RBC disorder buzz words

Question 1

Dx by electrophoresis - see Hgb H

Answer 1

Thalasseia alpha

Question 2

Dx by electrophoresis - see Hgb F, A2

Answer 2

Thalassemia beta

Question 3

periph smear shows anisocytosis, poikilocytosis

Answer 3

iron def

B12 def

Question 4

periph smear shows macro-ovalocytes

Answer 4

folate def

b12 def

Question 5

periph smear shows hypersegmented PMN

Answer 5

folate def

b12 def (hypersegmented neutrophils)

Question 6

periph smear shows Howell-Jolly bodies

Answer 6

folate def

sickle cell anemia

Question 7

labs show intrinsic factor antibody

Answer 7

pernicious (b12) anemia

Question 8

acute chest syndrome

Answer 8

sickle cell

Question 9

Hgb S electrophoresis

Answer 9

sickle cell anemia

Question 10

periph smear shows target cells

Answer 10

sickle cell anemia

alpha or beta thalassemia

Question 11

periph smear shows nucleated RBCs

Answer 11

sickle cell anemia

beta thalassemia

Question 12

periph smear shows bite cells, Heinz bodies

Answer 12

G6PD def

Question 13

increased homocysteine only

Answer 13

folate

Question 14

increased homocystine and increased MMA

Answer 14

b12

Question 15

patient is 6 months of age

Answer 15

thalassemia beta

sickle cell anemia

Question 16

JAK2 mutation

Answer 16

polycythemia vera

Question 17

ADAMTS13

Answer 17

TTP

Question 18

basophilic stippling

Answer 18

sideroblastic anemia

Question 19

schistocyte morphology

Answer 19

TTP

DIC

Question 20

PT is increased

Answer 20

(indicates extrinsic problem)

TTP

DIC

Question 21

PTT is increased

Answer 21

(intrinsic pathway)

Hemophilia A/B

vWD

DIC

Question 22

TT increased

Answer 22

DIC

Question 23

Platelets low

Answer 23

DIC, TTP