Reagents Flashcards
H3O+, Heat
——————>
Removes any COOR type group
Ex: CO2CH3
1) NaOtBU
- ————–>
2) Heat
Robinson Annulation
H2, Pd / C
—————–>
Reducing agent
Reduces =O to –OH
1) NaH
- ———>
2) CH3I
Adds Methyl
Presumably can do this with anything attached to I if you use NaH first
1) NaOEt
- ————>
2) H3O+
Claisen Reaction
X2
———–>
NaHCO3
Adds a halogen (X)
Removes any COOR type group
Ex: CO2CH3
H3O+, Heat
——————>
Robinson Annulation
1) NaOtBU
- ————–>
2) Heat
Reducing agent
Reduces =O to –OH
H2, Pd / C
—————–>
Adds Methyl
Presumably can do this with anything attached to I if you use NaH first
1) NaH
- ———>
2) CH3I
Claisen Reaction
1) NaOEt
- ————>
2) H3O+
Adds a halogen (X)
X2
———–>
NaHCO3
Adding halogen to a benzene ring
X2
——>
Fe2X3
X= Cl or Br
X2
——–>
Fe2X3
X= Cl or Br
Adding a halogen to a benzene ring
Adding X2 across an alkene double bond
C=C —-> X-C-C-X
*Does NOT work on benzene rings
X2
——->
Dark
X2
——>
Dark
Adding X2 across an alkene double bond
C=C —-> X-C-C-X
*Does NOT work on benzene rings
Most common reducing agent – Reduces pretty much anything to H
H2, Pd/C
————–>
Adding NO2 to a benzene ring
HNO3
———>
H2SO4
HNO3
———->
H2SO4
Adding NO2 to a benzene ring
Friedel-Crafts Alkylation (adding an alkyl group onto a benzene ring)
AlCl3
———>
Cl(Alkyl)
*Does NOT work if there is a nitro (NO2) group already on benzene ring
AlCl3
———>
Cl(Alkyl)
*Does NOT work in presence of NO2
Friedel-Crafts Alkylation (adding an alkyl group onto benzene ring)
How to replace a halogen for an NH2 group on a benzene ring
NH3
——->
Excess
NH3
——–>
Excess
Replaces a halogen for an NH2 group on a benzene ring
Replaces a halogen with an OH group on a benzene ring
1) NaOH, Heat
- ——————->
2) NaCl, pH 7
