Muscarinic (contraction - miosis) - constriction of the pupil

28
Q

What type of SNS and PNS receptor is associated with the eye’s radial muscle (iris)?

What is the action?

A

SNS: Alpha-1 (contraction - mydriasis) - dilation of the pupil

PNS: none

29
Q

What type of SNS and PNS receptor is associated with the eye’s ciliary muscle?

What is the action?

A

SNS: Beta-2 (relaxation - far vision)

PNS: Muscarinic (contraction - near vision)

30
Q

What type of SNS and PNS receptor is associated with the gastrointestinal sphincters?

What is the action?

A

SNS: Alpha-1 (contraction)

PNS: Muscarinic (relaxation)

31
Q

What type of SNS and PNS receptor is associated with the gastrointestinal tone?

What is the action?

A

SNS: Alpha-1; Alpha-2; Beta-1; Beta-2

PNS: Muscarinic (increase)

32
Q

What type of SNS and PNS receptor is associated with the gastrointestinal salivary glands?

What is the action?

A

SNS: Alpha-2

PNS: Muscarinic (increase)

33
Q

What type of SNS and PNS receptor is associated with the gallbladder and ducts?

What is the action?

A

SNS: Beta-2 (relaxation)

PNS: Muscarinic (contraction)

34
Q

What type of SNS and PNS receptor is associated with the pancreas beta cells?

What is the action?

A

SNS: Alpha-2 (decrease insulin release)
Beta-2 (increase insulin release)

PNS: none

35
Q

What type of SNS and PNS receptor is associated with the Liver?

What is the action?

A

SNS: Alpha-1/Beta-2 (increase serum glucose)

PNS: none

36
Q

What type of SNS and PNS receptor is associated with the Uterus?

What is the action?

A

SNS: alpha-1 (contraction)

Beta-2 (relaxation)

37
Q

What type of SNS and PNS receptor is associated with the bladder’s trigone and sphincter?

What is the action?

A

SNS: Alpha-1 (contraction)

PNS: Muscarinic (relaxation)

38
Q

What type of SNS and PNS receptor is associated with the bladder’s detrusor?

What is the action?

A

SNS: Beta-2 (relaxation)

PNS: Muscarinic (contraction)

39
Q

What type of SNS and PNS receptor is associated with the sweat glands?

What is the action?

A

SNS: Alpha-1 (increased secretion)

PNS: Muscarinic (increased secretion)

Apex ANS (1 decks)

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