Rapid Tranquillisation & Mood Stabilisers Flashcards

1
Q

What is the first step in treating someone acutely psychotic?

A
  • Always talk to patient and de-escalate first line

- Try non-drug techniques first, assess the level of risk - is sedation necessary?

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2
Q

What medications can be used in rapid tranquillisation?

A

1) Lorazepam
2) Haloperidol ± promethazine
3) Olanzapine (also risperidone, aripiprazole)

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3
Q

How would you give medication for rapid tranquillisation first line?

A

Oral (if pt is willing)

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4
Q

Why is IM last resort?

A

The patient would need to be restrained

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5
Q

What would you do next if that patient won’t calm down from talking?

A

Try and convince them to take medication orally

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6
Q

When should you use lorazepam for rapid tranquillisation (avoid antipsychotics)?

A

1) Dementia & delirium
2) Parkinson’s
3) Lewy body dementia

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7
Q

When would you use antipsychotic for rapid tranquillisation (haloperidol)?

A

1) If pt already takes an antipsychotic they might respond better to haloperidol
2) If don’t want to cause respiratory depression (low RR?)

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8
Q

What medications should you have on hand when doing rapid tranquillisation?

A

Flumazenil and procyclidine

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9
Q

Why should you not give antipsychotics to patients with Parkinson’s or LBD?

A

Bc they are dopamine blockers

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10
Q

What should you do for patients if giving them rapid tranquillisation?

A
  • Check their obs
  • Do ECG if giving antipsychotic
  • Monitor for side effects
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11
Q

When should you not use medication for rapid tranquillisation?

A

Delirium

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12
Q

When would you use IM medication dose of medication for rapid tranquillisation?

A

After an hour of waiting for oral dose to work and continuing non-drug approaches - use the same drug

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13
Q

What drugs can be used as mood stabilisers?

A

1) Lithium

2) Anticonvulsants

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14
Q

What are examples of anticonvulsants that can be used as mood stabilisers?

A
  • Carbamazepine
  • Sodium valproate
  • Lamotrigine
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15
Q

What can mood stabilisers be used to treat?

A
  • Bipolar disorder lithium long term
  • Treatment resistant depression/anxiety
  • Personality disorders
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16
Q

Why does lithium cause cardiac, renal and thyroid problems?

A

Lithium deposits can cause cardiomyopathy, thyroid problems, or decline in renal function (stuck in glomerular apparatus)

17
Q

What do you need to do if eGFR is really low on lithium?

A

Have to come off it otherwise need renal replacement

18
Q

Why does lithium need close monitoring?

A

It has a narrow therapeutic window

19
Q

How do you monitor lithium levels?

A

Need regular serum levels (aim 0.4-1.0 mmol/L)

  • Start with weekly serum lithium levels
  • Then 3 monthly when stable
  • Then 6 monthly
20
Q

What should you measure before starting lithium?

A

Baseline cardiac, renal and thyroid function

21
Q

What should you measure every 6 months other than lithium levels when taking lithium?

A
  • BMI
  • eGFR
  • TFTs
  • U&Es
22
Q

What level is lithium toxicity?

A

Serum lithium 2.0-3.0

23
Q

What are the signs and symptoms of lithium toxicity?

A
  • Drowsiness
  • Confusion
  • Ataxia
  • Coarse tremor
  • Muscle weakness
  • Seizures
24
Q

What are adverse effects of lithium?

A
  • N&V
  • Anorexia
  • Diarrhoea
  • Fine tremor
  • Dry mouth
  • Polydipsia & polyuria
  • Hypothyroidism
  • Weight gain
25
Q

What would you do if someone has bad renal function but needs a mood stabiliser?

A

Try and avoid lithium or start on a bit of lithium and then go to anticonvulsants

26
Q

What medication should you never give to a woman of child bearing age?

A

Sodium valproate

27
Q

What are side effects of anti-convulsants?

A
  • Drowsiness
  • Fatigue
  • Agitation
  • Headaches
  • Tremor
  • Hair loss or unwanted hair growth
  • Swollen gums
  • Rashes
  • Weight gain
  • Nausea
28
Q

How do you start someone on lithium?

A

Up-titration

29
Q

What antipsychotic is often used in BPD?

A

Aripiprazole