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Hematology 1 fall 2022 > RBC Morphology to Diseases and symptoms > Flashcards

RBC Morphology to Diseases and symptoms Flashcards

1
Q

Acanthocytes

A

Abetalipoproteinemia
Severe liver disease
Splenectomy
Malabsorption
Hypothyroidism
Vitamin E deficiency

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2
Q

Burr cell

A

Uremia
PK deficiency
Microangiopathic hemolytic anemia
Neonates (especially premature)
Artifact

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3
Q

Spherocytes

A

Hereditary Spherocytosis
Some hemolytic anemias
Transfused cells
Severe Burns

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4
Q

Target cell

A

Hemoglobinopathies
Thalassemia
Iron deficiency anemia
Splenectomy
Obstructive liver disease

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5
Q

Sickle cell

A

Homozygous hemoglobin S disease

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6
Q

Hemoglobin C crystals

A

Homozygous hemoglobin C disease

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7
Q

Hemoglobin SC crystals

A

Hemoglobin SC disease

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8
Q

Stomatocyte

A

Hereditary stomatocytosis
Alcoholism
Liver disease
Rh null phenotype
Artifact

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9
Q

Elliptocyte / Ovalocyte

A

1.Hereditary elliptocytosis or ovalocytosis
2.Thalassemia major
3.Iron deficiency anemia
4.Megaloblastic anemias (oval macrocyte)
5.Myelophthisic anemias

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10
Q

Teardrop cell

A

1.Myelofibrosis with myeloid metaplasia
2.Thalassemias
3.Myelophthisic anemias
4.Causes of extramedullary hematopoiesis

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11
Q

Schistocyte

A

Microangiopathic hemolytic anemia
Severe burns
Hemolytic uremic syndrome
Thrombotic thrombocytopenic purpura
Renal graft rejection

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12
Q

Rouleaux

A

Increased concentration of globulins and / or paraproteins

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13
Q

Autoagglutination

A

Antigen / antibody reactions

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14
Q

Normocyte

A

Normal shape with center of pallor or none

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15
Q

Microcyte

A

Iron deficiency anemia
Sideroblastic anemia
Thalassemia minor
Chronic disease (occasionally)
Lead poisoning
Hemoglobinopathies (some)

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16
Q

Macrocyte

A

Occurs b/c of impaired dna synthesis. (exclude babies)
There may be some asynchrony
1. Liver disease
2. Vitamin B12 deficiency
3. Folate deficiency
4. Neonates

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17
Q

Dimorphic populations of RBCs

A

Transfusion
Myelodysplastic syndromes
Folate or Fe deficiencies; early in treatment process

18
Q

Hypochromia

A

Occurs b/c of issue with hemoglobin synthesis.
Iron deficiency anemia
Thalassemias
Sideroblastic anemia
Lead poisoning
Some cases of chronic infllamation

19
Q

Polychromasia

A

Acute and chronic hemorrhage
Hemolysis
Effective treatment for anemia
Neonates

20
Q

Another name for acanthocytes?

A

Spur cells

21
Q

Other names for burr cells

A

Echinocyte or crenated cells

22
Q

Another name for target cells

A

codocytes

23
Q

Another name for sickle cell

A

Drepanocyte

24
Q

Another name for teardrop cells

A

Dacryocytes

25
Q

Another name for schistocytes (not shitocytes)

A

Schizocyte

26
Q

Size of RBCs (normo, micro, or macrocytes) corresponds to what parameter?

A

Normo MCV 80 - 100
Micro MCV < 80
Macro MCV > 100

27
Q

What parameter suggests dimorphic populations of RBCs?

A

RDW greater than 14.5%

28
Q

What parameter suggests hypochromia?

A

MCHC <32 g/ dL or 32%

29
Q

What are the inclusions in cabot’s rings?

A

Remnants of Mitotic spindles. May be seen in any patient that has deficiencies in folate, B12 or have macrocytes .

30
Q

Howell - jolly bodies have what inside them?

A

Nuclear aggregates. May be seen in patients that have gone through splenectomy. Be aware an artifact can make RBCs look like they are jolly bodies.

31
Q

What are inclusions of basophillic stippling?

A

Degenerated RNA.

32
Q

What are inclusions of pappenheimer bodies?

A
33
Q

What are the inclusions in Hgb bars or crystals?

A
34
Q

How are crenated forms of RBCs made?

A

Using too much blood to make blood smear slide. Too much blood makes the slide dry too slowly to turn RBCs into crenated RBCs.

35
Q

Naturally occurring crenated RBCs (burr cells) is associated with what?

A

PK deficiency
Uremia

36
Q

How many elliptocytes or ovalocytes do there need to be for a patient to have hereditary elliptocytosis in percentages?

A

Greater than 30%

37
Q

What are the inclusions of heinz bodies made of?

A

Denatured Hgb.

38
Q

When are basophilic stippling found?

A

Found in states of impaired Hgb synthesis like sideroblastic anemias, uremia, cancer, megaloblastic anemias, repeated transfusions and post splenectomy

39
Q

Heinz bodies found in a patient suggest

A

G6PD deficiency

40
Q

Howell Jolly bodies suggest patient has

A

Severe hemolytic and megaloblastic anemia, splenectomy, anemias associated with leukemia

41
Q

Siderocytes / pappenhiemer bodies are associated with

A

Impaired Hgb synthesis (sideroblastic anemias), uremia, cancer, megaloblastic anemias, post - repeated transfusions, and post - splenectomy

42
Q

Cabot’s Rings can be associated with?

A

Impaired DNA synthesis, megaloblastic anemias, or myelodysplastic syndromes

Hematology 1 fall 2022 (3 decks)

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