RBC[Rabe] Flashcards
T or F: blood does not have buffering capacity.
FALSE
It is a buffer, slightly alkaline, pH 7.35-7.45
Ppt
T or F: blood can be used to regulate temperature
TRUE
Ppt,lec
What contributes to blood viscosity?
Formed elements
Lec
Classify blood according to type of tissue.
Specialized connective tissue
-Because its binds tissues together, it is not compact
Ppt and Lec
What accounts for largest amount of formed elements in the blood?
RBC/ ERYTHROCYTES
Lec
What is RBC/total blood volume?
Hematocrit
Definition
Composidtion of plasma?
- WATER
- PLASMA PROTEINS
- CLOTTING FACTORS
Lec
What is the average hematocrit of male and female. Is it the same for both?
Not the same!
Male: 45% to 50%
Female: 40% to 45 %
Ppt
Absent is serum but present in plasma!
Clotting factors
Lec
Clot is formed when blood gets into contact with… (3)
- GLASS
- ANIONIC SURFACE
- NEGATIVELY CHARGED SURFACE
LEC
Enumerate the three important plasma proteins.
- Albumin
- Globulins
- Fibrinogen
PPT_9
What Type of formed elements responsible for oxygen transport?
ERYTHROCYTES
PPT
What is the function of white blood cells?
Takes part in IMMUNE SYSTEM
PPT
What are the Cell fragments that isminvolved in clotting?
PLATELETS
PPT
Plasma protein that:
- Is Major contributor to OSMOTIC PRESSURE of Plasma
- TRANSPORTS lipid, steroid, hormone
ALBUMINS
PPT
Plasma protein that:
- TRANSPORT lipid, ions, hormones,
- Has IMMUNE FUNCTION
GLOBULINS
PPT
Plasma protein that is
- Is Essential component of CLOTTING system
- Can be converted to FIBRIN
FIBRINOGEN
PPT
What constitutes regulatory proteins inside plasma?
- ENZYMES
- PROENZYMES
- HORMONES
PPT
What Constitutes 35% of plasma proteins?
GLOBULINS
PPT
What is the Most abundant plasma protein? Give its percentage.
ALBUMIN -60%
PPT
T or F: Fibrinogen constitutes 40% of plasma proteins.
FALSE!
4% only
PPT
Plasma component:
1. That TRANSPORT inorganic and organic molecules, formed elements and heat
WATER
PPT
Major Plasma component in terms of abundance
WATER
PPT
T or F: there is relatively few electrolytes in blood plasma
TRUE
Part of 1% only
PPT_11
What are the other (minor) solutes present in blood plasma?
- ELECTROLYTES
- ORGANIC NUTRIENTS
- ORGANIC WASTES
T or F: the blood contains ions that contribute to osmotic pressure of body fluids.
TRUE
electrolytes in plasma
PPT_11
T or F: amino acids can be carried by blood.
TRUE
PPT_11
Five the normal values of RBC in males and females.
Male: 5.2 million
Female: 4.7 million
PPT_12
How long is RBC’sAverage lifespan?
100 – 120 days
PPT_13
What is the term used to refer tomstacked RBCs?
Rouleau
PPT_14
These Maintains structural integrity and biconcave shape of RBC.
- ANKYRIN
- SPECTRIN
PPT_15, TRANS_2
T or F: Hereditary spherocytosis is caused by Weak interactions amongst peripheral and integral proteins.
TRUE!
PPT_16
It Catalyzes couple transport of anions.
BAND 3
under mem proteins
PPT_18
T or F:band 3 inhibits HCO3 to cross membrane in exchange for Cl;
FALSE!
It allows!
PPT_18
T or F: Chloride ion and bicarbonate ion passes through the same integral protein.
TRUE
BAND 3
PPLt_19
Enumerate normal hemoglobin component.
- Four globular protein units
- alpha chain 1
- alpha chain 2
- beta chain 1
- beta chain 2
- Heme containing the iron
PPT_20
What is the Protein molecule in the blood that transports respiratory gases?
HEMOGLOBIN
PPT_20
T or F: Late in the second month the liver and spleen take over blood formation.
TRUE
PPT_23
Sa guyton “ ‘mid-trimester”
Bones that persist as hematopoietic region until adulthood.
FLAT BONES
- ribs
- Sternum
- Hip
PPT_23
Enumerate erythropoiesis sites
In the red bone marrow in
- long bones,
- cranial bones,
- ribs,
- sternum, and
- vertebrae
PPT_24
What is the Source of all blood cells?
Pluripotetial hematopoetic stem cell
PPT_25
T or F: abundance of oxygen in tissues initiates production of Erythropoietin.
FALSE!
Hypoxia causes
PPT_26
These augments EPO synthesis (4)
- testosterone,
- growth hormone,
- insulin
- growth like factor 1
steps in erythropoietin synthesis?
- HYPOXIA
- Stimulation of HYPOXIA INDUCIBLE FACTOR
- Binds HYPOXIA RESPONSE ELEMENT in DNA •
- Stimulation of EPO GENE EXPRESSION
- Synthesis of EPO
PPT_27
is a decrease in red blood cells that occurs when your intestines cannot properly absorb vitamin B12.
Pernicious anemia
PPT_29,net definition
T or F: RBC synthesis requires Vitamin B12 or FOLIC ACID.
FALSE!
And not or! It needs both
PPT_29
Products of hemoglobin conversion
- AMINO ACIDS
- —from globulins - BILIVERDIN
- —from heme - Iron
PPT_31
What is the precursor of biliverdin?
HEME
PPT_33
What is the Precursor of urobilins and stercobilins?
Bilirubin
PPT_33
A product of bilirubin that is eliminated in urine.
UROBILINS
PPT_33
A product of bilirubin that is eliminated in feces.
STERCOBILINS
PPT_33
T or F: Biliverdin gets converted to bilirubin INSIDE MACROPHAGES in liver, spleen, and bone marrow.
TRUE!
PPT_33
T or F: Amino acid from phagocytosed RBC are transported back to red bone marrow for recycling.
TRUE
PPt_33
Depressed hematocrit translate to what kind of condition?
ANEMIA
PPT_35
These Are cell surface proteins that identify cells to immune system.
Surface Antigens
PPT_36
T or F: Rhogam is an Rh(D) immunoglodulin.
TRUE
PPT_45
What RBC membrane protein:
- Allows for integral structure of RBC membrane
- Maintains RBC shape
- Allows flexibility of RBC
SPECTRIN
TRANS_2
T or F: most of Glycophorin mass lies on cytoplasmic side.
FALSE!
External
Trans_2
What substance accounts for the negative charge on RBC surface?
SCIALIC ACID
Trans_2
What transport is catalyze s by band 3 membrane protein?
COUPLE TRANSPORT OF ANIONS
TRANS_3
What specific RBC membrane protein is responsible for delivering CO2 from tissues to lungs?
BAND 3 PROTEIN
Trans_3
What RBC component contains iron?
HEME
Trans_3
What amino acid is replaced by valine on the case of sickle cell anemia?
GLUTAMIC ACID
Trans_3
What is the most common hemoglobin?
HEMOGLOBIN A!
TRANS_3
Which part of the body is there:
- highest oxygen tension
and - Lowest oxygen tension ?
- ALVEOLI of lungs
- TISSUES
TRANS_3
Condition wherein body can’t absorb enough iron from the intestines as rapidly as it is lost.
BLOOD LOSS ANEMIA
TRANS_4
A condition in which bone marrow aplasia cause deficient production of blood cells.
APLASTIC ANEMIA
Trans_4
Condition caused by loss of vit. B12 (cyanocovalamin), folic acid (impt in
synthesis of thymidine) or intrinsic factor from the stomach mucosa that lead to very slow reproduction of erythroblasts in bone marrow
MEGALOBLASTIC ANEMIA
TRANS_4
Conditions caused by presence of Hemoglobin S in RBC
SICKLE SHAPED ANEMIA
TRANS_4
T or F: in hereditary spherocytosis the RBCscan’t withstand compression forces and are easily ruptured by even slight compression
TRUE
trans_4
Conditions characterized by Red blood cells being too large, with odd shapes
MEGALOBLASTIC ANEMIA
TRANS_4
Condition wherein Rh(+) RBCs in fetus are attacked by antibodies from Rh(-) mothers
Erythroblastosis fetalis
Trans_4
Most responsible organ in detecting oxygen level of the body.
- KIDNEY – 90%
- LIVER –10%
- SKIN
- BRAIN
TRANS_5
Protein Supporting terminal erythroid differentiation and proliferation.
ERYTHROPOIETIN
Trans_5
Gene that promotes apoptosis.
GATA2
Trans_5
Enumerate hormones that stimulate erythropoietin production
- Norepinephrine,
- Epinephrine &
- Prostaglandin
Trans_5
Nucleoside triphosphate that needs vitamin b12 and folic acid.
THYMIDINE TRIPHOSPHATE
TRANS_5
Enumerate possible effects of vitamin b12 and folic acid defficiency.
- Abnormal and diminished DNA -> failure of
nuclear maturation and cell division - Erythroblastic cells of bone marrow fail to
proliferate rapidly and produce mainly larger than normal red cells called MACROCYTES
Trans_5
T or F: eextrinsic factor in GIT is essential in vitamin b12 ansorption.
FALSE!
Intrinsic dapat.
Trans_5
T or F: 10% of circulating RBCs wear out per day.
FALSE!
1% lang
Trans_5
Responsible for breakdown of hemoglobin.
Macrophages of
- liver,
- spleen, and
- bone marrow
Trans_5
What do you call deposit of iron that cannot be dissolved anymore and a useful indicator of disease?
HEMOSIDERIN
trans_6
What od you call those extra stored iron?
FERRITIN
trans_6
T or F: secondary polycythemia is an innate function in immunity.
FALSE!!
Adaptive
Trans_6
Condition that results in production of all 3 blood cells.
Polycythemia vera (Erythremia)
Trans_6
Name the reaction: If a blood transfusion is given to a person who has antibodies to that type of blood, then the transfused blood will be attacked and destroyed
TRANSFUSION REACTION
TRANS_7
T or F: Rh factor is x-link gene.
FALSE!!
Autosomal recessive.
Trans_7
What is thePrescription for pregnant Rh- moms?
Rhogam
Trans_7
Donor RBC + Recipient serum
MAJOR CROSS MATCH
TRANS_7
Donor plasma + recipient RBC
MINOR CROSS MATCH
TRANS_7
