Rate Limiting Enzymes

Question 1

rate limiting enzyme of glycolysis

Answer 1

PFK-1

Question 2

rate limiting enzyme of gluconeogenesis

Answer 2

fructose 1,6-bisphosphatase

Question 3

rate limiting enzyme of TCA cycle

Answer 3

isocitrate dehydrogenase

Question 4

rate limiting enzyme of of glycogenesis

Answer 4

glycogen synthase

Question 5

rate limiting enzyme of glycogenolysis

Answer 5

glycogen phosphorylase

Question 6

rate limiting enzyme of HMP shunt (pentose phosphate pathway)

Answer 6

glucose-6-phosphate dehydrogenase (G6PD)

Question 7

rate limiting enzyme of purine synthesis

Answer 7

glutamine phosphoribosylphosphate amidotransferase (PRPP)

Question 8

rate limiting enzyme of pyrimidine synthesis

Answer 8

CPS II

Question 9

rate limiting enzyme of urea cycle

Answer 9

CPS I

Question 10

rate limiting enzyme of fatty acid synthesis

Answer 10

acetyl CoA carboxylase

Question 11

rate limiting enzyme of fatty acid oxidation

Answer 11

carnitine acyltransferase I (CAT I)

Question 12

rate limiting enzyme of ketogenesis

Answer 12

HMG CoA synthase

Question 13

rate limiting enzyme of cholesterol synthesis

Answer 13

HMG CoA reductase

Question 14

what is the rate limiting enzyme of bile synthesis

Answer 14

7-alpha hydroxylase

Question 15

what are 2 activators of PFK-1, the rate limiting enzyme of glycolysis

Answer 15

AMP
fructose 2,6-bisphosphate

Question 16

what are 2 inhibitors of PFK-1, the rate limiting enzyme of glycolysis

Answer 16

ATP
citrate

Question 17

what are 2 activators of fructose 1,6-bisphosphate, the rate limiting enzyme of gluconeogenesis

Answer 17

ATP
citrate

Question 18

what is an activator of the isocitrate dehydrogenase, the rate limiting enzyme of the TCA cycle

Answer 18

ADP

Question 19

what are 2 inhibitors of isocitrate dehydrogenase, the rate limiting enzyme of the TCA cycle

Answer 19

ATP
NADH

Question 20

what are 3 activators of glycogen synthase, the rate limiting enzyme of glycogenesis

Answer 20

glucose 6-phosphate
insulin
cortisol

Question 21

what are 2 inhibitors of glycogen synthase, the rate limiting enzyme of glycogensis

Answer 21

epinephrine
glucagon

Question 22

what are 3 activators of glycogen phosphorylase, the rate limiting enzyme of glycogenolysis

Answer 22

epinephrine
glucagon
AMP

Question 23

what are 3 inhibitors of glycogen phosphorylase, the rate limiting enzyme of glycogenolysis

Answer 23

glucose 6 phosphate
insulin
ATP

Question 24

what activates G6PD, the rate limiting enzyme of the HMP shunt

Answer 24

NADP+

Question 25

what inhibits G6PD, the rate limiting enzyme of the HMP shunt

Answer 25

NADPH

Question 26

what 2 molecules activate CPS II, the rate limiting enzyme of pyrimidine synthesis

Answer 26

ATP
PRPP

Question 27

what inhibits CPS II, the rate limiting enzyme of pyrimidine synthesis

Answer 27

UTP

Question 28

what 3 molecules inhibit PRPP, the rate limiting enzyme of purine synthesis

Answer 28

GXP
AXP
IMP

Question 29

what activates CPS I, the rate limiting enzyme of the urea cycle

Answer 29

NAG

Question 30

what 2 molecules activate acetyl CoA carboxylase, the rate limiting enzyme of FA synthesis

Answer 30

insulin
citrate

Question 31

what molecule inhibit acetyl CoA carboxylase, the rate limiting enzyme of FA synthesis

Answer 31

glucagon

Question 32

what molecule inhibits CAT I, the rate limiting enzyme of fatty acid oxidation

Answer 32

malonyl CoA