Rbc Flashcards
Most common hematologic abnormality a/w HIV infection?
Anemia
Which contains most of functional iron in body?
a) hemoglobin
b) myoglobin
c) transferin
d)ferritin
Hemoglobin
Haptocorin and cubulin a/w?
Vit B12 absorption
Mcc of aplastic anemia
Autoimmune
Microcytic anemia failing to respond to iron therapy
Tmprss6 mutation ( norml function is to supress hepcidin production when iron is low)
Tranferin receptor mrna conc amd ferritin mrna conc in iron deficient state
Increase
No change
Mentzer index formula and value in ida
Mcv/rbc count
More than 13
Se. Transferin receptor/log se. Feritin in ida
> 1.5
Corected reticulocyte formula
Given reticulocyte* patient hb / hb of norml age
Mc infectious cause of aplastic anemia
Viral hepatitis
Anemia on metastatic cancer
Myelopthisic anemia
Hbs mutation and Hbc mutation
Point mutation
Hbs glutamic acid replaced by valine
Hbc glutamic acid replaced by lysine
Happene in alpha thalasemia
Gene deletion
Mutation in beta thallesemia
Gene mutation
Most common mutation of beta thallesmia
Splicing mutation
Hb range in thall intermediate and Major
Intermediate - 6 to 9 h/o blood transfusion
Major - <6 no hist
Chipmunk facial appearance seen in
Beta thall major
Hbf vs Hba2 kon se thallesemia m kon sa badta h
Hbf increase in thall major
Hba2 increase in thall minor/trait
HbA to decrease hota hi hai
Osmotic fragility increase in
Hereditary spherocytoIS
Osmotic fragility decrease in
Sickle cell
Thallesmia
Gene for alpha and beta chains
16 and 11
HbH disease m which tetramer
Beta 4
Golf ball apperance
Barts Hb
Gamma 4 tetramer
Baby dies in 3rd trimester
Non immune hydrops fetalis
PNH gene, anchor protein, transmembrane Protein
Piga gene
GpI protein provide anchor to cd59, cd55,c8b
Membrane inhibitor of reactive lysis
CD 59
Thrombosis seen in
Sickle cell anemia
PNH
C3 converstasw inhibitor
Cd59 aka mem inhibitor of reactive lysis
Mcc of death in pnh
Thrombosis budd chiari
C5 inhibitor drug
Eculizumab
Antibody in warm and cold AIHA
IgG igM
Drugs causing aiha
Methyl dopa
Penicillin
Quinidine
Spherocyte most commonly seen in
Aiha
Cause of extravascular hemolysis in cold AIHA
Igm mediated complement activation
C3b attach to rbc which gets destroyed
Cold aglutinin disease
Igm against I antigen of rbc
Cold hemolysin type disease
IgG against p antigen of rbc
Donath landsteiner antibio
IgG against P antigen of rbc
Cold aiha type and respective hemolysis
Hemolysin type me intravascular
Agglutinin type me extravascular
Biphasic erythrocytic antibody
Cold hemolysin IgG aginst P ag of rbc
4 degree p bind
37 degree p complement activation damage
Aplastic anemia a/w or progresses to
Mds
Aml
