RBC

Question 1

What is the function of Hepcidin (2)

Answer 1

1) Limit iron transfer from Macrophages to Erythroid precursors
2) Suppress EPO production

Question 2

What is the most common congenital defect leading to Sideroblastic anemia?

Answer 2

ALA synthase deficiency (rate limiting step)

Question 3

What are the acquired causes of Sideroblastic Anemia? (3)

Answer 3

1) Lead poisoning (blocks ALAD + Ferrochelatase)
2) Vitamin B 6 deficiency (Isoniazid side effect)
3) Alcohol

Question 4

What is Hemoglobin H and when does it happen?

Answer 4

4 Beta globins

Seen in 3 alpha deletion

Question 5

What is Hemoglobin Barts and when does it happen?

Answer 5

Tetramer of gamma chains

4 alpha deletion

Question 6

What is the inherited pattern of Paroxsymal Nocturna Hemoglobinemia? And what cell is defective?

Answer 6

1) NOT an inherited disease. The disease is ACQUIRED

2) Myeloid Stem Cells lose the ability to express GPi anchoring protein

Question 7

What are some Oxidative stressors associated with G^PD deficiency? (3)

Answer 7

1) Sulfa
2) Anti-malarials
3) Dapsone
4) Fava beans

Question 8

What histological signs will you see on RBCS? (2)

Answer 8

1) Heinz Body

2) Bite Cells

Question 9

What D/O are associated with IgM mediated Immune Hemolytic Anemia? (3)

Answer 9

1) Infectious mononucleosis
2) CLL
3) Mycoplasma pneumoniae

Question 10

What are some associations of IgG mediated Immune Hemolytic Anemia? (Drugs and Two D/O)

Answer 10

1) CLL
2) SLE
3) Cephalosporin
4) Penicillin
5) alpha-methyldopa

Question 11

Cell Surface Marker and Intracellular makrer for B-ALL

Answer 11

CD10 , CD19, CD20, TdT

Question 12

Cell Surface Marker for T-ALL

Answer 12

CD2-8 , TdT

NO CD10