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IL-3 > Receptor > Flashcards

Receptor Flashcards

1
Q

14564341: which human chromosome all three cytokine s

A

5

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2
Q

14564341:where are the receptors

A

pseudoautosomal regions of short arm of X-Y chromosome: IL-3 and GM-CSFRa
Chromosome 3: IL-5Ra
Chromosome 22: Common beta chain

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3
Q

14564341: 3 pathways down stream

A

JAK-STAT
MAPK (ERK, JNK p38)
PI3-Kinase

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4
Q

14564341: what are the cells in nature paper

A

mast cells and basophils (infection induced)

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5
Q

14564341: what is contrasting in GM-CSF vs IL-3 for DC polarization

A

GM-CSF for Th1 and IL-3 for Th2 promoting DCs from human monocytes

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6
Q

11207369: how many subunits in a dodecameric protein

A

12 (note: it is a quarternary structure look at last figure)

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7
Q

12055233: GM-CSF alpha chain CD number

A

CD116

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8
Q

12055233: human monocytes GM-CSF vs. IL-3

A

less IL-12p70 and IL-1beta and more IL-10: with IL-3 compared to GM-CSF

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9
Q

8543766: CD34+ CD33 low express

A

most IL-3 RA (but not useful since it is just one phase of the general lineage and not necessarily indicates any cell lineage)

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10
Q

9155834: asthma and GM-CSF R

A

mostly on intrinsic but not on atopic asthma

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11
Q

9600506: Fc(epsilon)RI-high dendritic cells express high levels of

A

CD123 (basophils also do)

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12
Q

19250840: plasmacytoid DC fraction in PBMC

A

0.2 to 0.8% human PBMC

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13
Q

19250840: what brings pDC to infected skin

A

chemerin (chemoattractant made by fibroblasts and endothelial cells)

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14
Q

18641647: what type of CPG ODN stimulate pDC

A

type A which causes pDC to make IFNa which then stimulate NK cells
Type B makes pDC to make IL-6 and TNF (good for antibody production)

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15
Q

18641647: full form of CpG ODN

A

oligo deoxy nucloetide
Cytidine guanosine sequence
TLR9

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16
Q

7579364: neutrophils express IL-3R after pre-Rx with

A

GM-CSF

17
Q

8100720: where are the receptors

A

GM-CSF and IL-3 both in in the PAR of X and Y

18
Q

12743324: Bone marrow contains - times more than peripheral blood of pDC

A

5 times

19
Q

wiki: origin of follicular DC

A

mesenchymal (they look like DC but not from BM)

20
Q

22930820: parasite induced IL-3 dependent - in BM and spleen

A

basophilia

21
Q

Sepsis science paper: highest IL-3R seen in

A

GMP: granulocyte macrophage
MDP: macrophage and dendiritc

22
Q

16174104: In human T cell clones, IL-3 and IL-13 was resultant of

A

GATA-3 (looks good)

23
Q

8934648: endothelial cells express IL-3R but not-

A

GMCSF R

24
Q

10527461: IL-3R expression in hematopoetic stem cells that are also positive for

A

CD34 (taken from different tissues) correlates with growth potential

25
Q

23226269: in brain IL-3R expressed in neural progenitors and neurons in the neonatal period

A

also correlates with brain volume

26
Q

8976174: apprently a dichotoomy of IL-3 and GM-CSF occurs in differentiation of

A

mDC and pDC

27
Q

11739152: surprise! pDC marker and growth in mice

A

B220 and CD11c+ Thy1.2+
NO proliferate but diffeentiate with IL-3 and anti-CD40
Note that they are FLT3 treated

28
Q

16174108 : pDC marker

A

CD11cint, CD4+/–, IL-3R– B220+ CD45RA+

29
Q

Miltenyi: pDC marker

A

mPDCA1 (BST-2)
Siglec H
CD11c low
CD11bNeg

30
Q

11017101: Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization

A

in humans

31
Q

25137390: IL-3 beta chain can bind to IL-3 without alpha but —

A

can’t do signaling

32
Q

1582416: Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).

A

gives a schematic

33
Q

19281803: mental disese that is connected to IL-3R

A

schizophrenia

34
Q

14730712:autocrine activator in brain

A

microglia (main source is also microglia)

35
Q

8806599: Expression of IL-3 receptor in testis.

A

Leydig cells

36
Q

7727767: C57BL/6 and BALB/c expresses correct

A

IL-3Ra (many lab strains don’t, but wild do)

37
Q

Lack (11713464) or less (12438422) CD123 on pDC

A

15254595 (but Mellor shows expression)

IL-3 (8 decks)

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