RBC Disorders

Question 1

In chronic inflammation, hepcidin is (increased/decreased)

Answer 1

increased

Chronic inflammation → increased hepcidin → decreased Fe absorption -→ not enough hemoglobin → iron deficiency w/ chronic disease

Question 2

In iron deficiency, hepcidin is (increased/decreased)

Answer 2

decreased

Iron (hepcidin) deficiency → decreased hepcidin → increase absorption of iron

Question 3

Hepcidin (increases/decreases) iron absorbption.

Answer 3

decreases

Question 4

Vegans are prone to ___ deficiency

Answer 4

B12

Question 5

Alcoholics are prone to ___ deficiency

Answer 5

folate

Question 6

High or low RI?

Aplastic anemia

Answer 6

Low

Question 7

High or low RI?

Iron, B12 or folate deficiency

Answer 7

Low

Question 8

High or low RI?

Thalassemia

Answer 8

High

Question 9

High or low RI?

Low EPO, thyroid hormone, androgen

Answer 9

Low

Question 10

High or low RI?

Autoimmune hemolytic anemia

Answer 10

High

Question 11

Micro, normo or macrocytic anemia?

Iron deficiency anemia

Answer 11

Microcytic

Normocytic when early

Question 12

Micro, normo or macrocytic anemia?

Aplastic anemia

Answer 12

Normocytic

Question 13

Micro, normo or macrocytic anemia?

Inflammation/chronic disease

Answer 13

Micro or normocytic

Question 14

Micro, normo or macrocytic anemia?

Folate deficiency

Answer 14

Macrocytic

Question 15

Micro, normo or macrocytic anemia?

B12 deficiency

Answer 15

Macrocytic

Question 16

Micro, normo or macrocytic anemia?

Thalassemic disorder

Answer 16

Microcytic

Question 17

Micro, normo or macrocytic anemia?

Hemolytic anemia

Answer 17

Macrocytic

Question 18

Micro, normo or macrocytic anemia?

Drugs

Answer 18

Macrocytic

Question 19

Micro, normo or macrocytic anemia?

Liver disease

Answer 19

Macrocytic

Question 20

B12 or Folate deficiency?
NO hx autoimmune
NO glossitis, neurologic signs

Answer 20

Folate

B12 have all these signs:
Hx of autoimmune
Glossitis
Neurologic signs: gait ataxia, position/vibration sense, Stocking and glove

Question 21

Name the disease:

Hypersegmented PMN on blood smear

Answer 21

B12/Folate deficiency

Question 22

Name the disease:

Central pallor on blood smear

Answer 22

Iron deficiency

Question 23

Expected levels in Iron Deficiency:
MCV:
Hgb:
RI:
ferritin:
transferrin:
serum Fe:
erythrocyte protoporphyrin:

Answer 23

MCV: micro
RI: low
Hb: low
Ferritin: low
Transferrin: high
Serum iron: low
Protoporphyrin: high

Question 24

Expected levels in B12 Deficiency:
MCV:
Hgb:
RI:
WBC:
PMN:

Answer 24

MCV >100 (macro)
Low Hgb
Low RI
Slightly low WBC
Low PMN

Question 25

Expected levels in Folate Deficiency:
MCV:
Hgb:
RI:
WBC:
PMN:

Answer 25

MCV >100 (macro)
Low Hgb
Low RI
Slightly low WBC
Low PMN

Question 26

Expected levels of Anemia of Chronic Disease:
MCV:
Hgb:
RI:
WBC:
PMN:

Answer 26

MCV micro or normo
Low RI
Low Hgb
Normal WBC, plt

Question 27

Expected levels of Thalassemia:
MCV:
Hgb:
RI:

Answer 27

MCV: micro
RI: high
Hb: low

Question 28

Name the disease:

Target cells on blood smear

Answer 28

Thalassemia

Question 29

Name the disease:

Rouleaux formation on blood smear

Answer 29

Anemia due to multiple myeloma

Question 30

Expected levels of Anemia due to Primary Bone Marrow Disorder:
MCV:
RI:
WBC,plt:

Answer 30

MCV: macro
RI: low
WBC,plt: abnormal