RBC

Question 1

DIC is caused by

Answer 1

excessive activation of COAGULATION

Question 2

2 MC of DIC

Answer 2

1. endothelial injury

2. release of tissue factor or thromboplastins

Question 3

DIC commonly seen in which condition

Answer 3

sepsis
pregnancy complications
trauma
malignant neoplasms

Question 4

which neoplasm are commonly associated with DIC

Answer 4

acute promyelocytic leukemia and adenocarcinoma

Question 5

2 major consequences of DIC

Answer 5

1. fibrin deposition leads to MICROANGIOPATHIC HEMOLYTIC ANEMIA
2. consumption of coag factors and decreased factor V and VIII leads to BLEEDING DIATHESIS

Question 6

deficiency of factor VIII

Answer 6

hemophilia A

Question 7

genetics of hemophilia A

Answer 7

XR- seen in males and homozygous females

Question 8

are petechiae present in hemophilia A

Answer 8

NO

Question 9

PT/PTT in hemophilia A

Answer 9

PT is normal

PTT is prolonged

Question 10

deficiency in factor IX

Answer 10

hemophilia B - aka Christmas disease
same symptoms and lab results as hemophilia A

need to look at assay levels to distinguish between the two

Question 11

MC inherited bleeding disorder

Answer 11

von willebrand disease

Question 12

what is affected in von willebrand disease

Answer 12

*defect in platelet function despite a NORMAL platelet count.

decrease in vWF leads to decrease in factor VIII which can prolong PTT

Question 13

inheritance of von willebrand disease

Answer 13

AD and AR

Question 14

defect in Gp-Ib and vWF

Answer 14

Bernard-Soulier

Question 15

defect in Gp2b/3a and factor 8

Answer 15

glanzmann thrombasthenia

Question 16

defect in TTP

Answer 16

deficiency in enzyme ADAMTS13, which is responsible for breaking down vWF complex.

leads to widespread endothelial injury

Question 17

PTT/PT in DIC

Answer 17

both prolonged

Question 18

PTT/PT in TTP and HUS

Answer 18

both are normal