RBC Disorders Flashcards
In chronic inflammation, hepcidin is (increased/decreased)
increased
Chronic inflammation → increased hepcidin → decreased Fe absorption -→ not enough hemoglobin → iron deficiency w/ chronic disease
In iron deficiency, hepcidin is (increased/decreased)
decreased
Iron (hepcidin) deficiency → decreased hepcidin → increase absorption of iron
Hepcidin (increases/decreases) iron absorbption.
decreases
Vegans are prone to ___ deficiency
B12
Alcoholics are prone to ___ deficiency
folate
High or low RI?
Aplastic anemia
Low
High or low RI?
Iron, B12 or folate deficiency
Low
High or low RI?
Thalassemia
High
High or low RI?
Low EPO, thyroid hormone, androgen
Low
High or low RI?
Autoimmune hemolytic anemia
High
Micro, normo or macrocytic anemia?
Iron deficiency anemia
Microcytic
Normocytic when early
Micro, normo or macrocytic anemia?
Aplastic anemia
Normocytic
Micro, normo or macrocytic anemia?
Inflammation/chronic disease
Micro or normocytic
Micro, normo or macrocytic anemia?
Folate deficiency
Macrocytic
Micro, normo or macrocytic anemia?
B12 deficiency
Macrocytic
Micro, normo or macrocytic anemia?
Thalassemic disorder
Microcytic
Micro, normo or macrocytic anemia?
Hemolytic anemia
Macrocytic
Micro, normo or macrocytic anemia?
Drugs
Macrocytic
Micro, normo or macrocytic anemia?
Liver disease
Macrocytic
B12 or Folate deficiency?
NO hx autoimmune
NO glossitis, neurologic signs
Folate
B12 have all these signs:
Hx of autoimmune
Glossitis
Neurologic signs: gait ataxia, position/vibration sense, Stocking and glove
Name the disease:
Hypersegmented PMN on blood smear
B12/Folate deficiency
Name the disease:
Central pallor on blood smear
Iron deficiency
Expected levels in Iron Deficiency: MCV: Hgb: RI: ferritin: transferrin: serum Fe: erythrocyte protoporphyrin:
MCV: micro RI: low Hb: low Ferritin: low Transferrin: high Serum iron: low Protoporphyrin: high
Expected levels in B12 Deficiency: MCV: Hgb: RI: WBC: PMN:
MCV >100 (macro) Low Hgb Low RI Slightly low WBC Low PMN
Expected levels in Folate Deficiency: MCV: Hgb: RI: WBC: PMN:
MCV >100 (macro) Low Hgb Low RI Slightly low WBC Low PMN
Expected levels of Anemia of Chronic Disease: MCV: Hgb: RI: WBC: PMN:
MCV micro or normo
Low RI
Low Hgb
Normal WBC, plt
Expected levels of Thalassemia:
MCV:
Hgb:
RI:
MCV: micro
RI: high
Hb: low
Name the disease:
Target cells on blood smear
Thalassemia
Name the disease:
Rouleaux formation on blood smear
Anemia due to multiple myeloma
Expected levels of Anemia due to Primary Bone Marrow Disorder:
MCV:
RI:
WBC,plt:
MCV: macro
RI: low
WBC,plt: abnormal
