Readings Flashcards
What causes Superficial Bleeding
Platelet Defect or Vascuar Disorder
What causes Deep Tissue Bleeding
Plasma Clotting Factor Deficiencies
Superficial Bleeding is characterized by
Petechiae
Epistaxis
Gingival bleeding
Deep Tissue Bleeding is characterized by
Hematomas
Hemarthrosis
Abnormal IN VITRO clot retraction
GLANZMANN
THROMBASTHENIA
Less affected by abnormal clot retraction and fibrinogen binding
Type II Diabetes
BSS does not respond to:
Riscotecin
Hermansky Pudlak Syndrome is linked to what Chromosome
19
Hermnsky Pudlak Syndrome is characterized by ___ appearance of platelet
Swiss Cheese Platelet
Defective lysosomal function in a variety of cells
Hermansky Pudlak Syndrome
Tyrosinase positive oculocutaneous albinism
Hermnsky Pudla Syndrome
Partial oculucutaneous albinism
Chediak Higashi Syndrome
85% progresses to Lymphocytic proliferation in the liver, spleen, and marrow with macrophage accumulation in tissues
Chediak Higashi Syndrome
There is a frequen pyogeni bacterial infections
Chediak Higashi Syndrome
Giant lysosomal Granules
Chediak Higashi Syndrome
WAS is caused by mutation in what WAS gene
Short arm of X chromosome Xp. 11.23 that encodes fr a 502-amino acid protein
Phenotypes present in WAS
50% WAS
50% XLT
Feature of diagnostic importance in WAS
Microthrmobocytes
Patients lack the ability to make Anti-Polysaccharide atibodies
Eczema Thrombocytopenia Immunodeficiency Syndrome
Classic form of WAS
ETIS
TAR is characterized by congenital absence of
Radial bones
90% of cases have thrombocytopenia
TAR
