RBC AND WBC Flashcards
- After 20 years of age red cell production is abundant in… except ..
Long bones
Sternum
Pelvis
Vertebra
Vertebra
- What stage of red blood cells that passes into the blood capillaries by diapedesis? A. Basophil erythroblast B. Reticulocyte C. Proerythroblast D. Erythrocyte *Leukocytes
D. erythrocytes
**leukocytes
- Which of these does not cause hypoxia? A. Pneumonia B. Anemia C. Hypercapnia D. Obstructive respiratory disease
C. Hypercapnia
Hypercapnia, also called hypercarbia, iswhen you have too much carbon dioxide (CO2) in your blood
Hypoxia
a state in which oxygen is not available in sufficient amounts at the tissue level to maintain adequate homeostasis
- Process of neutrophils sticking to damaged capillary walls
A. Margination B. Chemotaxis C. Diapedesis
A. Margination
.Most important test to check that anemia is caused by blood loss?
Hemoglobin concentration
- Which of the following condition is not considered a porphyria? *
A. X-linked sideroblastic anemia
B. ALA dehydratase deficiency
C. acute intermittent porphyria
D. porphyria cutanea tarda
A. X-linked sideroblastic anemia
- A person with type A blood has
A. A agglutinogen
B. B agglutinogen
C. Anti-A agglutinin
D. Anti-B agglutinin
C. Anti-A agglutinin
- What is the major protein in the
cytoskeleton of red blood cells? *
A. Actin
B. Ankyrin
C. Spectrin
D. Glycophorin
C. Spectrin
- A woman has been suffering from heavy menstrual cycles for years. She is on a vegan diet. What is she at most risk of?
A. Anemia B. Leukopenia C. Thrombocytopenia D. polycythemia vera
A. Anemia
- What type of anemia is caused by poor absorption of vitamin B12 and often seen in patients after removal of the intestines?
A. Sickle cell anemia
B. Megaloblastic Anemia
C. Iron deficiency anemia
D. Pernicious Anemia
D. Pernicioud Anemia
- The role of basophils in acute inflammatory response, EXCEPT
a. release effectors that activates platelets b. release histamine that facilitate edema formation
c. secretes chemokines that attract lymphocytes
d. release chemokines that facilitates vascular constriction
a. release effectors that activates platelets
- Which among the white blood cells has a tendency to live for many years? A. Lymphocytes (memory lymphocyte) B. EosinophilsC. Neutrophils D. Monocytes
A. Lymphocytes
- Which of the following best defines diapedesis?
A. Migration of leukocytes in response to signals produced in sites of infection
B. Locomotion of leukocytes to migrate in response to stimuli
C. Leukocytes encapsulate invading bacteria within membrane vesicles
D. Process of traversing the capillary wall in response to chemical signals
D. Process of traversing the capillary wall in response to chemical signals *mechanism of movement for leukocytesameboid
- What is the direct role of G-protein in chemotaxis? * A. Hydrolyzes diacylglycerol to increase the cytoplasmic Ca2+
B. Stimulates protein kinase C to induce translocation
C. Activates phospholipase C to produce diacylglycerol and IP3
D. Activates IP3 which then catalyzes phosphorylation of various proteins
C. Activates phospholipase C to produce diacylglycerol and IP3
- Which of these cells is also commonly known as polymorphonuclears?
A. Monocyte
B. Lymphocyte
C. Basophil
D. Neutrophil
D. Neutrophil
53.Not a macrophage?
Histiocytes-Skin
- Which does not describe polycythemia vera?
A. High altitude
B. Elevated hematocrit
C. Elevated rbc mass
D. Tumor in the bone marrow
D. Tumor in the bone marrow
- Production of too many immature cells called blast
C. Myelodysplastic anemia
Which of the following statements about mature circulating erythrocytes is true? *
A.Able to use ketones for ATP production
B. They are packed with mitochondria
C. They have no nucleus
D. They survive for an average of four days
C. They have no nucleus
Which is true about a molecule of hemoglobin? *
A. Can carry up to 120 molecules of oxygen
B. Consist of four globin proteins, each bound to a molecule of heme
C. Contains four glycoprotein units studded with oxygen
D. Shaped like a biconcave disk packed almost entirely with iron
B. Consist of four globin proteins, each bound to a molecule of heme
The production of healthy erythrocytes depends upon the availability of what molecules?
A. Oxygen
B. Vitamin C
C. Zinc
D. Carbon dioxide
C. Zinc
Aging and damaged erythrocytes are removed from the circulation by _________? * A. Myeloblast
B.Macrophages
C. Mast cells
D. Monocytes
B. Macrophage
A patient has been suffering for 2 months with a chronic, watery diarrhea. A blood test would likely to reveal what blood problem? *
A. Hypoxemia
B. Hematocrit below 30%
C. Polycythemia vera
D.Anemia
C. Polycythemia vera
a condition where the bone marrow goes into “overdrive” and makes too many red blood cells, along with too many white blood cells and platelets
A young woman has been experiencing unusually heavy menstrual bleeding for several years. She follows a strict vegan diet (no animal foods). She is at risk for what condition *
A. Anemia
B. Leukopenia
C. Polycythemia vera
D. Thrombocytopenia
A. Anemia
Mario has thalassemia, a genetic disorder characterized by abnormal synthesis of globin proteins and excessive destruction of erythrocytes. What substance might be increased in these cases that can be detected by blood chemistry? *
A. Albumin
B. Bilirubin
C. Iron
D. Hemoglobin
B. Bilirubin
Plasma protein that binds reversibly to iron and distributes it throughout the body. *
Transferrin
Apoferritin
Ferritin
Hemosiderin
Transferrin
How many oxygen molecule can one hemoglobin carry? *
4
Differentiation of a common myeloid progenitor cell to an erythrocyte would require what cytokine and hormone? *
A. interleukin 3, granulocyte macrophage-colony stimulating factor, FT3 ligand and
erythropoietin
B.interleukin 3, interleukin 5, granulocyte macrophage-colony stimulating factor and
erythropoietin
C. interleukin 1, interleukin 3, interleukin 6, granulocyte macrophage-colony stimulating
factor
D. interleukin 3, granulocyte macrophage-colony stimulating factor, stem cell factor
and erythropoietin
D. interleukin 3, granulocyte macrophage-colony stimulating factor, stem cell factor
and erythropoietin
A mature red blood cell is devoid of what organelle? *
A. mitochondria
B. Golgi apparatus
C. Nucleus
D. all of the above
D. all of the above
Glucose enters the red blood cell for ATP production through what transport mechanism? *
facilitated diffusion
primary active transport
simple diffusion
D. secondary active transport
Facilitated diffusion
How does red blood cell generate its energy/ATP? *
Glycolysis
Which enzyme has a physiologic importance in reducing methemoglobin in the body? *
cytochrome b5 reductase
Hereditary spherocytosis and hereditary elliptocytosis is caused by an abnormality of what cytoskeletal protein in the cell membrane of RBCs? *
anion exchange protein
actin
spectrin
Band 3
Spectrin
Which is the plasma protein that binds reversibly to iron and distribute it throughout the body? *
Transferrin
What type of anemia is caused by poor absorption of Vitamin B12 and often seen in patients after removal of the intestines? *
Pernicious anemia
What triggers the release of erythropoietin from the kidneys? *
hypotension.
hypoxia
low iron stores in the body
blood loss
Hypoxia
What are immature red blood cells? *
Reticulocytes
Which is a major integral protein of the RBC membrane? *
Anion exchanged protein
(Band 3)
In ABO blood type system, which blood type has a Gene that encodes for the enzyme galactosamine transferase? *
Type B
The Rho antigen is what type of protein? *
Integral membrane
It is defined as abnormal variation in sizes of RBCs. *
.
anisocytosis
poikilocytosis
polymorphonuclear
aplasia
Anisocytosis
-microcyte
-normocyte
-megalocyte
-macrocyte
Which is an example of RBC with poikilocytosis? *
Stomatocyte
Acantocyte
Target cell
Ovalocyte
Sickle cell
Which of the following leukocyte is an agranulocyte? *
Basophils
Eosinophils
Monocytes
Mast cells
Monocyte
And Lymphocyte
Granulocytes
-neutrophil
-eosinophil
-Basophil
The following are principal steps of an inflammatory response, except: *
A.Vascular constriction to hold invading microorganisms in one place
*increased vascular permeability
B.Spontaneous resolution after invading microorganisms have been exterminated
C. Activation of platelets to release chemokines
D. Activated leukocytes enter the affected tissues
A.Vascular constriction to hold invading microorganisms in one place
-should be increased permeability
PRINCIPAL STEPS IN AN INFLAMMATORY RESPONSE
1) INCREASE IN VASCULAR PERMEABILITY
2) ENTRY OF ACTIVATED LEUKOCYTES INTO THE TISSUE
3) ACTIVATION OF PLATELETS
4) SPONTANEOUS SUBSIDENCE (RESOLUTION) IF THE INVADING MICROORGANISM HAVE BEEN DEALT WITH SUCCESSFULLY