reactions Flashcards
1
Q
Does substitution reactions prefer hot or cold
A
cold
2
Q
EtOH + Cold
A
SN1
3
Q
HBr
A
SN1
4
Q
AgNO3
A
SN1
5
Q
KBr
A
SN2
6
Q
excess NH3
A
SN2
7
Q
DMF
A
SN2 + POLAR APROTIC
8
Q
DMSO
A
SN2 + POLAR APROTIC
9
Q
Acetone
A
SN2 + POLAR APROTIC
10
Q
PBr3
A
SN2
11
Q
PCl3
A
SN2
12
Q
NaCN
A
SN2
13
Q
H2SO4/pTsOH
A
E1 (favours zaitsev)
14
Q
EtOH + Hot
A
E1
15
Q
H+/Heat on 2°/3° Carbon
A
E1
16
Q
NaOEt
A
E2 (Zaitsev)
17
Q
KOH
A
E2 (Zaitzev)
18
Q
kOtBu
A
E2
19
Q
NaOH
A
E2
20
Q
what does TsCl do
A
improves LG ability
commonly used with pyridine
maintains stereochem
21
Q
What does SOCl2 do
A
converts alcohol to alkyl chloride
commonly used with Et3N
22
Q
what does NaCN do
A
replaced LG with CN
23
Q
what does excess NH3 do
A
replaces LG with NH2
24
Q
does potassium tert butoxide prefer zaitsev or anti-zaitsev
A
anti
25
what is constitutional isomer
atoms (w/same molecular formula) connected differently
may get diff functional group
26
what is conformational isomers
atoms connected the same but one is just rotated
27
what are enatiomers
mirror
28
what is geometric
whether its cis or trans
29
what Nu does SN1/E1 prefer
netural
30
what Nu does SN2/E2 prefer
Usually charged
31
what does SN1/E1 prefer: protic or aprotic
polar protic (can donate H)
32
what does SN2/E2 prefer: protic or aprotic
polar aprotic (Cannot donate H)
33
LDA
E2
34
Stepwise
SN1 and E1
35
concerted
SN2 and E2
36
maintains stereochem
SN1
37
does not maintain stereochem
SN2
38
OH
weak LG
Strong base
39
hydronium
strong acid
turned into water = good LG/Weak base
40
NaSH
SN2
41
rank carbocations from least to most stable
Vinyl < Methyl < primary < secondary = allylic ≈ benzyl < tertiary
42
alcohol/HX
SN1
43
alcohol/SOCl2 or PX3
SN2
44
alhyl halide/NaI/acetone
SN2
45
alkyl halide/water
E1
46
Alcohol/H2SO4/heat
E1
47
alkyl halide/KOH/heat
E2
48
what are alkyl halides
structures bonded to F, Cl, Br, and I
49
